Please note the ANZCTR will be unattended from Friday 20 December 2024 for the holidays. The Registry will re-open on Tuesday 7 January 2025. Submissions and updates will not be processed during that time.

Registering a new trial?

To achieve prospective registration, we recommend submitting your trial for registration at the same time as ethics submission.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT01313676




Registration number
NCT01313676
Ethics application status
Date submitted
3/02/2011
Date registered
14/03/2011
Date last updated
6/08/2018

Titles & IDs
Public title
Study to Evaluate the Effect of Fluticasone Furoate/Vilanterol on Survival in Subjects With Chronic Obstructive Pulmonary Disease
Scientific title
A Clinical Outcomes Study to Compare the Effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25mcg With Placebo on Survival in Subjects With Moderate Chronic Obstructive Pulmonary Disease (COPD) and a History of or at Increased Risk for Cardiovascular Disease
Secondary ID [1] 0 0
113782
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Pulmonary Disease, Chronic Obstructive 0 0
Condition category
Condition code
Respiratory 0 0 0 0
Chronic obstructive pulmonary disease

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - fluticasone furoate/vilanterol
Treatment: Drugs - fluticasone furoate
Treatment: Drugs - vilanterol
Other interventions - Placebo

Experimental: fluticasone furoate/vilanterol - Combination of both products in one inhaler

Experimental: fluticasone furoate - comparator of individual component

Experimental: vilanterol - comparator of individual component

Placebo comparator: placebo - once daily via inhaler


Treatment: Drugs: fluticasone furoate/vilanterol
100/25mcg given once daily via novel dry powder inhaler

Treatment: Drugs: fluticasone furoate
100mcg given once daily via novel dry powder inhaler

Treatment: Drugs: vilanterol
25mcg given once daily via novel dry powder inhaler

Other interventions: Placebo
placebo comparator once daily via novel dry powder inhaler

Intervention code [1] 0 0
Treatment: Drugs
Intervention code [2] 0 0
Other interventions
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Number of Participants With Death (Both on and Off Treatment) Due to Any Cause, Time up to or on the Pre-determined Common End Date
Timepoint [1] 0 0
From the date of randomization until date of death due to any cause (average of 2 study years)
Secondary outcome [1] 0 0
Decline in Forced Expiratory Volume in 1 Second (FEV1)
Timepoint [1] 0 0
From start date of IP until IP stop date + 1 (assessed up to 4 years)
Secondary outcome [2] 0 0
Number of Participants With First On-treatment Cardiovascular (CV) Composite Events Occured on or Before Common End Date
Timepoint [2] 0 0
From the start of IP to first on treatment CV event till 7 days after the last dose of IP (average of 2 study years)

Eligibility
Key inclusion criteria
* Type of subject: outpatient.
* Informed consent: Subjects must give their signed and dated written informed consent to participate.
* Gender: Male or female. Female subjects must be post-menopausal or using a highly effective method for avoidance of pregnancy. The decision to include or exclude women of childbearing potential may be made at the discretion of the investigator in accordance with local practice in relation to adequate contraception.
* Age: >=40 and <=80 years of age at Screening (Visit 1).
* Tobacco use: Subjects with a current or prior history of >=10 pack-years of cigarette smoking at screening (Visit 1). Previous smokers are defined as those who have stopped smoking for at least 6 months prior to Visit 1.
* Airflow Obstruction:

Subjects with a measured post-albuterol/salbutamol forced expiratory volume in 1 second (FEV1)/(forced vital capacity)FVC ratio of <=0.70 at Screening (Visit 1).

Subjects with a measured post-albuterol/salbutamol FEV1 >=50 and <=70% of predicted normal values calculated using NHANES III reference equations [Hankinson, 1999; Hankinson, 2010] at Screening (Visit 1).

Post-bronchodilator spirometry will be performed approximately 15 minutes after the subject has self-administered 4 inhalations (i.e., total 400mcg) of albuterol/salbutamol via a metered dose inhaler (MDI )with a valved-holding chamber. The FEV1/FVC ratio and FEV1 percent predicted values will be calculated.

* Symptoms of COPD: Subjects must score 2 or higher on the modified Medical Research Council Dyspnea scale (Visit 1)
* Cardiovascular disease:

For patients >= 40 years of age: any one of the following:

Established (i.e. by clinical signs or imaging studies) coronary artery disease (CAD) Established (i.e. by clinical signs or imaging studies) peripheral vascular disease (PVD) Previous stroke Previous MI Diabetes mellitus with target organ disease OR

For patients >=60 years of age: any 2 of the following:

Being treated for hypercholesterolemia Being treated for hypertension Being treated for diabetes mellitus Being treated for peripheral vascular disease
Minimum age
40 Years
Maximum age
80 Years
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Pregnancy: Women who are pregnant or lactating.
* Asthma: Subjects with a current diagnosis of asthma. (Subjects with a prior history of asthma are eligible if they also have a current diagnosis of COPD).
* alpha 1-antitrypsin deficiency: Subjects with known alpha-1 antitrypsin deficiency as the underlying cause of COPD.
* Other respiratory disorders: Subjects with active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, pulmonary fibrosis, pulmonary hypertension, interstitial lung diseases or other active pulmonary diseases.
* Lung resection or transplantation: Subjects with lung volume reduction surgery within the 12 months prior to Screening or having had a lung transplant.
* A moderate/severe COPD exacerbation that has not resolved at least 14 days prior to Visit 1 and at least 30 days following the last dose of oral corticosteroids (if applicable).
* Current severe heart failure (New York Heart Association class IV). Subjects will also be excluded if they have a known ejection fraction of <30% or if they have an implantable cardioverter defibrillator (ICD).
* Other diseases/abnormalities: Any life-threatening condition with life expectancy <3 years, other than vascular disease or COPD, that might prevent the subject from completing the study.
* End stage chronic renal disease: Subjects will be excluded if on renal replacement therapy (hemodialysis or peritoneal).
* Drug/food allergy: Subjects with a history of hypersensitivity to any of the study medications (e.g. beta-agonists, corticosteroid) or components of the inhalation powder (e.g. lactose, magnesium stearate). In addition, patients with a history of severe milk protein allergy that, in the opinion of the study physician, contraindicates the subject's participation will also be excluded.
* Drug/alcohol abuse: Subjects with a known or suspected history of alcohol or drug abuse within the last 2 years.
* Oxygen therapy: Subjects receiving treatment with long-term oxygen therapy (LTOT) or nocturnal oxygen therapy required for greater than 12 hours a day. Oxygen prn use (i.e. <=12 hours per day) is not exclusionary.
* Questionable validity of consent: Subjects with a history of psychiatric disease, intellectual deficiency, poor motivation or other conditions that will limit the validity of informed consent to participate in the study or the potential compliance to study procedures.
* Affiliation with investigator site: Study investigators, sub-investigators, study coordinators, employees of a participating investigator or immediate family members of the aforementioned are excluded from participating in this study.
* Additional medication: Use of the following medications within the following time intervals prior to Visit 1 or during the study (unless otherwise specified):

Medication No use within the following time intervals prior to Screening or thereafter at any time during the study (unless otherwise specified) Inhaled Long acting beta-agonists (LABA) 48 hours ICS/LABA combination products 48 hours Inhaled corticosteroids 48 hours Tiotropium 1 week Systemic, Oral, parenteral, intra-articular corticosteroids 30 days (oral and systemic corticosteroids may be used to treat COPD exacerbations during the study) Cytochrome P450 3A4 strong inhibitors including but not limited to antiretrovirals (protease inhibitors) (e.g.Indinavir, Nelfinavir, Ritonavir, Saquinavir); Imidazole and Triazole anti-fungals (e.g. Ketaconazole, Itraconazole); Clarithromycin, Telithromycin, Amiodarone, and Nefazodone 6 weeks Grapefruit is allowed up to Visit 1, then limited to no more than one glass of grapefruit juice (250 mL/ 8 ounces) or one grapefruit per day Any other investigational drug 30 days or 5 half lives whichever is longer.

