COVID-19 studies are our top priority.

For new and updated trial submissions, we are processing trials as quickly as possible and appreciate your patience. We recommend submitting your trial for registration at the same time as ethics submission.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/show/NCT02545049




Registration number
NCT02545049
Ethics application status
Date submitted
2/09/2015
Date registered
9/09/2015
Date last updated
8/04/2021

Titles & IDs
Public title
Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease
Scientific title
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Event-driven Phase 3 Study to Investigate Efficacy and Safety of Finerenone on the Reduction of Cardiovascular Morbidity and Mortality in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease in Addition to Standard of Care.
Secondary ID [1] 0 0
2015-000950-39
Secondary ID [2] 0 0
17530
Universal Trial Number (UTN)
Trial acronym
FIGARO-DKD
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Diabetic Kidney Disease 0 0
Condition category
Condition code
Renal and Urogenital 0 0 0 0
Kidney disease
Metabolic and Endocrine 0 0 0 0
Diabetes

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Finerenone (BAY94-8862)
Treatment: Drugs - Placebo

Experimental: BAY94-8862 - Finerenone tablet

Placebo Comparator: Placebo - Matching placebo


Treatment: Drugs: Finerenone (BAY94-8862)
10 mg or 20 mg Finerenone tablet to be given orally, once daily.

Treatment: Drugs: Placebo
Matching placebo to be taken orally, once daily.

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Time to the first occurrence of the composite endpoint of cardiovascular death and non-fatal cardiovascular events (myocardial infarction, stroke, or hospitalization for heart failure)
Timepoint [1] 0 0
Time to total follow up (Up to 53 months)
Secondary outcome [1] 0 0
Time to first occurrence of the following composite endpoints: onset of kidney failure, a sustained decrease in estimated glomerular filtration rate (eGFR)of =40% from baseline over at least 4 weeks and renal death
Timepoint [1] 0 0
Time to total Follow up (Up to 53 months)
Secondary outcome [2] 0 0
Time to all-cause mortality
Timepoint [2] 0 0
Time to total Follow up (Up to 53 months)
Secondary outcome [3] 0 0
Time to all-cause hospitalization
Timepoint [3] 0 0
Time to total Follow up (Up to 53 months)
Secondary outcome [4] 0 0
Change in urinary albumin-to-creatine ratio (UCAR) from baseline to month 4
Timepoint [4] 0 0
Baseline to Month 4
Secondary outcome [5] 0 0
Time to first occurrence of the following composite endpoint: onset of kidney failure, a sustained decrease in estimated glomerular filtration rate (eGFR) of = 57% from baseline over at least 4 weeks or renal death.
Timepoint [5] 0 0
Time to total Follow up (Up to 53 months)

Eligibility
Key inclusion criteria
- Men or women =18 years of age

- Subjects with Type Type 2 Diabetes Mellitus as defined by the American Diabetes
Association

- Diagnosis of Diabetic Kidney Disease with persistent high albuminuria or persistent
very high albuminuria at the Run-In and Screening Visit

- Pretreated with either angiotensin-converting enzyme inhibitor (ACEI) or angiotensin
receptor blocker (ARB) at maximal tolerated labeled dose without adjustments

- Serum potassium <=4.8 mmol/L
Minimum age
18 Years
Maximum age
No limit
Gender
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
- Confirmed significant non-diabetic renal disease, including clinically relevant renal
artery stenosis

- Uncontrolled arterial hypertension (ie, mean sitting systolic blood pressure (SBP)
=170 mmHg or mean sitting diastolic blood pressure(DBP) =110 mmHg at run in visit, or
mean sitting SBP =160 mmHg or mean sitting DBP =100 mmHg at screening)

- Clinical diagnosis of chronic heart failure with reduced ejection fraction (HFrEF) and
persistent symptoms {New York Heart Association (NYHA) class II - IV} at Run in visit
[class 1A recommendation for mineralcorticoid receptor antagonist (MRAs)]

