Trial Review

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Trial registered on ANZCTR


Registration number
Help: Registration number
ACTRN12626001271392
Ethics application status
Help: Ethics application status
Approved
Date submitted
Help: Date submitted
28/09/2026
Date registered
Help: Date registered
23/10/2026
Date last updated
Help: Date last updated
23/10/2026
Date data sharing statement initially provided
Help: Data sharing statement date
23/10/2026
Type of registration
Help: Type of registration
Prospectively registered

Titles & IDs
Public title
The effect of kiwifruit on meat digestion using fecal samples donated by generally healthy individuals
Scientific title
The effect of kiwifruit on meat protein digestion and gut fermentation using fecal samples donated by generally healthy individuals
Additional trial identifiers [1] 318539 0
Nil
Universal Trial Number (UTN)
U1111-1345-1785
Trial acronym
IVR_PV1
Related trial records

Health condition
Health condition(s) studied:
Poor protein digestion 343734 0
Condition category
Condition code
Oral and Gastrointestinal 339853 339853 0 0
Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
Diet and Nutrition 339854 339854 0 0
Other diet and nutrition disorders

Intervention/exposure
Study type
Observational
Patient registry
False
Target follow-up duration
Target follow-up type
Description of the intervention or exposure
The study is being completed as protein digestibility declines with age. However, at this stage of the research we are using one-off fecal donations from generally healthy donors between 18 and 65 years. Participants will fill out a brief health questionnaire to access their eligibility to participate in the study, Eligible participants will be provided with a fecal collection kit and be asked to donate a one-off fecal sample. On receipt the fecal sample will be processed into a fecal slurry within 4 hours of collection. The fecal sample will be exposed to different kiwifruit varieties (Hayward, HiHi, RubyRed) with a mix of meat proteins including chicken, pork and lamb, each kiwifruit variety with no meat protein, meat protein with no kiwifruit and no treatment controls. Following treatment the fecal samples will be left to ferment up to 24 hours. Sub-samples will be taken for analysis through-out the fermentation process.
Intervention code [1] 335442 0
Not applicable
Description of the comparator or control
Controls with meat protein and no kiwifruit will serve as the main comparator, Kiwifruit with no meat and no treatment will serve as additional controls.
Control group
Active

Outcomes
Primary outcome [1] 347030 0
Protein putrefaction products (phenolic compounds and indolic compounds) will be assessed as a composite primary outcome
Timepoint [1] 347030 0
0, 12 and 24 hours post-sample treatment.
Primary outcome [2] 347235 0
ammonia
Timepoint [2] 347235 0
0, 12 and 24 hours post-sample treatment.
Secondary outcome [1] 468628 0
Short-chain fatty acids (SCFA) including acetate, butyrate, propionate, lactate, succinate, heptanoate, isobutyrate, formate, isovalerate, valerate and hexanoate will be assessed as a composite secondary outcome
Timepoint [1] 468628 0
0, 12 and 24 hours post-sample treatment.

Eligibility
Key inclusion criteria
Be a healthy adult
Be aged 18-65 years
Be able to comply with study procedures
Be able to provide written consent
Minimum age
18 Years
Maximum age
65 Years
Sex
Both males and females
Healthy volunteers
Yes
Key exclusion criteria
Are taking medication that affects the properties of your faecal sample e.g. laxatives or antibiotics
Smoke or vape
Have any long-term chronic illnesses (e.g. cancer)
Are pregnant, breastfeeding, or planning to be pregnant in the near future
Are taking part in another study at the same time
Have any gastrointestinal disorders (e.g. IBS or IBD)

Study design
Purpose
Duration
Selection
Timing
Statistical methods / analysis

Recruitment
Recruitment status
Not yet recruiting
Date of first participant enrolment
Anticipated
2/11/2026
Actual
Date of last participant enrolment
Anticipated
2/11/2026
Actual
Date of last data collection
Anticipated
3/11/2026
Actual
Sample size
Target
10
Accrual to date
Final
Recruitment outside Australia
Country [1] 28605 0
New Zealand
State/province [1] 28605 0

Funding & Sponsors
Funding source category [1] 323120 0
Government body
Name [1] 323120 0
New Zealand Institute for Bioeconomy Science Limited
Country [1] 323120 0
New Zealand
Primary sponsor type
Government body
Name
New Zealand Institute for Bioeconomy Science Limited
Address
Country
New Zealand
Secondary sponsor category [1] 326073 0
None
Name [1] 326073 0
Address [1] 326073 0
Country [1] 326073 0

Ethics approval
Ethics application status
Approved
Ethics committee name [1] 321520 0
Northern B Health and Disability Ethics Committee 
Ethics committee address [1] 321520 0
Ethics committee country [1] 321520 0
New Zealand
Date submitted for ethics approval [1] 321520 0
02/10/2026
Approval date [1] 321520 0
15/10/2026
Ethics approval number [1] 321520 0
2026 EXP 26808

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 153966 0
Dr Kerry Bentley-Hewitt
Address 153966 0
New Zealand Institute for Bioeconomy Science Limited, Private Bag 11600, Palmerston North 4442
Country 153966 0
New Zealand
Phone 153966 0
+64 6 3556215
Fax 153966 0
Email 153966 0
[email protected]
Contact person for public queries
Name 153967 0
Kerry Bentley-Hewitt
Address 153967 0
New Zealand Institute for Bioeconomy Science Limited, Private Bag 11600, Palmerston North 4442
Country 153967 0
New Zealand
Phone 153967 0
+64 6 3556215
Fax 153967 0
Email 153967 0
[email protected]
Contact person for scientific queries
Name 153968 0
Kerry Bentley-Hewitt
Address 153968 0
New Zealand Institute for Bioeconomy Science Limited, Private Bag 11600, Palmerston North 4442
Country 153968 0
New Zealand
Phone 153968 0
+6463556215
Fax 153968 0
Email 153968 0
[email protected]

Data sharing statement
Will the study consider sharing individual participant data?
No


What supporting documents are/will be available?



Results publications and other study-related documents

Documents added manually
No documents have been uploaded by study researchers.

Documents added automatically
No additional documents have been identified.