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
QLD,SA,VIC
Recruitment hospital [1] 0 0
GSK Investigational Site - Cairns
Recruitment hospital [2] 0 0
GSK Investigational Site - Redcliffe
Recruitment hospital [3] 0 0
GSK Investigational Site - Bedford Park
Recruitment hospital [4] 0 0
GSK Investigational Site - Daw Park
Recruitment hospital [5] 0 0
GSK Investigational Site - Footscray
Recruitment hospital [6] 0 0
GSK Investigational Site - Geelong
Recruitment hospital [7] 0 0
GSK Investigational Site - Melbourne
Recruitment hospital [8] 0 0
GSK Investigational Site - Glen Osmond
Recruitment postcode(s) [1] 0 0
4870 - Cairns
Recruitment postcode(s) [2] 0 0
4020 - Redcliffe
Recruitment postcode(s) [3] 0 0
5042 - Bedford Park
Recruitment postcode(s) [4] 0 0
5041 - Daw Park
Recruitment postcode(s) [5] 0 0
3011 - Footscray
Recruitment postcode(s) [6] 0 0
3220 - Geelong
Recruitment postcode(s) [7] 0 0
3004 - Melbourne
Recruitment postcode(s) [8] 0 0
5064 - Glen Osmond
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
Arkansas
Country [4] 0 0
United States of America
State/province [4] 0 0
California
Country [5] 0 0
United States of America
State/province [5] 0 0
Colorado
Country [6] 0 0
United States of America
State/province [6] 0 0
Connecticut
Country [7] 0 0
United States of America
State/province [7] 0 0
District of Columbia
Country [8] 0 0
United States of America
State/province [8] 0 0
Florida
Country [9] 0 0
United States of America
State/province [9] 0 0
Georgia
Country [10] 0 0
United States of America
State/province [10] 0 0
Hawaii
Country [11] 0 0
United States of America
State/province [11] 0 0
Idaho
Country [12] 0 0
United States of America
State/province [12] 0 0
Illinois
Country [13] 0 0
United States of America
State/province [13] 0 0
Indiana
Country [14] 0 0
United States of America
State/province [14] 0 0
Iowa
Country [15] 0 0
United States of America
State/province [15] 0 0
Kansas
Country [16] 0 0
United States of America
State/province [16] 0 0
Kentucky
Country [17] 0 0
United States of America
State/province [17] 0 0
Louisiana
Country [18] 0 0
United States of America
State/province [18] 0 0
Maine
Country [19] 0 0
United States of America
State/province [19] 0 0
Maryland
Country [20] 0 0
United States of America
State/province [20] 0 0
Massachusetts
Country [21] 0 0
United States of America
State/province [21] 0 0
Michigan
Country [22] 0 0
United States of America
State/province [22] 0 0
Minnesota
Country [23] 0 0
United States of America
State/province [23] 0 0
Missouri
Country [24] 0 0
United States of America
State/province [24] 0 0
Montana
Country [25] 0 0
United States of America
State/province [25] 0 0
Nebraska
Country [26] 0 0
United States of America
State/province [26] 0 0
Nevada
Country [27] 0 0
United States of America
State/province [27] 0 0
New Jersey
Country [28] 0 0
United States of America
State/province [28] 0 0
New Mexico
Country [29] 0 0
United States of America
State/province [29] 0 0
New York
Country [30] 0 0
United States of America
State/province [30] 0 0
North Carolina
Country [31] 0 0
United States of America
State/province [31] 0 0
Ohio
Country [32] 0 0
United States of America
State/province [32] 0 0
Oklahoma
Country [33] 0 0
United States of America
State/province [33] 0 0
Oregon
Country [34] 0 0
United States of America
State/province [34] 0 0
Pennsylvania
Country [35] 0 0
United States of America
State/province [35] 0 0
Rhode Island
Country [36] 0 0
United States of America
State/province [36] 0 0
South Carolina
Country [37] 0 0
United States of America
State/province [37] 0 0
South Dakota
Country [38] 0 0
United States of America
State/province [38] 0 0
Tennessee
Country [39] 0 0
United States of America
State/province [39] 0 0
Texas
Country [40] 0 0
United States of America
State/province [40] 0 0
Utah
Country [41] 0 0
United States of America
State/province [41] 0 0
Virginia
Country [42] 0 0
United States of America
State/province [42] 0 0
Washington
Country [43] 0 0
United States of America
State/province [43] 0 0
West Virginia
Country [44] 0 0
United States of America
State/province [44] 0 0
Wisconsin
Country [45] 0 0
Argentina
State/province [45] 0 0
Buenos Aires
Country [46] 0 0
Argentina
State/province [46] 0 0
Córdova
Country [47] 0 0
Argentina
State/province [47] 0 0
Entre Ríos
Country [48] 0 0
Argentina
State/province [48] 0 0
Mendoza
Country [49] 0 0
Argentina
State/province [49] 0 0
Río Negro
Country [50] 0 0
Argentina
State/province [50] 0 0
Santa Fe
Country [51] 0 0
Argentina
State/province [51] 0 0
Tucumán
Country [52] 0 0
Argentina
State/province [52] 0 0
Ciudad Autonoma de Buenos Aires
Country [53] 0 0
Argentina
State/province [53] 0 0
Ciudad Autónoma de Buenos Aires
Country [54] 0 0
Argentina
State/province [54] 0 0
Cordoba
Country [55] 0 0
Argentina
State/province [55] 0 0
Coronel Suarez
Country [56] 0 0
Argentina
State/province [56] 0 0
Corrientes
Country [57] 0 0
Argentina
State/province [57] 0 0
Florencio Varela
Country [58] 0 0
Argentina
State/province [58] 0 0
Formosa
Country [59] 0 0
Argentina
State/province [59] 0 0
Jujuy
Country [60] 0 0
Argentina
State/province [60] 0 0
Lanús
Country [61] 0 0
Argentina
State/province [61] 0 0
Mar del Plata
Country [62] 0 0
Argentina
State/province [62] 0 0
Monte Grande
Country [63] 0 0
Argentina
State/province [63] 0 0
Rosario
Country [64] 0 0
Argentina
State/province [64] 0 0
Salta
Country [65] 0 0
Argentina
State/province [65] 0 0
San Luis
Country [66] 0 0
Argentina
State/province [66] 0 0
San Miguel de Tucuman
Country [67] 0 0
Argentina
State/province [67] 0 0
San Miguel de Tucumán
Country [68] 0 0
Argentina
State/province [68] 0 0
Santiago del Estero
Country [69] 0 0
Austria
State/province [69] 0 0
Feldbach
Country [70] 0 0
Austria
State/province [70] 0 0
Feldkirch
Country [71] 0 0
Austria
State/province [71] 0 0
Grieskirchen
Country [72] 0 0
Austria
State/province [72] 0 0
Innsbruck
Country [73] 0 0
Austria
State/province [73] 0 0
Linz
Country [74] 0 0
Austria
State/province [74] 0 0
Salzburg
Country [75] 0 0
Austria
State/province [75] 0 0
Spittal/Drau
Country [76] 0 0
Austria
State/province [76] 0 0
Thalheim bei Wels
Country [77] 0 0
Austria
State/province [77] 0 0
Vienna
Country [78] 0 0
Austria
State/province [78] 0 0
Wels
Country [79] 0 0
Austria
State/province [79] 0 0
Zwettl
Country [80] 0 0
Belarus
State/province [80] 0 0
Brest
Country [81] 0 0
Belarus
State/province [81] 0 0
Gomel
Country [82] 0 0
Belarus