- Dialysis for acute renal failure within 12 weeks of Run-in visit

- Renal allograft in place or scheduled kidney transplant within next 12 months

- Glycated hemoglobin (HbA1c) >12%

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,VIC
Recruitment hospital [1] 0 0
- Garran
Recruitment hospital [2] 0 0
- Gosford
Recruitment hospital [3] 0 0
- Kanwal
Recruitment hospital [4] 0 0
- Liverpool
Recruitment hospital [5] 0 0
- New Lambton Heights
Recruitment hospital [6] 0 0
- Wollongong
Recruitment hospital [7] 0 0
- Brisbane
Recruitment hospital [8] 0 0
- Adelaide
Recruitment hospital [9] 0 0
- Fitzroy
Recruitment hospital [10] 0 0
- Heidelberg
Recruitment hospital [11] 0 0
- Melbourne
Recruitment hospital [12] 0 0
- Prahran
Recruitment hospital [13] 0 0
- Reservoir
Recruitment hospital [14] 0 0
- Richmond
Recruitment hospital [15] 0 0
- St. Albans
Recruitment hospital [16] 0 0
- Elizabeth Vale
Recruitment postcode(s) [1] 0 0
2605 - Garran
Recruitment postcode(s) [2] 0 0
2250 - Gosford
Recruitment postcode(s) [3] 0 0
2259 - Kanwal
Recruitment postcode(s) [4] 0 0
2170 - Liverpool
Recruitment postcode(s) [5] 0 0
2305 - New Lambton Heights
Recruitment postcode(s) [6] 0 0
2500 - Wollongong
Recruitment postcode(s) [7] 0 0
4064 - Brisbane
Recruitment postcode(s) [8] 0 0
5000 - Adelaide
Recruitment postcode(s) [9] 0 0
3065 - Fitzroy
Recruitment postcode(s) [10] 0 0
3081 - Heidelberg
Recruitment postcode(s) [11] 0 0
3052 - Melbourne
Recruitment postcode(s) [12] 0 0
3181 - Prahran
Recruitment postcode(s) [13] 0 0
3073 - Reservoir
Recruitment postcode(s) [14] 0 0
3121 - Richmond
Recruitment postcode(s) [15] 0 0
3021 - St. Albans
Recruitment postcode(s) [16] 0 0
5112 - Elizabeth Vale
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
California
Country [4] 0 0
United States of America
State/province [4] 0 0
Connecticut
Country [5] 0 0
United States of America
State/province [5] 0 0
Florida
Country [6] 0 0
United States of America
State/province [6] 0 0
Georgia
Country [7] 0 0
United States of America
State/province [7] 0 0
Hawaii
Country [8] 0 0
United States of America
State/province [8] 0 0
Illinois
Country [9] 0 0
United States of America
State/province [9] 0 0
Indiana
Country [10] 0 0
United States of America
State/province [10] 0 0
Iowa
Country [11] 0 0
United States of America
State/province [11] 0 0
Kansas
Country [12] 0 0
United States of America
State/province [12] 0 0
Louisiana
Country [13] 0 0
United States of America
State/province [13] 0 0
Massachusetts
Country [14] 0 0
United States of America
State/province [14] 0 0
Michigan
Country [15] 0 0
United States of America
State/province [15] 0 0
Minnesota
Country [16] 0 0
United States of America
State/province [16] 0 0
Missouri
Country [17] 0 0
United States of America
State/province [17] 0 0
Nebraska
Country [18] 0 0
United States of America
State/province [18] 0 0
Nevada
Country [19] 0 0
United States of America
State/province [19] 0 0
New Jersey
Country [20] 0 0
United States of America
State/province [20] 0 0
New Mexico
Country [21] 0 0
United States of America
State/province [21] 0 0
New York
Country [22] 0 0
United States of America
State/province [22] 0 0
North Carolina
Country [23] 0 0
United States of America
State/province [23] 0 0
Ohio
Country [24] 0 0
United States of America
State/province [24] 0 0
Pennsylvania
Country [25] 0 0
United States of America
State/province [25] 0 0
South Carolina
Country [26] 0 0
United States of America
State/province [26] 0 0
Tennessee
Country [27] 0 0
United States of America
State/province [27] 0 0
Texas
Country [28] 0 0
United States of America
State/province [28] 0 0
Utah
Country [29] 0 0
United States of America
State/province [29] 0 0
Vermont
Country [30] 0 0
United States of America
State/province [30] 0 0
Virginia
Country [31] 0 0
United States of America
State/province [31] 0 0
Washington
Country [32] 0 0
Argentina
State/province [32] 0 0
Buenos Aires
Country [33] 0 0
Argentina
State/province [33] 0 0
Ciudad Auton. De Buenos Aires
Country [34] 0 0
Argentina
State/province [34] 0 0
Córdoba
Country [35] 0 0
Argentina
State/province [35] 0 0
San Luis
Country [36] 0 0
Austria
State/province [36] 0 0
Oberösterreich
Country [37] 0 0
Austria
State/province [37] 0 0
Steiermark
Country [38] 0 0
Austria
State/province [38] 0 0
Tirol
