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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Retrospectively registered

Titles & IDs
Public title
A trial of Cognitive Behavioural Therapy with adult clients diagnosed with Asperger's Disorder, to treat anxiety and depression
Scientific title
A trial of Cognitive Behavioural Therapy with adult clients diagnosed with Asperger's Disorder, to treat anxiety and depression
Secondary ID [1] 283694 0
Nil known
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
anxiety 4790 0
depression 4791 0
asperger's disorder 4792 0
Condition category
Condition code
Mental Health 5030 5030 0 0
Autistic spectrum disorders
Mental Health 237134 237134 0 0
Mental Health 237135 237135 0 0

Study type
Description of intervention(s) / exposure
12 individual 50 minute sessions per client, held once per week for a total of 12 weeks, using Cognitive Behavioural Therapy approaches including psycho education, relaxation training, and correction of maladaptive cognitions.
Intervention code [1] 4477 0
Intervention code [2] 4564 0
Other interventions
Comparator / control treatment
Multiple baseline design, tracking anxiety and depression self reports using patient questionnaires, before, during and after initiation of treatment
Control group

Primary outcome [1] 5869 0
Depression Anxiety Stress Scales (Lovibond and Lovibond, 2004)
Timepoint [1] 5869 0
weekly for 15 weeks (including before and after treatment sessions)
Primary outcome [2] 237955 0
anxiety and depression score self reports
Timepoint [2] 237955 0
three tims daily for 15 weeks (including before and after treatment sessions)
Secondary outcome [1] 242053 0
client reports on progress
Timepoint [1] 242053 0
weekly for 12 weeks during treatment period

Key inclusion criteria
Over 18
diagnosed with Asperger's Disorder
Minimum age
18 Years
Maximum age
No limit
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
not able to evidence diagnosis,
comorbid conditions / complexities making it apparent a short term intervention is inappropriate
not self referred
prviously known to researcher

Study design
Purpose of the study
Allocation to intervention
Non-randomised trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?

Intervention assignment
Other design features
multiple baseline design; 8 clients starting in staggered weeks
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)

Funding & Sponsors
Funding source category [1] 4887 0
Self funded/Unfunded
Name [1] 4887 0
Address [1] 4887 0
Country [1] 4887 0
Primary sponsor type
University of South Australia
GPO Box 2471
South Australia 5001
Secondary sponsor category [1] 4421 0
Name [1] 4421 0
Address [1] 4421 0
Country [1] 4421 0

Ethics approval
Ethics application status
Ethics committee name [1] 6952 0
University of SA Human Research Ethics Committee
Ethics committee address [1] 6952 0
University of South Australia
GPO Box 2471
South Australia 5001
Ethics committee country [1] 6952 0
Date submitted for ethics approval [1] 6952 0
Approval date [1] 6952 0
Ethics approval number [1] 6952 0

Brief summary
To evaluate use of cognitive behavioural therapy to treat anxiety and depression in clients with Asperger's Disorder
Trial website
Trial related presentations / publications
The study has been completed and submitted as part of requirements for the degree of Doctor of Psychology (Clinical) at the University of SA. The following is the abstract of the thesis:
A program was provided to seven adult clients previously diagnosed with Asperger’s disorder (AsD) who responded to a letter offering a program using cognitive behavioural therapy (CBT) approaches to clients with AsD who also experienced difficulty with anxiety, depression, or handling social situations. Four clients presented with clinically significant levels of depression and/or anxiety. For three of these, Depression Anxiety Stress Scales (DASS) questionnaire results indicated positive clinically significant change. The fourth client showed some desired changes in behaviour. Three clients presented with sub-clinical levels of anxiety and depression prior to treatment. While there were some decreases in DASS scores for these clients, they were not clinically significant. All clients reported they found the program helpful and that they had learned and implemented skills found helpful in their daily lives. Psycho-education, behavioural skills like progressive relaxation and an impulse control strategy called 'Stop 1, 2, 3, Cool it Breathing,' (S123CIB) and cognitive strategies such as identifying and then challenging thoughts identified as leading to feelings expressed through inappropriate actions were found helpful. The findings of this report are encouraging and supportive of use of CBT with clients with AsD, although the small numbers involved mean that findings are tentative, and suggestive of areas of further research rather than conclusive.
Public notes

Principal investigator
Name 29561 0
Dr Piet Crosby
Address 29561 0
PO 3144
Melbourne St
North Adelaide 5006
South Australia
Country 29561 0
Phone 29561 0
Fax 29561 0
Email 29561 0
Contact person for public queries
Name 12808 0
Dr Piet Crosby
Address 12808 0
PO 3144 Melbourne St
North Adelaide
South Australia 5006
Country 12808 0
Phone 12808 0
+61 417706145
Fax 12808 0
Email 12808 0
Contact person for scientific queries
Name 3736 0
Dr Piet Crosby
Address 3736 0
PO 3144 Melbourne St
North Adelaide
South Australia 5006
Country 3736 0
Phone 3736 0
+61 417706145
Fax 3736 0
Email 3736 0

No information has been provided regarding IPD availability
Summary results
Have study results been published in a peer-reviewed journal?
Other publications
Have study results been made publicly available in another format?
Results – basic reporting
Results – plain English summary