COVID-19 studies are our top priority.

For new and updated trial submissions, we are processing trials as quickly as possible and appreciate your patience. We recommend submitting your trial for registration at the same time as ethics submission.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
Use of Fish Oils to Reduce Recurrence of Atrial Fibrillation Following DC Cardioversion
Scientific title
Use of Fish Oils to Reduce Recurrence of Atrial Fibrillation Following DC Cardioversion.
Secondary ID [1] 0 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Atrial Fibrillation 0 0
Condition category
Condition code
Cardiovascular 0 0 0 0
Other cardiovascular diseases
Other 0 0 0 0
Research that is not of generic health relevance and not applicable to specific health categories listed above

Study type
Description of intervention(s) / exposure
Treatment: Drugs - Fish oil

No Intervention: Control - No fish oil exposure

Experimental: Fish oil - Patients given 6g/day of fish oil containing 1.8g/d of EPA+DHA in a 1.5:1 ratio.

Treatment: Drugs: Fish oil

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Primary outcome [1] 0 0
Recurrence of atrial fibrillation followed cardioversion
Timepoint [1] 0 0
1 year

Key inclusion criteria
- Patients with persistent Atrial Fibrillation on Warfarin.
Minimum age
18 Years
Maximum age
80 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- paroxysmal atrial fibrillation with self terminating episodes.

- left atrial size>6.0cm

- myocardial infarction in the previous 6 months.

- contraindications to amiodarone use .

- cardiac surgery in the previous 3 months .

- an acute reversible illness contributing to the development of af

- a QTc interval > 480ms.

- pregnancy

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Phase 4
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
Royal Melbourne hospital - Melbourne
Recruitment postcode(s) [1] 0 0
3050 - Melbourne

Funding & Sponsors
Primary sponsor type
Melbourne Health

Ethics approval
Ethics application status

Brief summary
The purpose of this study is to investigate whether fish oil supplements may be beneficial in
preventing the recurrence of atrial fibrillation after cardioversion.

Atrial fibrillation is a heart condition which can sometimes be successfully treated by a

Cardioversion involves resetting the heart back to normal with the use of electric current.

There is a tendency for the atrial fibrillation to recur , days weeks or even months after
the cardioversion.

Fish oil supplements may be of benefit to patients with heart problems Recent evidence
suggests that fish oils may be beneficial to patients with rhythm disturbances.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 0 0
Paul Sparks, MBBS, PhD. FRACP
Address 0 0
Melbourne Health
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Summary results
Other publications