Country [39] 0 0
Austria
State/province [39] 0 0
Vorarlberg
Country [40] 0 0
Austria
State/province [40] 0 0
Innsbruck
Country [41] 0 0
Austria
State/province [41] 0 0
Salzburg
Country [42] 0 0
Austria
State/province [42] 0 0
Wels
Country [43] 0 0
Austria
State/province [43] 0 0
Wien
Country [44] 0 0
Belgium
State/province [44] 0 0
Bruxelles - Brussel
Country [45] 0 0
Belgium
State/province [45] 0 0
Edegem
Country [46] 0 0
Belgium
State/province [46] 0 0
Gent
Country [47] 0 0
Belgium
State/province [47] 0 0
Ieper
Country [48] 0 0
Belgium
State/province [48] 0 0
Kortrijk
Country [49] 0 0
Belgium
State/province [49] 0 0
Leuven
Country [50] 0 0
Belgium
State/province [50] 0 0
Liege
Country [51] 0 0
Belgium
State/province [51] 0 0
Roeselare
Country [52] 0 0
Brazil
State/province [52] 0 0
Ceará
Country [53] 0 0
Brazil
State/province [53] 0 0
Distrito Federal
Country [54] 0 0
Brazil
State/province [54] 0 0
Goiás
Country [55] 0 0
Brazil
State/province [55] 0 0
Minas Gerais
Country [56] 0 0
Brazil
State/province [56] 0 0
Parana
Country [57] 0 0
Brazil
State/province [57] 0 0
Rio Grande Do Sul
Country [58] 0 0
Brazil
State/province [58] 0 0
Sao Paulo
Country [59] 0 0
Brazil
State/province [59] 0 0
Rio de Janeiro
Country [60] 0 0
Bulgaria
State/province [60] 0 0
Blagoevgrad
Country [61] 0 0
Bulgaria
State/province [61] 0 0
Botevgrad
Country [62] 0 0
Bulgaria
State/province [62] 0 0
Dimitrovgrad
Country [63] 0 0
Bulgaria
State/province [63] 0 0
Gorna Oryahovitsa
Country [64] 0 0
Bulgaria
State/province [64] 0 0
Kazanlak
Country [65] 0 0
Bulgaria
State/province [65] 0 0
Kozloduy
Country [66] 0 0
Bulgaria
State/province [66] 0 0
Lukovit
Country [67] 0 0
Bulgaria
State/province [67] 0 0
Plovdiv
Country [68] 0 0
Bulgaria
State/province [68] 0 0
Razgrad
Country [69] 0 0
Bulgaria
State/province [69] 0 0
Sliven
Country [70] 0 0
Bulgaria
State/province [70] 0 0
Sofia
Country [71] 0 0
Bulgaria
State/province [71] 0 0
Stara Zagora
Country [72] 0 0
Bulgaria
State/province [72] 0 0
Varna
Country [73] 0 0
Bulgaria
State/province [73] 0 0
Yambol
Country [74] 0 0
Canada
State/province [74] 0 0
Alberta
Country [75] 0 0
Canada
State/province [75] 0 0
British Columbia
Country [76] 0 0
Canada
State/province [76] 0 0
Newfoundland and Labrador
Country [77] 0 0
Canada
State/province [77] 0 0
Nova Scotia
Country [78] 0 0
Canada
State/province [78] 0 0
Ontario
Country [79] 0 0
Canada
State/province [79] 0 0
Quebec
Country [80] 0 0
Chile
State/province [80] 0 0
Los Lagos
Country [81] 0 0
Chile
State/province [81] 0 0
Santiago
Country [82] 0 0
China
State/province [82] 0 0
Fujian
Country [83] 0 0
China
State/province [83] 0 0
Gansu
Country [84] 0 0
China
State/province [84] 0 0
Guangdong
Country [85] 0 0
China
State/province [85] 0 0
Guangxi
Country [86] 0 0
China
State/province [86] 0 0
Hainan
Country [87] 0 0
China
State/province [87] 0 0
Hubei
Country [88] 0 0
China
State/province [88] 0 0
Hunan
Country [89] 0 0
China
State/province [89] 0 0
Inner Mongolia
Country [90] 0 0
China
State/province [90] 0 0
Jiangsu
Country [91] 0 0
China
State/province [91] 0 0
Jiangxi
Country [92] 0 0
China
State/province [92] 0 0
Jilin
Country [93] 0 0
China
State/province [93] 0 0
Liaoning
Country [94] 0 0
China
State/province [94] 0 0
Ningxia
Country [95] 0 0
China
State/province [95] 0 0
Shaanxi
Country [96] 0 0
China
State/province [96] 0 0
Shandong
Country [97] 0 0
China
State/province [97] 0 0
Shanxi
Country [98] 0 0
China
State/province [98] 0 0
Sichuan
Country [99] 0 0
China
State/province [99] 0 0
Xinjiang
Country [100] 0 0
China
State/province [100] 0 0
Zhejiang
Country [101] 0 0
China
State/province [101] 0 0
Beijing
Country [102] 0 0
China
State/province [102] 0 0
Chongqing
Country [103] 0 0
China
State/province [103] 0 0
Shanghai
Country [104] 0 0
China
State/province [104] 0 0
Tianjin
Country [105] 0 0
Colombia
State/province [105] 0 0
Antioquia
Country [106] 0 0
Colombia
State/province [106] 0 0
Atlántico
Country [107] 0 0
Colombia
State/province [107] 0 0
Caldas
Country [108] 0 0
Colombia
State/province [108] 0 0
Cundinamarca
Country [109] 0 0
Colombia
State/province [109] 0 0
Distrito Capital De Bogotá
Country [110] 0 0
Colombia
State/province [110] 0 0
Nariño
Country [111] 0 0
Colombia
State/province [111] 0 0
Quindío
Country [112] 0 0
Colombia
State/province [112] 0 0