State/province [82] 0 0
Grodno
Country [83] 0 0
Belarus
State/province [83] 0 0
Minsk
Country [84] 0 0
Belarus
State/province [84] 0 0
Vitebsk
Country [85] 0 0
Belgium
State/province [85] 0 0
Diest
Country [86] 0 0
Belgium
State/province [86] 0 0
Erpent
Country [87] 0 0
Belgium
State/province [87] 0 0
Gilly
Country [88] 0 0
Belgium
State/province [88] 0 0
Mons
Country [89] 0 0
Belgium
State/province [89] 0 0
Namur
Country [90] 0 0
Bosnia and Herzegovina
State/province [90] 0 0
Banja Luka
Country [91] 0 0
Bosnia and Herzegovina
State/province [91] 0 0
Banjaluka
Country [92] 0 0
Bosnia and Herzegovina
State/province [92] 0 0
Bihac
Country [93] 0 0
Bosnia and Herzegovina
State/province [93] 0 0
Bijeljina
Country [94] 0 0
Bosnia and Herzegovina
State/province [94] 0 0
Brcko
Country [95] 0 0
Bosnia and Herzegovina
State/province [95] 0 0
Foca
Country [96] 0 0
Bosnia and Herzegovina
State/province [96] 0 0
Gracanica
Country [97] 0 0
Bosnia and Herzegovina
State/province [97] 0 0
Gradiska
Country [98] 0 0
Bosnia and Herzegovina
State/province [98] 0 0
Istocno Sarajevo
Country [99] 0 0
Bosnia and Herzegovina
State/province [99] 0 0
Konjic
Country [100] 0 0
Bosnia and Herzegovina
State/province [100] 0 0
Mostar
Country [101] 0 0
Bosnia and Herzegovina
State/province [101] 0 0
Novi Travnik
Country [102] 0 0
Bosnia and Herzegovina
State/province [102] 0 0
Pale
Country [103] 0 0
Bosnia and Herzegovina
State/province [103] 0 0
Sarajevo
Country [104] 0 0
Bosnia and Herzegovina
State/province [104] 0 0
Srebrenik
Country [105] 0 0
Bosnia and Herzegovina
State/province [105] 0 0
Tesanj
Country [106] 0 0
Bosnia and Herzegovina
State/province [106] 0 0
Teslic
Country [107] 0 0
Bosnia and Herzegovina
State/province [107] 0 0
Travnik
Country [108] 0 0
Bosnia and Herzegovina
State/province [108] 0 0
Trebinje
Country [109] 0 0
Bosnia and Herzegovina
State/province [109] 0 0
Tuzla
Country [110] 0 0
Bosnia and Herzegovina
State/province [110] 0 0
Visegrad
Country [111] 0 0
Bosnia and Herzegovina
State/province [111] 0 0
Zenica
Country [112] 0 0
Bulgaria
State/province [112] 0 0
Blagoevgrad
Country [113] 0 0
Bulgaria
State/province [113] 0 0
Dimitrovgrad
Country [114] 0 0
Bulgaria
State/province [114] 0 0
Gabrovo
Country [115] 0 0
Bulgaria
State/province [115] 0 0
Kozlodui
Country [116] 0 0
Bulgaria
State/province [116] 0 0
Lovech
Country [117] 0 0
Bulgaria
State/province [117] 0 0
Pazardjik
Country [118] 0 0
Bulgaria
State/province [118] 0 0
Petrich
Country [119] 0 0
Bulgaria
State/province [119] 0 0
Pleven
Country [120] 0 0
Bulgaria
State/province [120] 0 0
Plovdiv
Country [121] 0 0
Bulgaria
State/province [121] 0 0
Razgrad
Country [122] 0 0
Bulgaria
State/province [122] 0 0
Rousse
Country [123] 0 0
Bulgaria
State/province [123] 0 0
Sevlievo
Country [124] 0 0
Bulgaria
State/province [124] 0 0
Sliven
Country [125] 0 0
Bulgaria
State/province [125] 0 0
Sofia
Country [126] 0 0
Bulgaria
State/province [126] 0 0
Stara Zagora
Country [127] 0 0
Bulgaria
State/province [127] 0 0
Troyan
Country [128] 0 0
Bulgaria
State/province [128] 0 0
Varna
Country [129] 0 0
Bulgaria
State/province [129] 0 0
Veliko Tarnovo
Country [130] 0 0
Bulgaria
State/province [130] 0 0
Vidin
Country [131] 0 0
Canada
State/province [131] 0 0
Alberta
Country [132] 0 0
Canada
State/province [132] 0 0
British Columbia
Country [133] 0 0
Canada
State/province [133] 0 0
Manitoba
Country [134] 0 0
Canada
State/province [134] 0 0
Ontario
Country [135] 0 0
Canada
State/province [135] 0 0
Quebec
Country [136] 0 0
Chile
State/province [136] 0 0
Región De La Araucania
Country [137] 0 0
Chile
State/province [137] 0 0
Región Metro De Santiago
Country [138] 0 0
Chile
State/province [138] 0 0
Valparaíso
Country [139] 0 0
China
State/province [139] 0 0
Guangdong
Country [140] 0 0
China
State/province [140] 0 0
Guangxi
Country [141] 0 0
China
State/province [141] 0 0
Hainan
Country [142] 0 0
China
State/province [142] 0 0
Hebei
Country [143] 0 0
China
State/province [143] 0 0
Hubei
Country [144] 0 0
China
State/province [144] 0 0
Inner Mongolia
Country [145] 0 0
China
State/province [145] 0 0
Liaoning
Country [146] 0 0
China
State/province [146] 0 0
Ningxia
Country [147] 0 0
China
State/province [147] 0 0
Shaanxi
Country [148] 0 0
China
State/province [148] 0 0
Shandong
Country [149] 0 0
China
State/province [149] 0 0
Shanxi
Country [150] 0 0
China
State/province [150] 0 0
Sichuan
Country [151] 0 0
China
State/province [151] 0 0
Baotou
Country [152] 0 0
China
State/province [152] 0 0
Beijing
Country [153] 0 0
China
State/province [153] 0 0
Bengbu
Country [154] 0 0
China
State/province [154] 0 0
Changchun
Country [155] 0 0
China
State/province [155] 0 0
Chengdu
Country [156] 0 0
China
State/province [156] 0 0
Chongqing
Country [157] 0 0
China
State/province [157] 0 0
Fu Zhou
Country [158] 0 0
China
State/province [158] 0 0
Fuzhou
Country [159] 0 0
China
State/province [159] 0 0
Guangzhou
Country [160] 0 0
China
State/province [160] 0 0
Hangzhou
Country [161] 0 0
China
State/province [161] 0 0
Hefei
Country [162] 0 0
China
State/province [162] 0 0
Huai'an
Country [163] 0 0
China
State/province [163] 0 0
Jiangyin
Country [164] 0 0
China
State/province [164] 0 0
Luzhou
Country [165] 0 0
China
State/province [165] 0 0
Nanchang
Country [166] 0 0
China
State/province [166] 0 0
Nanjing
Country [167] 0 0
China
State/province [167] 0 0
Shanghai
Country [168] 0 0
China
State/province [168] 0 0
ShangHai
Country [169] 0 0
China
State/province [169] 0 0
Tianjin
Country [170] 0 0
China
State/province [170] 0 0
Wuxi
Country [171] 0 0
Colombia
State/province [171] 0 0
Barranquilla
Country [172] 0 0
Colombia
State/province [172] 0 0
Bogota
Country [173] 0 0
Colombia
State/province [173] 0 0
Bogotá
Country [174] 0 0
Colombia
State/province [174] 0 0
Cali
Country [175] 0 0
Colombia
State/province [175] 0 0
Medellin
Country [176] 0 0
Colombia
State/province [176] 0 0
Zipaquira
Country [177] 0 0
Croatia
State/province [177] 0 0
Cakovec
Country [178] 0 0
Croatia
State/province [178] 0 0
Draganic
Country [179] 0 0
Croatia
State/province [179] 0 0
Hrasce Turopoljsko
Country [180] 0 0
Croatia
State/province [180] 0 0
Hreljin
Country [181] 0 0
Croatia
State/province [181] 0 0
Ivankovo
Country [182] 0 0
Croatia
State/province [182] 0 0
Karlovac
Country [183] 0 0
Croatia
State/province [183] 0 0
Klenovnik
Country [184] 0 0
Croatia
State/province [184] 0 0
Krapina
Country [185] 0 0
Croatia
State/province [185] 0 0
Kutina
Country [186] 0 0
Croatia