Risaralda
Country [113] 0 0
Colombia
State/province [113] 0 0
Valle Del Cauca
Country [114] 0 0
Colombia
State/province [114] 0 0
Barranquilla
Country [115] 0 0
Colombia
State/province [115] 0 0
Bogota
Country [116] 0 0
Colombia
State/province [116] 0 0
Floridablanca
Country [117] 0 0
Colombia
State/province [117] 0 0
Medellín
Country [118] 0 0
Czechia
State/province [118] 0 0
Beroun
Country [119] 0 0
Czechia
State/province [119] 0 0
Brandys nad Labem
Country [120] 0 0
Czechia
State/province [120] 0 0
Breclav
Country [121] 0 0
Czechia
State/province [121] 0 0
Ceska Lipa
Country [122] 0 0
Czechia
State/province [122] 0 0
Cesky Krumlov
Country [123] 0 0
Czechia
State/province [123] 0 0
Frydek-Mistek
Country [124] 0 0
Czechia
State/province [124] 0 0
Hodonin
Country [125] 0 0
Czechia
State/province [125] 0 0
Holesov
Country [126] 0 0
Czechia
State/province [126] 0 0
Hranice
Country [127] 0 0
Czechia
State/province [127] 0 0
Koprivnice
Country [128] 0 0
Czechia
State/province [128] 0 0
Krnov
Country [129] 0 0
Czechia
State/province [129] 0 0
Mlada Boleslav
Country [130] 0 0
Czechia
State/province [130] 0 0
Olomouc
Country [131] 0 0
Czechia
State/province [131] 0 0
Ostrava
Country [132] 0 0
Czechia
State/province [132] 0 0
Plzen
Country [133] 0 0
Czechia
State/province [133] 0 0
Prague 6
Country [134] 0 0
Czechia
State/province [134] 0 0
Praha 2
Country [135] 0 0
Czechia
State/province [135] 0 0
Praha 4
Country [136] 0 0
Czechia
State/province [136] 0 0
Praha 5
Country [137] 0 0
Czechia
State/province [137] 0 0
Vlasim
Country [138] 0 0
Denmark
State/province [138] 0 0
Aalborg
Country [139] 0 0
Denmark
State/province [139] 0 0
Aarhus N
Country [140] 0 0
Denmark
State/province [140] 0 0
Esbjerg
Country [141] 0 0
Denmark
State/province [141] 0 0
Gentofte
Country [142] 0 0
Denmark
State/province [142] 0 0
Hellerup
Country [143] 0 0
Denmark
State/province [143] 0 0
Herlev
Country [144] 0 0
Denmark
State/province [144] 0 0
Hillerød
Country [145] 0 0
Denmark
State/province [145] 0 0
Holbæk
Country [146] 0 0
Denmark
State/province [146] 0 0
Holstebro
Country [147] 0 0
Denmark
State/province [147] 0 0
Hvidovre
Country [148] 0 0
Denmark
State/province [148] 0 0
Kolding
Country [149] 0 0
Denmark
State/province [149] 0 0
København NV
Country [150] 0 0
Denmark
State/province [150] 0 0
Odense C
Country [151] 0 0
Denmark
State/province [151] 0 0
Svendborg
Country [152] 0 0
Denmark
State/province [152] 0 0
Viborg
Country [153] 0 0
Finland
State/province [153] 0 0
Jyväskylä
Country [154] 0 0
Finland
State/province [154] 0 0
Kajaani
Country [155] 0 0
Finland
State/province [155] 0 0
Kerava
Country [156] 0 0
Finland
State/province [156] 0 0
Klaukkala
Country [157] 0 0
Finland
State/province [157] 0 0
Kuopio
Country [158] 0 0
Finland
State/province [158] 0 0
Nurmijärvi
Country [159] 0 0
Finland
State/province [159] 0 0
Oulu
Country [160] 0 0
Finland
State/province [160] 0 0
Rauma
Country [161] 0 0
Finland
State/province [161] 0 0
Seinäjoki
Country [162] 0 0
Finland
State/province [162] 0 0
Tampere
Country [163] 0 0
Finland
State/province [163] 0 0
Turku
Country [164] 0 0
Finland
State/province [164] 0 0
Vantaa
Country [165] 0 0
France
State/province [165] 0 0
Bois-guillaume
Country [166] 0 0
France
State/province [166] 0 0
Boulogne Sur Mer
Country [167] 0 0
France
State/province [167] 0 0
Brest
Country [168] 0 0
France
State/province [168] 0 0
COLMAR Cedex
Country [169] 0 0
France
State/province [169] 0 0
Dijon
Country [170] 0 0
France
State/province [170] 0 0
Grenoble Cedex 9
Country [171] 0 0
France
State/province [171] 0 0
Le Coudray
Country [172] 0 0
France
State/province [172] 0 0
Le Creusot
Country [173] 0 0
France
State/province [173] 0 0
Lyon Cedex
Country [174] 0 0
France
State/province [174] 0 0
Mulhouse
Country [175] 0 0
France
State/province [175] 0 0
NIMES cedex 9
Country [176] 0 0
France
State/province [176] 0 0
Paris
Country [177] 0 0
France
State/province [177] 0 0
Saint Herblain
Country [178] 0 0
France
State/province [178] 0 0
Tourcoing
Country [179] 0 0
France
State/province [179] 0 0
Vandoeuvre-les-nancy
Country [180] 0 0
France
State/province [180] 0 0
Venissieux
Country [181] 0 0
Germany
State/province [181] 0 0
Baden-Württemberg
Country [182] 0 0
Germany
State/province [182] 0 0
Bayern
Country [183] 0 0
Germany