State/province [186] 0 0
Novi Marof
Country [187] 0 0
Croatia
State/province [187] 0 0
Osijek
Country [188] 0 0
Croatia
State/province [188] 0 0
Retkovci
Country [189] 0 0
Croatia
State/province [189] 0 0
Rijeka
Country [190] 0 0
Croatia
State/province [190] 0 0
Samobor
Country [191] 0 0
Croatia
State/province [191] 0 0
Senj
Country [192] 0 0
Croatia
State/province [192] 0 0
Sibenik
Country [193] 0 0
Croatia
State/province [193] 0 0
Sisak
Country [194] 0 0
Croatia
State/province [194] 0 0
Split
Country [195] 0 0
Croatia
State/province [195] 0 0
Strmec Samoborski
Country [196] 0 0
Croatia
State/province [196] 0 0
Stubicke toplice
Country [197] 0 0
Croatia
State/province [197] 0 0
Sukosan
Country [198] 0 0
Croatia
State/province [198] 0 0
Varazdin
Country [199] 0 0
Croatia
State/province [199] 0 0
Zabok
Country [200] 0 0
Croatia
State/province [200] 0 0
Zadar
Country [201] 0 0
Croatia
State/province [201] 0 0
Zagreb
Country [202] 0 0
Czechia
State/province [202] 0 0
Benesov
Country [203] 0 0
Czechia
State/province [203] 0 0
Beroun
Country [204] 0 0
Czechia
State/province [204] 0 0
Brno
Country [205] 0 0
Czechia
State/province [205] 0 0
Havlickuv brod
Country [206] 0 0
Czechia
State/province [206] 0 0
Hlucin
Country [207] 0 0
Czechia
State/province [207] 0 0
Holesov
Country [208] 0 0
Czechia
State/province [208] 0 0
Jaromer
Country [209] 0 0
Czechia
State/province [209] 0 0
Jindrichuv Hradec
Country [210] 0 0
Czechia
State/province [210] 0 0
Kolin
Country [211] 0 0
Czechia
State/province [211] 0 0
Kralupy nad Vltavou
Country [212] 0 0
Czechia
State/province [212] 0 0
Kromeriz
Country [213] 0 0
Czechia
State/province [213] 0 0
Liberec
Country [214] 0 0
Czechia
State/province [214] 0 0
Melnik
Country [215] 0 0
Czechia
State/province [215] 0 0
Moravsky Krumlov
Country [216] 0 0
Czechia
State/province [216] 0 0
Neratovice
Country [217] 0 0
Czechia
State/province [217] 0 0
Novy Jicin
Country [218] 0 0
Czechia
State/province [218] 0 0
Ostrava - Belsky les
Country [219] 0 0
Czechia
State/province [219] 0 0
Ostrava - Poruba
Country [220] 0 0
Czechia
State/province [220] 0 0
Ostrava
Country [221] 0 0
Czechia
State/province [221] 0 0
Plzen
Country [222] 0 0
Czechia
State/province [222] 0 0
Praha 13
Country [223] 0 0
Czechia
State/province [223] 0 0
Praha 17
Country [224] 0 0
Czechia
State/province [224] 0 0
Praha 1
Country [225] 0 0
Czechia
State/province [225] 0 0
Praha 3
Country [226] 0 0
Czechia
State/province [226] 0 0
Praha 4
Country [227] 0 0
Czechia
State/province [227] 0 0
Praha 5
Country [228] 0 0
Czechia
State/province [228] 0 0
Praha 6
Country [229] 0 0
Czechia
State/province [229] 0 0
Rokycany
Country [230] 0 0
Czechia
State/province [230] 0 0
Rudna
Country [231] 0 0
Czechia
State/province [231] 0 0
Strakonice
Country [232] 0 0
Czechia
State/province [232] 0 0
Svitavy
Country [233] 0 0
Czechia
State/province [233] 0 0
Tremosna
Country [234] 0 0
Czechia
State/province [234] 0 0
Usti Nad Labem - Klise
Country [235] 0 0
Czechia
State/province [235] 0 0
Zatec
Country [236] 0 0
France
State/province [236] 0 0
Ferolles Attilly
Country [237] 0 0
France
State/province [237] 0 0
Paris Cedex 04
Country [238] 0 0
France
State/province [238] 0 0
Strasbourg Cedex
Country [239] 0 0
France
State/province [239] 0 0
Tarbes
Country [240] 0 0
France
State/province [240] 0 0
Toulouse cedex 9
Country [241] 0 0
Georgia
State/province [241] 0 0
Batumi
Country [242] 0 0
Georgia
State/province [242] 0 0
Gurjaani
Country [243] 0 0
Georgia
State/province [243] 0 0
Kutaisi
Country [244] 0 0
Georgia
State/province [244] 0 0
Kvemo Kartli
Country [245] 0 0
Georgia
State/province [245] 0 0
Tbilisi
Country [246] 0 0
Germany
State/province [246] 0 0
Baden-Wuerttemberg
Country [247] 0 0
Germany
State/province [247] 0 0
Bayern
Country [248] 0 0
Germany
State/province [248] 0 0
Brandenburg
Country [249] 0 0
Germany
State/province [249] 0 0
Hessen
Country [250] 0 0
Germany
State/province [250] 0 0
Niedersachsen
Country [251] 0 0
Germany
State/province [251] 0 0
Nordrhein-Westfalen
Country [252] 0 0
Germany
State/province [252] 0 0
Rheinland-Pfalz
Country [253] 0 0
Germany
State/province [253] 0 0
Sachsen-Anhalt
Country [254] 0 0
Germany
State/province [254] 0 0
Sachsen
Country [255] 0 0
Germany
State/province [255] 0 0
Schleswig-Holstein
Country [256] 0 0
Germany
State/province [256] 0 0
Thueringen
Country [257] 0 0
Germany
State/province [257] 0 0
Berlin
Country [258] 0 0
Germany
State/province [258] 0 0
Hamburg
Country [259] 0 0
Germany
State/province [259] 0 0
München
Country [260] 0 0
Greece
State/province [260] 0 0
Athens
Country [261] 0 0
Greece
State/province [261] 0 0
Thessaloniki
Country [262] 0 0
Hungary
State/province [262] 0 0
Balassagyarmat
Country [263] 0 0
Hungary
State/province [263] 0 0
Budapest
Country [264] 0 0
Hungary
State/province [264] 0 0
Debrecen
Country [265] 0 0
Hungary
State/province [265] 0 0
Gyula
Country [266] 0 0
Hungary
State/province [266] 0 0
Kaposvár
Country [267] 0 0
Hungary
State/province [267] 0 0
Komarom
Country [268] 0 0
Hungary
State/province [268] 0 0
Komló
Country [269] 0 0
Hungary
State/province [269] 0 0
Mosonmagyaróvár
Country [270] 0 0
Hungary
State/province [270] 0 0
Nagykanizsa
Country [271] 0 0
Hungary
State/province [271] 0 0
Nyiregyhaza
Country [272] 0 0
Hungary
State/province [272] 0 0
Pécs
Country [273] 0 0
Hungary
State/province [273] 0 0
Sopron
Country [274] 0 0
Hungary
State/province [274] 0 0
Szigetszentmiklos
Country [275] 0 0
Hungary
State/province [275] 0 0
Szikszó
Country [276] 0 0
Hungary
State/province [276] 0 0
Szombathely
Country [277] 0 0
Hungary
State/province [277] 0 0
Tatabanya
Country [278] 0 0
Hungary
State/province [278] 0 0
Vasarosnameny
Country [279] 0 0
Hungary
State/province [279] 0 0
Zalaegerszeg
Country [280] 0 0
India
State/province [280] 0 0
Ahmedabad
Country [281] 0 0
India
State/province [281] 0 0
Alappuzha
Country [282] 0 0
India
State/province [282] 0 0
Angamaly
Country [283] 0 0
India
State/province [283] 0 0
Aurangabad
Country [284] 0 0
India
State/province [284] 0 0
Bangalore
Country [285] 0 0
India
State/province [285] 0 0
Chennai
Country [286] 0 0
India
State/province [286] 0 0
Guntur
Country [287] 0 0
India
State/province [287] 0 0
Hyderabad
Country [288] 0 0
India
State/province [288] 0 0
Jaipur
Country [289] 0 0
India
State/province [289] 0 0
Lucknow
Country [290] 0 0
India
State/province [290] 0 0
Mysore
Country [291] 0 0
India
State/province [291] 0 0
Nagpur
Country [292] 0 0