State/province [183] 0 0
Brandenburg
Country [184] 0 0
Germany
State/province [184] 0 0
Hessen
Country [185] 0 0
Germany
State/province [185] 0 0
Niedersachsen
Country [186] 0 0
Germany
State/province [186] 0 0
Nordrhein-Westfalen
Country [187] 0 0
Germany
State/province [187] 0 0
Rheinland-Pfalz
Country [188] 0 0
Germany
State/province [188] 0 0
Sachsen-Anhalt
Country [189] 0 0
Germany
State/province [189] 0 0
Sachsen
Country [190] 0 0
Germany
State/province [190] 0 0
Thüringen
Country [191] 0 0
Germany
State/province [191] 0 0
Berlin
Country [192] 0 0
Germany
State/province [192] 0 0
Hamburg
Country [193] 0 0
Greece
State/province [193] 0 0
Alexandroupolis
Country [194] 0 0
Greece
State/province [194] 0 0
Athens
Country [195] 0 0
Greece
State/province [195] 0 0
Chaidari
Country [196] 0 0
Greece
State/province [196] 0 0
Larissa
Country [197] 0 0
Greece
State/province [197] 0 0
Nea Ionia
Country [198] 0 0
Greece
State/province [198] 0 0
Thessaloniki
Country [199] 0 0
Hong Kong
State/province [199] 0 0
Hong Kong
Country [200] 0 0
Hong Kong
State/province [200] 0 0
Shatin
Country [201] 0 0
Hong Kong
State/province [201] 0 0
Sheung Wan
Country [202] 0 0
Hong Kong
State/province [202] 0 0
Wong Tai Sin
Country [203] 0 0
Hungary
State/province [203] 0 0
Baja
Country [204] 0 0
Hungary
State/province [204] 0 0
Balatonfured
Country [205] 0 0
Hungary
State/province [205] 0 0
Budapest
Country [206] 0 0
Hungary
State/province [206] 0 0
Debrecen
Country [207] 0 0
Hungary
State/province [207] 0 0
Eger
Country [208] 0 0
Hungary
State/province [208] 0 0
Kistarcsa
Country [209] 0 0
Hungary
State/province [209] 0 0
Nyiregyhaza
Country [210] 0 0
Hungary
State/province [210] 0 0
Papa
Country [211] 0 0
Hungary
State/province [211] 0 0
Siofok
Country [212] 0 0
Hungary
State/province [212] 0 0
Szeged
Country [213] 0 0
Hungary
State/province [213] 0 0
Szekesfehervar
Country [214] 0 0
Hungary
State/province [214] 0 0
Szentes
Country [215] 0 0
Hungary
State/province [215] 0 0
Szombathely
Country [216] 0 0
Ireland
State/province [216] 0 0
Cork
Country [217] 0 0
Ireland
State/province [217] 0 0
Dublin
Country [218] 0 0
Ireland
State/province [218] 0 0
Galway
Country [219] 0 0
Israel
State/province [219] 0 0
Afula
Country [220] 0 0
Israel
State/province [220] 0 0
Ashkelon
Country [221] 0 0
Israel
State/province [221] 0 0
Beer Sheva
Country [222] 0 0
Israel
State/province [222] 0 0
Haifa
Country [223] 0 0
Israel
State/province [223] 0 0
Holon
Country [224] 0 0
Israel
State/province [224] 0 0
Jerusalem
Country [225] 0 0
Israel
State/province [225] 0 0
Kfar Saba
Country [226] 0 0
Israel
State/province [226] 0 0
Nahariya
Country [227] 0 0
Israel
State/province [227] 0 0
Nazareth
Country [228] 0 0
Israel
State/province [228] 0 0
Ramat Gan
Country [229] 0 0
Israel
State/province [229] 0 0
Rehovot
Country [230] 0 0
Israel
State/province [230] 0 0
Sakhnin
Country [231] 0 0
Israel
State/province [231] 0 0
Tel Aviv
Country [232] 0 0
Israel
State/province [232] 0 0
Tiberias
Country [233] 0 0
Israel
State/province [233] 0 0
Zefat
Country [234] 0 0
Israel
State/province [234] 0 0
Zerifin
Country [235] 0 0
Italy
State/province [235] 0 0
Campania
Country [236] 0 0
Italy
State/province [236] 0 0
Emilia-Romagna
Country [237] 0 0
Italy
State/province [237] 0 0
Liguria
Country [238] 0 0
Italy
State/province [238] 0 0
Lombardia
Country [239] 0 0
Italy
State/province [239] 0 0
Piemonte
Country [240] 0 0
Italy
State/province [240] 0 0
Sardegna
Country [241] 0 0
Italy
State/province [241] 0 0
Sicilia
Country [242] 0 0
Italy
State/province [242] 0 0
Toscana
Country [243] 0 0
Italy
State/province [243] 0 0
Veneto
Country [244] 0 0
Japan
State/province [244] 0 0
Aichi
Country [245] 0 0
Japan
State/province [245] 0 0
Chiba
Country [246] 0 0
Japan
State/province [246] 0 0
Ehime
Country [247] 0 0
Japan
State/province [247] 0 0
Fukuoka
Country [248] 0 0
Japan
State/province [248] 0 0
Fukushima
Country [249] 0 0
Japan
State/province [249] 0 0
Gifu
Country [250] 0 0
Japan
State/province [250] 0 0
Gunma
Country [251] 0 0
Japan
State/province [251] 0 0
Hiroshima
Country [252] 0 0
Japan
State/province [252] 0 0
Hokkaido
Country [253] 0 0
Japan
State/province [253] 0 0
Hyogo
Country [254] 0 0
Japan
State/province [254] 0 0
Ibaraki
Country [255] 0 0
Japan
State/province [255] 0 0
Ishikawa
Country [256] 0 0
Japan
State/province [256] 0 0
Kagawa
Country [257] 0 0
Japan
State/province [257] 0 0
Kanagawa
Country [258] 0 0
Japan
State/province [258] 0 0
Kumamoto
Country [259] 0 0
Japan
State/province [259] 0 0
Nagasaki
Country [260] 0 0
Japan
State/province [260] 0 0
Oita
Country [261] 0 0
Japan
State/province [261] 0 0
Okinawa
Country [262] 0 0
Japan
State/province [262] 0 0
Osaka
Country [263] 0 0
Japan
State/province [263] 0 0
Saitama
Country [264] 0 0
Japan
State/province [264] 0 0
Shiga
Country [265] 0 0
Japan
State/province [265] 0 0
Shizuoka
Country [266] 0 0
Japan
State/province [266] 0 0
Tochigi
Country [267] 0 0
Japan
State/province [267] 0 0
Tokyo
Country [268] 0 0
Japan
State/province [268] 0 0
Fukui
Country [269] 0 0
Japan
State/province [269] 0 0
Kagoshima
Country [270] 0 0
Korea, Republic of
State/province [270] 0 0
Gang''weondo
Country [271] 0 0
Korea, Republic of
State/province [271] 0 0
Gyeonggido
Country [272] 0 0
Korea, Republic of
State/province [272] 0 0
Busan
Country [273] 0 0
Korea, Republic of
State/province [273] 0 0
Daegu
Country [274] 0 0
Korea, Republic of
State/province [274] 0 0
Seoul
Country [275] 0 0
Lithuania
State/province [275] 0 0
Kaunas
Country [276] 0 0
Lithuania
State/province [276] 0 0
Klaipeda
Country [277] 0 0
Lithuania
State/province [277] 0 0
Utena
Country [278] 0 0
Lithuania
State/province [278] 0 0
Vilnius
Country [279] 0 0
Malaysia
State/province [279] 0 0
Johor Bahru
Country [280] 0 0
Malaysia
State/province [280] 0 0
Kelantan
Country [281] 0 0
Malaysia
State/province [281] 0 0
Kuala Lumpur
Country [282] 0 0
Malaysia
State/province [282] 0 0
Pahang
Country [283] 0 0
Malaysia
State/province [283] 0 0
Perak
Country [284] 0 0
Malaysia
State/province [284] 0 0
Pulau Pinang
Country [285] 0 0
Malaysia
State/province [285] 0 0
Putrajaya
Country [286] 0 0
Malaysia
State/province [286] 0 0
Selangor
Country [287] 0 0
Mexico
State/province [287] 0 0
Distrito Federal
Country [288] 0 0
Mexico
State/province [288] 0 0
Jalisco
Country [289] 0 0
Mexico
State/province [289] 0 0
Morelos
Country [290] 0 0
Mexico
State/province [290] 0 0
Nuevo Leon
Country [291] 0 0
Mexico
State/province [291] 0 0
Querétaro
Country [292] 0 0
Mexico
State/province [292] 0 0
Sinaloa
Country [293] 0 0
Mexico
State/province [293] 0 0
Veracruz
Country [294] 0 0
Mexico
State/province [294] 0 0
Aguascalientes
Country [295] 0 0
Mexico
State/province [295] 0 0
Chihuahua
Country [296] 0 0
Mexico
State/province [296] 0 0
Durango
Country [297] 0 0
Netherlands
State/province [297] 0 0
Alkmaar
Country [298] 0 0
Netherlands
State/province [298] 0 0
Almere
Country [299] 0 0
Netherlands
State/province [299] 0 0
Amersfoort
Country [300] 0 0
Netherlands
State/province [300] 0 0
Amsterdam
Country [301] 0 0
Netherlands
State/province [301] 0 0
Apeldoorn
Country [302] 0 0
Netherlands
State/province [302] 0 0
Breda
Country [303] 0 0
Netherlands
State/province [303] 0 0
Den Haag
Country [304] 0 0
Netherlands
State/province [304] 0 0
Eindhoven
Country [305] 0 0
Netherlands
State/province [305] 0 0
Groningen
Country [306] 0 0
Netherlands
State/province [306] 0 0
Hoogeveen
Country [307] 0 0
Netherlands
State/province [307] 0 0
Sittard-geleen
Country [308] 0 0
Netherlands
State/province [308] 0 0
Zwijndrecht
Country [309] 0 0
New Zealand
State/province [309] 0 0
Auckland
Country [310] 0 0
New Zealand
State/province [310] 0 0
Christchurch
Country [311] 0 0
New Zealand
State/province [311] 0 0
Hamilton
Country [312] 0 0
New Zealand
State/province [312] 0 0
Hawkes Bay
Country [313] 0 0
New Zealand
State/province [313] 0 0
Palmerston North
Country [314] 0 0
New Zealand
State/province [314] 0 0
Tauranga
Country [315] 0 0
New Zealand
State/province [315] 0 0
Wellington
Country [316] 0 0
Norway
State/province [316] 0 0
Hamar
Country [317] 0 0
Norway
State/province [317] 0 0
Kløfta
Country [318] 0 0
Norway
State/province [318] 0 0
Kongsvinger
Country [319] 0 0
Norway
State/province [319] 0 0
Kristiansand
Country [320] 0 0
Norway
State/province [320] 0 0
Levanger
Country [321] 0 0
Norway
State/province [321] 0 0
Lierskogen
Country [322] 0 0
Norway
State/province [322] 0 0
Oslo
Country [323] 0 0
Norway
State/province [323] 0 0
Skedsmokorset
Country [324] 0 0
Norway
State/province [324] 0 0
Ålesund
Country [325] 0 0
Philippines
State/province [325] 0 0