India
State/province [292] 0 0
Nashik
Country [293] 0 0
India
State/province [293] 0 0
Nasik
Country [294] 0 0
India
State/province [294] 0 0
Pune
Country [295] 0 0
India
State/province [295] 0 0
Trisshur
Country [296] 0 0
India
State/province [296] 0 0
Trivandrum
Country [297] 0 0
India
State/province [297] 0 0
Varanasi
Country [298] 0 0
India
State/province [298] 0 0
Vijayawada
Country [299] 0 0
Indonesia
State/province [299] 0 0
Banda Aceh
Country [300] 0 0
Indonesia
State/province [300] 0 0
Banjarmasin
Country [301] 0 0
Indonesia
State/province [301] 0 0
Bukittinggi
Country [302] 0 0
Indonesia
State/province [302] 0 0
Denpasar
Country [303] 0 0
Indonesia
State/province [303] 0 0
Depok Timur
Country [304] 0 0
Indonesia
State/province [304] 0 0
Jakarta
Country [305] 0 0
Indonesia
State/province [305] 0 0
Lampung Selatan
Country [306] 0 0
Indonesia
State/province [306] 0 0
Makassar
Country [307] 0 0
Indonesia
State/province [307] 0 0
Malang
Country [308] 0 0
Indonesia
State/province [308] 0 0
Medan
Country [309] 0 0
Indonesia
State/province [309] 0 0
Padang
Country [310] 0 0
Indonesia
State/province [310] 0 0
Palembang
Country [311] 0 0
Indonesia
State/province [311] 0 0
Pekanbaru
Country [312] 0 0
Indonesia
State/province [312] 0 0
Pontianak
Country [313] 0 0
Indonesia
State/province [313] 0 0
Pringsewu
Country [314] 0 0
Indonesia
State/province [314] 0 0
Semarang
Country [315] 0 0
Indonesia
State/province [315] 0 0
Surabaya
Country [316] 0 0
Indonesia
State/province [316] 0 0
Surakarta
Country [317] 0 0
Indonesia
State/province [317] 0 0
Yogyakarta
Country [318] 0 0
Israel
State/province [318] 0 0
Afula
Country [319] 0 0
Israel
State/province [319] 0 0
Ashkelon
Country [320] 0 0
Israel
State/province [320] 0 0
Beer-Sheba
Country [321] 0 0
Israel
State/province [321] 0 0
Hadera
Country [322] 0 0
Israel
State/province [322] 0 0
Haifa
Country [323] 0 0
Israel
State/province [323] 0 0
Holon
Country [324] 0 0
Israel
State/province [324] 0 0
Jerusalem
Country [325] 0 0
Israel
State/province [325] 0 0
Kfar Saba
Country [326] 0 0
Israel
State/province [326] 0 0
Rehovot
Country [327] 0 0
Israel
State/province [327] 0 0
Tel Aviv
Country [328] 0 0
Israel
State/province [328] 0 0
Tel Hashomer
Country [329] 0 0
Italy
State/province [329] 0 0
Friuli-Venezia-Giulia
Country [330] 0 0
Japan
State/province [330] 0 0
Aichi
Country [331] 0 0
Japan
State/province [331] 0 0
Fukuoka
Country [332] 0 0
Japan
State/province [332] 0 0
Gifu
Country [333] 0 0
Japan
State/province [333] 0 0
Hokkaido
Country [334] 0 0
Japan
State/province [334] 0 0
Hyogo
Country [335] 0 0
Japan
State/province [335] 0 0
Ibaraki
Country [336] 0 0
Japan
State/province [336] 0 0
Kagawa
Country [337] 0 0
Japan
State/province [337] 0 0
Kodaira
Country [338] 0 0
Japan
State/province [338] 0 0
Kumamoto
Country [339] 0 0
Japan
State/province [339] 0 0
Kyoto
Country [340] 0 0
Japan
State/province [340] 0 0
Oita
Country [341] 0 0
Japan
State/province [341] 0 0
Osaka
Country [342] 0 0
Japan
State/province [342] 0 0
Shimane
Country [343] 0 0
Japan
State/province [343] 0 0
Tokyo
Country [344] 0 0
Korea, Republic of
State/province [344] 0 0
Bucheon-Si, Gyeonggi-Do
Country [345] 0 0
Korea, Republic of
State/province [345] 0 0
Bucheon
Country [346] 0 0
Korea, Republic of
State/province [346] 0 0
Busan
Country [347] 0 0
Korea, Republic of
State/province [347] 0 0
Cheonan
Country [348] 0 0
Korea, Republic of
State/province [348] 0 0
Chonju-si
Country [349] 0 0
Korea, Republic of
State/province [349] 0 0
Daegu
Country [350] 0 0
Korea, Republic of
State/province [350] 0 0
Daejeon
Country [351] 0 0
Korea, Republic of
State/province [351] 0 0
Goyang-si
Country [352] 0 0
Korea, Republic of
State/province [352] 0 0
Guri-si
Country [353] 0 0
Korea, Republic of
State/province [353] 0 0
Gwangju
Country [354] 0 0
Korea, Republic of
State/province [354] 0 0
Gyeonggi-do
Country [355] 0 0
Korea, Republic of
State/province [355] 0 0
Incheon
Country [356] 0 0
Korea, Republic of
State/province [356] 0 0
Kangwon
Country [357] 0 0
Korea, Republic of
State/province [357] 0 0
Seongnam
Country [358] 0 0
Korea, Republic of
State/province [358] 0 0
Seoul
Country [359] 0 0
Korea, Republic of
State/province [359] 0 0
Suwon, Gyeonggi-do
Country [360] 0 0
Korea, Republic of
State/province [360] 0 0
Uijeongbu, Gyeonggi-do
Country [361] 0 0
Korea, Republic of
State/province [361] 0 0
Ulsan
Country [362] 0 0
Korea, Republic of
State/province [362] 0 0
Wonju-si, Kanwon-do
Country [363] 0 0
Latvia
State/province [363] 0 0
Balvi
Country [364] 0 0
Latvia
State/province [364] 0 0
Daugavpils
Country [365] 0 0
Latvia
State/province [365] 0 0
Jekabpils
Country [366] 0 0
Latvia
State/province [366] 0 0
Jelgava
Country [367] 0 0
Latvia
State/province [367] 0 0
Jurmala
Country [368] 0 0
Latvia
State/province [368] 0 0
Kraslava
Country [369] 0 0
Latvia
State/province [369] 0 0
Kuldiga
Country [370] 0 0
Latvia
State/province [370] 0 0
Liepaja
Country [371] 0 0
Latvia
State/province [371] 0 0
Ogre
Country [372] 0 0
Latvia
State/province [372] 0 0
Riga
Country [373] 0 0
Latvia
State/province [373] 0 0
Talsi
Country [374] 0 0
Latvia
State/province [374] 0 0
Tukums
Country [375] 0 0
Latvia
State/province [375] 0 0
Valmiera
Country [376] 0 0
Latvia
State/province [376] 0 0
Ventspils
Country [377] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [377] 0 0
Bitola
Country [378] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [378] 0 0
Gostivar
Country [379] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [379] 0 0
Ohrid
Country [380] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [380] 0 0
Prilep
Country [381] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [381] 0 0
Shtip
Country [382] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [382] 0 0
Skopje
Country [383] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [383] 0 0
Strumica
Country [384] 0 0
Macedonia, The Former Yugoslav Republic of
State/province [384] 0 0
Veles
Country [385] 0 0
Malaysia
State/province [385] 0 0
Johor Bahru
Country [386] 0 0
Malaysia
State/province [386] 0 0
Kuala Lumpur
Country [387] 0 0
Malaysia
State/province [387] 0 0
Kuala Pilah
Country [388] 0 0
Malaysia
State/province [388] 0 0
Kuching
Country [389] 0 0
Malaysia
State/province [389] 0 0
Selangor
Country [390] 0 0
Malaysia
State/province [390] 0 0
Sibu
Country [391] 0 0
Malaysia
State/province [391] 0 0
Sungai Petani, Kedah
Country [392] 0 0
Malaysia
State/province [392] 0 0
Taiping Perak