Iloilo City
Country [326] 0 0
Philippines
State/province [326] 0 0
Marikina City
Country [327] 0 0
Philippines
State/province [327] 0 0
Pasig City
Country [328] 0 0
Philippines
State/province [328] 0 0
Quezon City
Country [329] 0 0
Poland
State/province [329] 0 0
Bialystok
Country [330] 0 0
Poland
State/province [330] 0 0
Bydgoszcz
Country [331] 0 0
Poland
State/province [331] 0 0
Chojnice
Country [332] 0 0
Poland
State/province [332] 0 0
Gdansk
Country [333] 0 0
Poland
State/province [333] 0 0
Gdynia
Country [334] 0 0
Poland
State/province [334] 0 0
Katowice
Country [335] 0 0
Poland
State/province [335] 0 0
Krakow
Country [336] 0 0
Poland
State/province [336] 0 0
Lodz
Country [337] 0 0
Poland
State/province [337] 0 0
Lublin
Country [338] 0 0
Poland
State/province [338] 0 0
Poznan
Country [339] 0 0
Poland
State/province [339] 0 0
Rzeszow
Country [340] 0 0
Poland
State/province [340] 0 0
Skorzewo
Country [341] 0 0
Poland
State/province [341] 0 0
Szczecin
Country [342] 0 0
Poland
State/province [342] 0 0
Torun
Country [343] 0 0
Poland
State/province [343] 0 0
Warszawa
Country [344] 0 0
Poland
State/province [344] 0 0
Wroclaw
Country [345] 0 0
Poland
State/province [345] 0 0
Zabrze
Country [346] 0 0
Portugal
State/province [346] 0 0
Castelo Branco
Country [347] 0 0
Portugal
State/province [347] 0 0
Lisboa
Country [348] 0 0
Portugal
State/province [348] 0 0
Porto
Country [349] 0 0
Portugal
State/province [349] 0 0
Região Autónoma Da Madeira
Country [350] 0 0
Portugal
State/province [350] 0 0
Santarém
Country [351] 0 0
Portugal
State/province [351] 0 0
Setúbal
Country [352] 0 0
Portugal
State/province [352] 0 0
Almada
Country [353] 0 0
Portugal
State/province [353] 0 0
Amadora
Country [354] 0 0
Portugal
State/province [354] 0 0
Braga
Country [355] 0 0
Portugal
State/province [355] 0 0
Faro
Country [356] 0 0
Portugal
State/province [356] 0 0
Leiria
Country [357] 0 0
Portugal
State/province [357] 0 0
Viana do Castelo
Country [358] 0 0
Puerto Rico
State/province [358] 0 0
Cidra
Country [359] 0 0
Puerto Rico
State/province [359] 0 0
San Juan
Country [360] 0 0
Romania
State/province [360] 0 0
Alba
Country [361] 0 0
Romania
State/province [361] 0 0
Bihor
Country [362] 0 0
Romania
State/province [362] 0 0
Maramures
Country [363] 0 0
Romania
State/province [363] 0 0
Prahova
Country [364] 0 0
Romania
State/province [364] 0 0
Timis
Country [365] 0 0
Romania
State/province [365] 0 0
Brasov
Country [366] 0 0
Romania
State/province [366] 0 0
Bucuresti
Country [367] 0 0
Romania
State/province [367] 0 0
Cluj-Napoca
Country [368] 0 0
Romania
State/province [368] 0 0
Galati
Country [369] 0 0
Romania
State/province [369] 0 0
Iasi
Country [370] 0 0
Romania
State/province [370] 0 0
Oradea
Country [371] 0 0
Romania
State/province [371] 0 0
Satu Mare
Country [372] 0 0
Romania
State/province [372] 0 0
Timisoara
Country [373] 0 0
Russian Federation
State/province [373] 0 0
Arkhangelsk
Country [374] 0 0
Russian Federation
State/province [374] 0 0
Barnaul
Country [375] 0 0
Russian Federation
State/province [375] 0 0
Chelyabinsk
Country [376] 0 0
Russian Federation
State/province [376] 0 0
Irkutsk
Country [377] 0 0
Russian Federation
State/province [377] 0 0
Izhevsk
Country [378] 0 0
Russian Federation
State/province [378] 0 0
Kazan
Country [379] 0 0
Russian Federation
State/province [379] 0 0
Kemerovo
Country [380] 0 0
Russian Federation
State/province [380] 0 0
Kirov
Country [381] 0 0
Russian Federation
State/province [381] 0 0
Krasnodar
Country [382] 0 0
Russian Federation
State/province [382] 0 0
Krasnoyarsk
Country [383] 0 0
Russian Federation
State/province [383] 0 0
Kursk
Country [384] 0 0
Russian Federation
State/province [384] 0 0
Moscow
Country [385] 0 0
Russian Federation
State/province [385] 0 0
Nizhny Novgorod
Country [386] 0 0
Russian Federation
State/province [386] 0 0
Novosibirsk
Country [387] 0 0
Russian Federation
State/province [387] 0 0
Omsk
Country [388] 0 0
Russian Federation
State/province [388] 0 0
Orenburg
Country [389] 0 0
Russian Federation
State/province [389] 0 0
Perm
Country [390] 0 0
Russian Federation
State/province [390] 0 0
Saratov
Country [391] 0 0
Russian Federation
State/province [391] 0 0
St. Petersburg
Country [392] 0 0
Russian Federation
State/province [392] 0 0
Stavropol
Country [393] 0 0
Russian Federation
State/province [393] 0 0
Syktyvkar
Country [394] 0 0
Russian Federation
State/province [394] 0 0
Voronezh
Country [395] 0 0
Russian Federation
State/province [395] 0 0
Yaroslavl
Country [396] 0 0
Russian Federation
State/province [396] 0 0
Yekaterinburg
Country [397] 0 0
Singapore
State/province [397] 0 0
Singapore
Country [398] 0 0
Slovakia
State/province [398] 0 0
Banska Bystrica
Country [399] 0 0
Slovakia
State/province [399] 0 0
Bardejov
Country [400] 0 0
Slovakia
State/province [400] 0 0
Nitra
Country [401] 0 0
Slovakia
State/province [401] 0 0
Rimavska Sobota
Country [402] 0 0
Slovakia
State/province [402] 0 0
Roznava
Country [403] 0 0
Slovakia
State/province [403] 0 0
Zilina
Country [404] 0 0
South Africa
State/province [404] 0 0
Eastern Cape
Country [405] 0 0
South Africa
State/province [405] 0 0
Gauteng
Country [406] 0 0
South Africa
State/province [406] 0 0
Kwazulu-Natal
Country [407] 0 0
South Africa
State/province [407] 0 0
Mpumalanga
Country [408] 0 0
South Africa
State/province [408] 0 0
Western Cape
Country [409] 0 0
Spain
State/province [409] 0 0
A Coruña
Country [410] 0 0
Spain
State/province [410] 0 0
Barcelona
Country [411] 0 0
Spain
State/province [411] 0 0
Cádiz
Country [412] 0 0
Spain
State/province [412] 0 0
Lugo
Country [413] 0 0
Spain
State/province [413] 0 0
Madrid
Country [414] 0 0
Spain
State/province [414] 0 0
Valencia
Country [415] 0 0
Spain
State/province [415] 0 0
Córdoba
Country [416] 0 0
Spain
State/province [416] 0 0
Granada
Country [417] 0 0
Spain
State/province [417] 0 0
Jaén
Country [418] 0 0
Spain
State/province [418] 0 0
Málaga
Country [419] 0 0
Sweden
State/province [419] 0 0
Göteborg
Country [420] 0 0
Sweden
State/province [420] 0 0
Lund
Country [421] 0 0
Sweden
State/province [421] 0 0
Rättvik
Country [422] 0 0
Sweden
State/province [422] 0 0
Skövde
Country [423] 0 0
Sweden
State/province [423] 0 0
Stockholm
Country [424] 0 0
Sweden
State/province [424] 0 0
Uppsala
Country [425] 0 0
Sweden
State/province [425] 0 0
Örebro
Country [426] 0 0
Switzerland
State/province [426] 0 0
Sankt Gallen
Country [427] 0 0
Switzerland
State/province [427] 0 0
Solothurn
Country [428] 0 0
Switzerland
State/province [428] 0 0
Vaud
Country [429] 0 0
Switzerland
State/province [429] 0 0
Bern
Country [430] 0 0
Switzerland
State/province [430] 0 0
Genève
Country [431] 0 0
Taiwan
State/province [431] 0 0
Changhua
Country [432] 0 0
Taiwan
State/province [432] 0 0
Kaohsiung
Country [433] 0 0
Taiwan
State/province [433] 0 0
New Taipei City
Country [434] 0 0
Taiwan
State/province [434] 0 0
Taichung
Country [435] 0 0
Taiwan
State/province [435] 0 0
Taipei
Country [436] 0 0
Taiwan
State/province [436] 0 0
Taoyuan
Country [437] 0 0
Thailand
State/province [437] 0 0
Bangkok
Country [438] 0 0
Thailand
State/province [438] 0 0
Chiangmai
Country [439] 0 0
Thailand
State/province [439] 0 0
Khon Kaen
Country [440] 0 0
Turkey
State/province [440] 0 0
Ankara
Country [441] 0 0
Turkey
State/province [441] 0 0
Antalya
Country [442] 0 0
Turkey
State/province [442] 0 0
Aydin
Country [443] 0 0
Turkey
State/province [443] 0 0
Istanbul
Country [444] 0 0
Turkey
State/province [444] 0 0
Izmir
Country [445] 0 0
Turkey
State/province [445] 0 0
Kayseri
Country [446] 0 0
Turkey
State/province [446] 0 0
Kocaeli
Country [447] 0 0
Turkey
State/province [447] 0 0
Malatya
Country [448] 0 0
Turkey
State/province [448] 0 0
Sivas
Country [449] 0 0
Ukraine
State/province [449] 0 0
Cherkasy
Country [450] 0 0
Ukraine
State/province [450] 0 0
Chernivtsi
Country [451] 0 0
Ukraine
State/province [451] 0 0
Dnipro
Country [452] 0 0
Ukraine
State/province [452] 0 0
Ivano-Frankivsk
Country [453] 0 0
Ukraine
State/province [453] 0 0
Kharkiv
Country [454] 0 0
Ukraine
State/province [454] 0 0
Kiev
Country [455] 0 0
Ukraine
State/province [455] 0 0
Kyiv
Country [456] 0 0
Ukraine
State/province [456] 0 0
Lviv
Country [457] 0 0
Ukraine
State/province [457] 0 0
Mykolayiv
Country [458] 0 0
Ukraine
State/province [458] 0 0
Ternopil
Country [459] 0 0
Ukraine
State/province [459] 0 0
Vinnytsia
Country [460] 0 0
Ukraine
State/province [460] 0 0
Zaporizhzhya
Country [461] 0 0
Ukraine
State/province [461] 0 0
Zaporozhye
Country [462] 0 0
United Kingdom
State/province [462] 0 0
Carmarthenshire
Country [463] 0 0
United Kingdom
State/province [463] 0 0
Merseyside
Country [464] 0 0