Country [393] 0 0
Mexico
State/province [393] 0 0
Estado De México
Country [394] 0 0
Mexico
State/province [394] 0 0
Jalisco
Country [395] 0 0
Mexico
State/province [395] 0 0
Michoacán
Country [396] 0 0
Mexico
State/province [396] 0 0
Morelos
Country [397] 0 0
Mexico
State/province [397] 0 0
Nuevo León
Country [398] 0 0
Mexico
State/province [398] 0 0
Sonora
Country [399] 0 0
Mexico
State/province [399] 0 0
Aguascalientes
Country [400] 0 0
Mexico
State/province [400] 0 0
Chihuahua
Country [401] 0 0
Mexico
State/province [401] 0 0
Guadalajara
Country [402] 0 0
Mexico
State/province [402] 0 0
Hidalgo
Country [403] 0 0
Mexico
State/province [403] 0 0
Merida
Country [404] 0 0
Mexico
State/province [404] 0 0
Mexico D.F
Country [405] 0 0
Mexico
State/province [405] 0 0
Monterrey
Country [406] 0 0
Mexico
State/province [406] 0 0
México DF
Country [407] 0 0
Mexico
State/province [407] 0 0
San luis Potosí
Country [408] 0 0
Netherlands
State/province [408] 0 0
Alkmaar
Country [409] 0 0
Netherlands
State/province [409] 0 0
Almelo
Country [410] 0 0
Netherlands
State/province [410] 0 0
Ede Gld
Country [411] 0 0
Netherlands
State/province [411] 0 0
Helmond
Country [412] 0 0
Netherlands
State/province [412] 0 0
Zutphen
Country [413] 0 0
Philippines
State/province [413] 0 0
Alabang, Muntinlupa City
Country [414] 0 0
Philippines
State/province [414] 0 0
Caloocan
Country [415] 0 0
Philippines
State/province [415] 0 0
Cavite
Country [416] 0 0
Philippines
State/province [416] 0 0
Cebu City
Country [417] 0 0
Philippines
State/province [417] 0 0
Dasmariñas, Cavite
Country [418] 0 0
Philippines
State/province [418] 0 0
Davao
Country [419] 0 0
Philippines
State/province [419] 0 0
Iloilo City
Country [420] 0 0
Philippines
State/province [420] 0 0
Iloilo
Country [421] 0 0
Philippines
State/province [421] 0 0
Jaro, Iloilo City
Country [422] 0 0
Philippines
State/province [422] 0 0
Los Banos
Country [423] 0 0
Philippines
State/province [423] 0 0
Manila
Country [424] 0 0
Philippines
State/province [424] 0 0
Marilao, Bulacan
Country [425] 0 0
Philippines
State/province [425] 0 0
Pasay
Country [426] 0 0
Philippines
State/province [426] 0 0
Pasig
Country [427] 0 0
Philippines
State/province [427] 0 0
Quezon City
Country [428] 0 0
Philippines
State/province [428] 0 0
Quezon
Country [429] 0 0
Philippines
State/province [429] 0 0
San Fernando, Pampanga
Country [430] 0 0
Poland
State/province [430] 0 0
Bialystok
Country [431] 0 0
Poland
State/province [431] 0 0
Bielsko-Biala
Country [432] 0 0
Poland
State/province [432] 0 0
Bienkowka
Country [433] 0 0
Poland
State/province [433] 0 0
Bydgoszcz
Country [434] 0 0
Poland
State/province [434] 0 0
Chelmza
Country [435] 0 0
Poland
State/province [435] 0 0
Chodziez
Country [436] 0 0
Poland
State/province [436] 0 0
Chorzow
Country [437] 0 0
Poland
State/province [437] 0 0
Choszczno
Country [438] 0 0
Poland
State/province [438] 0 0
Czestochowa
Country [439] 0 0
Poland
State/province [439] 0 0
Dabrowa Gornicza
Country [440] 0 0
Poland
State/province [440] 0 0
Dzialdowo
Country [441] 0 0
Poland
State/province [441] 0 0
Elblag
Country [442] 0 0
Poland
State/province [442] 0 0
Gdansk
Country [443] 0 0
Poland
State/province [443] 0 0
Gdynia
Country [444] 0 0
Poland
State/province [444] 0 0
Gorzow Wielkopolski
Country [445] 0 0
Poland
State/province [445] 0 0
Grudziadz
Country [446] 0 0
Poland
State/province [446] 0 0
Ilawa
Country [447] 0 0
Poland
State/province [447] 0 0
Inowroclaw
Country [448] 0 0
Poland
State/province [448] 0 0
Izabelin
Country [449] 0 0
Poland
State/province [449] 0 0
Jelenia Gora
Country [450] 0 0
Poland
State/province [450] 0 0
Karpacz
Country [451] 0 0
Poland
State/province [451] 0 0
Katowice
Country [452] 0 0
Poland
State/province [452] 0 0
Kielce
Country [453] 0 0
Poland
State/province [453] 0 0
Krakow
Country [454] 0 0
Poland
State/province [454] 0 0
Krotoszyn
Country [455] 0 0
Poland
State/province [455] 0 0
Ksawerow
Country [456] 0 0
Poland
State/province [456] 0 0
Kutno
Country [457] 0 0
Poland
State/province [457] 0 0
Libiaz
Country [458] 0 0
Poland
State/province [458] 0 0
Lodz
Country [459] 0 0
Poland
State/province [459] 0 0
Lublin
Country [460] 0 0
Poland
State/province [460] 0 0
Olawa
Country [461] 0 0
Poland
State/province [461] 0 0
Olsztyn
Country [462] 0 0
Poland
State/province [462] 0 0
Ostrow Wilekopolski
Country [463] 0 0
Poland
State/province [463] 0 0
Ostrowiec Swietokrzyski
Country [464] 0 0
Poland
State/province [464] 0 0
Piaseczno
Country [465] 0 0
Poland
State/province [465] 0 0
Pila
Country [466] 0 0
Poland
State/province [466] 0 0
Plock
Country [467] 0 0
Poland
State/province [467] 0 0
Police
Country [468] 0 0
Poland
State/province [468] 0 0
Poznan
Country [469] 0 0
Poland
State/province [469] 0 0
Ruda Slaska
Country [470] 0 0
Poland
State/province [470] 0 0
Rudka
Country [471] 0 0
Poland
State/province [471] 0 0
Rzeszow
Country [472] 0 0
Poland
State/province [472] 0 0
Skarzysko-Kamienna
Country [473] 0 0
Poland
State/province [473] 0 0
Skierniewice
Country [474] 0 0
Poland
State/province [474] 0 0
Slupsk
Country [475] 0 0
Poland
State/province [475] 0 0
Sopot
Country [476] 0 0
Poland
State/province [476] 0 0
Swidnik
Country [477] 0 0
Poland
State/province [477] 0 0
Szczecin
Country [478] 0 0
Poland
State/province [478] 0 0
Tarnow
Country [479] 0 0
Poland
State/province [479] 0 0
Tczew
Country [480] 0 0
Poland
State/province [480] 0 0
Torun
Country [481] 0 0
Poland
State/province [481] 0 0
Warszawa
Country [482] 0 0
Poland
State/province [482] 0 0
Wloclawek
Country [483] 0 0
Poland
State/province [483] 0 0
Wloszczowa
Country [484] 0 0
Poland
State/province [484] 0 0
Wodzislaw Slaski
Country [485] 0 0
Poland
State/province [485] 0 0
Wroclaw
Country [486] 0 0
Poland
State/province [486] 0 0
Zabrze
Country [487] 0 0
Poland
State/province [487] 0 0
Zgierz
Country [488] 0 0
Poland
State/province [488] 0 0
Leczyca
Country [489] 0 0
Romania
State/province [489] 0 0
Arad
Country [490] 0 0
Romania
State/province [490] 0 0
Bacau
Country [491] 0 0
Romania
State/province [491] 0 0
Bragadiru
Country [492] 0 0
Romania
State/province [492] 0 0
Brasov
Country [493] 0 0
Romania
State/province [493] 0 0
Bucarest
Country [494] 0 0
Romania
State/province [494] 0 0
Bucharest
Country [495] 0 0
Romania
State/province [495] 0 0
Bucuresti
Country [496] 0 0
Romania
State/province [496] 0 0
Campulung Muscel
Country [497] 0 0
Romania
State/province [497] 0 0
Cluj-Napoca
Country [498] 0 0
Romania
State/province [498] 0 0
Codlea
Country [499] 0 0
Romania
State/province [499] 0 0
Constanta
Country [500] 0 0
Romania
State/province [500] 0 0
Deva
Country [501] 0 0
Romania
State/province [501] 0 0
Iasi
Country [502] 0 0
Romania
State/province [502] 0 0
Pitesti
Country [503] 0 0
Romania
State/province [503] 0 0
Ploiesti
Country [504] 0 0
Romania
State/province [504] 0 0
Ramnicu Valcea
Country [505] 0 0
Romania
State/province [505] 0 0
Suceava
Country [506] 0 0
Romania
State/province [506] 0 0
Targu-Mures
Country [507] 0 0
Romania
State/province [507] 0 0
Timisoara
Country [508] 0 0
Russian Federation
State/province [508] 0 0
Arkhangelsk
Country [509] 0 0
Russian Federation
State/province [509] 0 0
Barnaul
Country [510] 0 0
Russian Federation
State/province [510] 0 0
Chelyabinsk
Country [511] 0 0
Russian Federation
State/province [511] 0 0
Ekaterinburg
Country [512] 0 0
Russian Federation
State/province [512] 0 0
Gatchina
Country [513] 0 0
Russian Federation
State/province [513] 0 0
Ivanovo
Country [514] 0 0
Russian Federation
State/province [514] 0 0
Izhevsk
Country [515] 0 0
Russian Federation
State/province [515] 0 0
Kaliningrad
Country [516] 0 0
Russian Federation
State/province [516] 0 0
Kazan
Country [517] 0 0
Russian Federation
State/province [517] 0 0
Kemerovo
Country [518] 0 0
Russian Federation
State/province [518] 0 0
Kirov
Country [519] 0 0
Russian Federation
State/province [519] 0 0
Krasnoyarsk
Country [520] 0 0
Russian Federation
State/province [520] 0 0
Kursk
Country [521] 0 0
Russian Federation
State/province [521] 0 0
Moscow
Country [522] 0 0
Russian Federation
State/province [522] 0 0
Nizhniy Novgorod
Country [523] 0 0
Russian Federation
State/province [523] 0 0
Novosibirsk
Country [524] 0 0
Russian Federation
State/province [524] 0 0
Orenburg
Country [525] 0 0
Russian Federation
State/province [525] 0 0
Perm
Country [526] 0 0
Russian Federation
State/province [526] 0 0
Pskov
Country [527] 0 0
Russian Federation
State/province [527] 0 0
Rostov-on-Don
Country [528] 0 0
Russian Federation
State/province [528] 0 0
Ryazan
Country [529] 0 0
Russian Federation
State/province [529] 0 0
Saint Petersburg
Country [530] 0 0
Russian Federation
State/province [530] 0 0
Saint-Petersburg
Country [531] 0 0
Russian Federation
State/province [531] 0 0
Saratov
Country [532] 0 0
Russian Federation
State/province [532] 0 0
Sestroretsk
Country [533] 0 0
Russian Federation
State/province [533] 0 0
Smolensk
Country [534] 0 0
Russian Federation
State/province [534] 0 0
St Petersburg
Country [535] 0 0
Russian Federation
State/province [535] 0 0
St'Petersburg
Country [536] 0 0
Russian Federation
State/province [536] 0 0
St-Petersburg
Country [537] 0 0
Russian Federation
State/province [537] 0 0
St. Petersburg
Country [538] 0 0
Russian Federation
State/province [538] 0 0
St.Petersburg
Country [539] 0 0
Russian Federation
State/province [539] 0 0
St.?etersburg
Country [540] 0 0
Russian Federation
State/province [540] 0 0
Tomsk
Country [541] 0 0
Russian Federation
State/province [541] 0 0
Tver
Country [542] 0 0
Russian Federation
State/province [542] 0 0
Ufa
Country [543] 0 0
Russian Federation
State/province [543] 0 0
Ulyanovsk
Country [544] 0 0
Russian Federation
State/province [544] 0 0
Voronezh
Country [545] 0 0
Russian Federation
State/province [545] 0 0
Vsevolzhsk
Country [546] 0 0
Russian Federation
State/province [546] 0 0
Yaroslavl
Country [547] 0 0
Serbia
State/province [547] 0 0
Belgrade
Country [548] 0 0
Serbia
State/province [548] 0 0
Cacak
Country [549] 0 0
Serbia
State/province [549] 0 0
Kragujevac
Country [550] 0 0
Serbia
State/province [550] 0 0
Nis
Country [551] 0 0
Serbia
State/province [551] 0 0
Sombor
Country [552] 0 0
Serbia
State/province [552] 0 0
Sremska Kamenica
Country [553] 0 0
Serbia
State/province [553] 0 0
Valjevo
Country [554] 0 0
Slovakia
State/province [554] 0 0
Bratislava
Country [555] 0 0
Slovakia
State/province [555] 0 0
Kosice
Country [556] 0 0
Slovakia
State/province [556] 0 0
Kralovsky Chlmec
Country [557] 0 0
Slovakia
State/province [557] 0 0
Nove Zamky
Country [558] 0 0
Slovakia
State/province [558] 0 0
Presov
Country [559] 0 0
Slovakia
State/province [559] 0 0
Spisska Nova Ves
Country [560] 0 0
Slovakia
State/province [560] 0 0
Sturovo
Country [561] 0 0
Slovakia
State/province [561] 0 0
Trnava
Country [562] 0 0
Slovakia
State/province [562] 0 0
Vrable
Country [563] 0 0
South Africa
State/province [563] 0 0
Gauteng
Country [564] 0 0
South Africa
State/province [564] 0 0
KwaZulu- Natal
Country [565] 0 0
South Africa
State/province [565] 0 0
Mpumalanga
Country [566] 0 0
South Africa
State/province [566] 0 0
Benoni
Country [567] 0 0
South Africa
State/province [567] 0 0
Bloemfontein
Country [568] 0 0
South Africa
State/province [568] 0 0
Cape Town
Country [569] 0 0
South Africa
State/province [569] 0 0
CapeTown
Country [570] 0 0
South Africa
State/province [570] 0 0
Durban
Country [571] 0 0
South Africa
State/province [571] 0 0
Gatesville
Country [572] 0 0
South Africa
State/province [572] 0 0
Johannesburg
Country [573] 0 0
South Africa
State/province [573] 0 0
Korsten
Country [574] 0 0
South Africa
State/province [574] 0 0
Lynnwood Ridge
Country [575] 0 0
South Africa
State/province [575] 0 0
Mowbray
Country [576] 0 0
South Africa
State/province [576] 0 0
Paarl
Country [577] 0 0
South Africa
State/province [577] 0 0
Panorama
Country [578] 0 0
South Africa
State/province [578] 0 0
Potchefstroom
Country [579] 0 0
South Africa
State/province [579] 0 0
Pretoria
Country [580] 0 0
South Africa
State/province [580] 0 0
Roodepoort
Country [581] 0 0
South Africa
State/province [581] 0 0
Rooihuiskraal
Country [582] 0 0
South Africa
State/province [582] 0 0
Somerset West
Country [583] 0 0
South Africa
State/province [583] 0 0
Thabazimbi
Country [584] 0 0
South Africa
State/province [584] 0 0
Tygerberg
Country [585] 0 0
South Africa
State/province [585] 0 0
Voorspoed
Country [586] 0 0
Spain
State/province [586] 0 0
Badalona
Country [587] 0 0
Spain
State/province [587] 0 0
Barcelona
Country [588] 0 0
Spain
State/province [588] 0 0
Benidorm
Country [589] 0 0
Spain
State/province [589] 0 0
Canet De Mar - Barcelona
Country [590] 0 0
Spain
State/province [590] 0 0
Galdakano
Country [591] 0 0
Spain
State/province [591] 0 0
Illescas-Toledo
Country [592] 0 0
Spain
State/province [592] 0 0
Jerez de la Frontera
Country [593] 0 0
Spain
State/province [593] 0 0
L'Hospitalet de Llobregat
Country [594] 0 0
Spain
State/province [594] 0 0
Madrid
Country [595] 0 0
Spain
State/province [595] 0 0
Mataró
Country [596] 0 0
Spain
State/province [596] 0 0
Oviedo
Country [597] 0 0
Spain
State/province [597] 0 0
Palma de Mallorca
Country [598] 0 0
Spain
State/province [598] 0 0
Pamplona
Country [599] 0 0
Spain
State/province [599] 0 0
Pozuelo De Alarcón/Madrid
Country [600] 0 0
Spain
State/province [600] 0 0
Sabadell (Barcelona)
Country [601] 0 0
Spain
State/province [601] 0 0
Sagunto/Valencia
Country [602] 0 0
Spain
State/province [602] 0 0
Sant Boi de Llobregat
Country [603] 0 0
Spain
State/province [603] 0 0
Santa Coloma de Gramenet
Country [604] 0 0
Spain
State/province [604] 0 0
Santiago de Compostela
Country [605] 0 0
Spain
State/province [605] 0 0
Torrelavega
Country [606] 0 0
Spain
State/province [606] 0 0
Valencia
Country [607] 0 0
Spain
State/province [607] 0 0
Vic (Barcelona)
Country [608] 0 0
Taiwan
State/province [608] 0 0
Changhua
Country [609] 0 0
Taiwan
State/province [609] 0 0
Chia-Yi
Country [610] 0 0
Taiwan
State/province [610] 0 0
Kaohsiung Hsien
Country [611] 0 0
Taiwan
State/province [611] 0 0
Kaohsiung
Country [612] 0 0
Taiwan
State/province [612] 0 0
Keelung
Country [613] 0 0
Taiwan
State/province [613] 0 0
LinKou
Country [614] 0 0
Taiwan
State/province [614] 0 0
Taichung
Country [615] 0 0
Taiwan
State/province [615] 0 0
Tainan
Country [616] 0 0
Taiwan
State/province [616] 0 0
Taipei
Country [617] 0 0
Taiwan
State/province [617] 0 0
Yung Kang City
Country [618] 0 0
Thailand
State/province [618] 0 0
Bangkok
Country [619] 0 0
Thailand
State/province [619] 0 0
Chiangmai
Country [620] 0 0
Thailand
State/province [620] 0 0
Chiangrai
Country [621] 0 0
Thailand
State/province [621] 0 0
Khon Kaen
Country [622] 0 0
Thailand
State/province [622] 0 0
Mae Rim, Chiang Mai
Country [623] 0 0
Thailand
State/province [623] 0 0
Muang Phitsanulok
Country [624] 0 0
Thailand
State/province [624] 0 0
Muang
Country [625] 0 0
Thailand
State/province [625] 0 0
Nakhon Ratchasima
Country [626] 0 0
Thailand
State/province [626] 0 0
Phitsanulok
Country [627] 0 0
Thailand
State/province [627] 0 0
Songkla
Country [628] 0 0
Turkey
State/province [628] 0 0
Ankara
Country [629] 0 0
Turkey
State/province [629] 0 0
Bursa
Country [630] 0 0
Turkey
State/province [630] 0 0
Istanbul
Country [631] 0 0
Turkey
State/province [631] 0 0
Kocaeli
Country [632] 0 0
Turkey
State/province [632] 0 0
Konya
Country [633] 0 0
Turkey
State/province [633] 0 0
Samsun
Country [634] 0 0
Ukraine
State/province [634] 0 0
Alupka
Country [635] 0 0
Ukraine
State/province [635] 0 0
Cherkassy
Country [636] 0 0
Ukraine
State/province [636] 0 0
Chernihiv
Country [637] 0 0
Ukraine
State/province [637] 0 0
Chernivtsi
Country [638] 0 0
Ukraine
State/province [638] 0 0
Dnipropetrovsk
Country [639] 0 0
Ukraine
State/province [639] 0 0
Donetsk
Country [640] 0 0
Ukraine
State/province [640] 0 0
Ivano-Frankivsk
Country [641] 0 0
Ukraine
State/province [641] 0 0
Kharkiv
Country [642] 0 0
Ukraine
State/province [642] 0 0
Kherson
Country [643] 0 0
Ukraine
State/province [643] 0 0
Kiev
Country [644] 0 0
Ukraine
State/province [644] 0 0
Kryvyi Rig
Country [645] 0 0
Ukraine
State/province [645] 0 0
Kyiv
Country [646] 0 0
Ukraine
State/province [646] 0 0
Lutsk
Country [647] 0 0
Ukraine
State/province [647] 0 0
Lviv
Country [648] 0 0
Ukraine
State/province [648] 0 0
Mykolaiv
Country [649] 0 0
Ukraine
State/province [649] 0 0
Odesa
Country [650] 0 0
Ukraine
State/province [650] 0 0
Odessa
Country [651] 0 0
Ukraine
State/province [651] 0 0
Poltava
Country [652] 0 0
Ukraine
State/province [652] 0 0
Simferopol
Country [653] 0 0
Ukraine
State/province [653] 0 0
Sumy
Country [654] 0 0
Ukraine
State/province [654] 0 0
Sympheropol
Country [655] 0 0
Ukraine
State/province [655] 0 0
Ternopil
Country [656] 0 0
Ukraine
State/province [656] 0 0
Uzhhorod
Country [657] 0 0
Ukraine
State/province [657] 0 0
Vinnytsia
Country [658] 0 0
Ukraine
State/province [658] 0 0
Vinnytsya
Country [659] 0 0
Ukraine
State/province [659] 0 0
Yalta
Country [660] 0 0
Ukraine
State/province [660] 0 0
Zaporizhia
Country [661] 0 0
Ukraine
State/province [661] 0 0
Zaporizhzhia
Country [662] 0 0
Ukraine
State/province [662] 0 0
Zaporizhzhya
Country [663] 0 0
Ukraine
State/province [663] 0 0
Zhytomyr
Country [664] 0 0
United Kingdom
State/province [664] 0 0
Bedfordshire
Country [665] 0 0
United Kingdom
State/province [665] 0 0
Cambridgeshire
Country [666] 0 0
United Kingdom
State/province [666] 0 0
Derbyshire
Country [667] 0 0
United Kingdom
State/province [667] 0 0
Lancashire
Country [668] 0 0
United Kingdom
State/province [668] 0 0
Merseyside
Country [669] 0 0
United Kingdom
State/province [669] 0 0
Middlesex
Country [670] 0 0
United Kingdom
State/province [670] 0 0
Suffolk
Country [671] 0 0
United Kingdom
State/province [671] 0 0
Bexhill-on-Sea
Country [672] 0 0
United Kingdom
State/province [672] 0 0
Birmingham
Country [673] 0 0
United Kingdom
State/province [673] 0 0
Brighton
Country [674] 0 0
United Kingdom
State/province [674] 0 0
Cardiff
Country [675] 0 0
United Kingdom
State/province [675] 0 0
Chelmsford
Country [676] 0 0
United Kingdom
State/province [676] 0 0
Derby
Country [677] 0 0
United Kingdom
State/province [677] 0 0
Edgbaston, Birmingham
Country [678] 0 0
United Kingdom
State/province [678] 0 0
Edinburgh
Country [679] 0 0
United Kingdom
State/province [679] 0 0
Glasgow
Country [680] 0 0
United Kingdom
State/province [680] 0 0
London
Country [681] 0 0
United Kingdom
State/province [681] 0 0
Manchester
Country [682] 0 0
United Kingdom
State/province [682] 0 0
Milton Keynes
Country [683] 0 0
United Kingdom
State/province [683] 0 0
Reading
Country [684] 0 0
United Kingdom
State/province [684] 0 0
Sidcup, Kent
Country [685] 0 0
United Kingdom
State/province [685] 0 0
Tyne And Wear
Country [686] 0 0
Vietnam
State/province [686] 0 0
Can Tho
Country [687] 0 0
Vietnam
State/province [687] 0 0
Ha Noi
Country [688] 0 0
Vietnam
State/province [688] 0 0
Ho Chi Minh
Country [689] 0 0
Vietnam
State/province [689] 0 0
Hue

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
GlaxoSmithKline
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
GSK Clinical Trials
Address 0 0
GlaxoSmithKline
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

No information has been provided regarding IPD availability


What supporting documents are/will be available?

No Supporting Document Provided



Results publications and other study-related documents

No documents have been uploaded by study researchers.