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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Retrospectively registered

Titles & IDs
Public title
Pain Relief after Hip Replacement Surgery: A comparison of two approaches
Scientific title
Optimising Pain Relief after Hip Replacement Surgery: A comparison of Patient Controlled Lumbar Plexus Block and Patient Controlled Iintravenous (IV) Opioid Analgesia
Secondary ID [1] 259925 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Pain relief after hip replacement surgery 4532 0
Condition category
Condition code
Anaesthesiology 4820 4820 0 0
Other anaesthesiology

Study type
Description of intervention(s) / exposure
Patient controlled continuous lumbar plexus block (ropivacaine 0.2% 5 ml/hr with as required 5 ml boluses via a catheter inserted near the lumbar plexus) during the first 48 postoperative hours after hip replacement surgery
Intervention code [1] 4291 0
Treatment: Drugs
Comparator / control treatment
Subarachnoid block (bupivacaine 0.5% 2.5 mL) with Patient controlled intravenous opioid (morphine) analgesia during the first 48 postoperative hours after hip replacement surgery
Control group

Primary outcome [1] 5680 0
Pain after hip replacement surgery, assessed by patient interrogation regarding analgesic consumption pain scores using numerical rating pain score (NRPS).
Timepoint [1] 5680 0
1-2 days postoperatively. Analgesic requirements and pain scores measured in the afternoon of Day 1 and Day 2 following surgery.
Secondary outcome [1] 241579 0
Postoperative antiemetic consumption
Timepoint [1] 241579 0
First 48 postoperative hours every 24 hours.
Secondary outcome [2] 241979 0
Procedural time
Timepoint [2] 241979 0
At time of procedure
Secondary outcome [3] 241980 0
Patient physiotherapy endpoints:
Bed-to-chair: yes/no
Bed-to-bathroom: yes/no
Walk > 12 metres: yes/no
Timepoint [3] 241980 0
Daily for first 2 days

Key inclusion criteria
Patients requiring analgesia following hip replacement surgery under the care of the three investigators
Minimum age
No limit
Maximum age
No limit
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
1. Patient refusal of either block. 2. Known neuropathy involving the leg undergoing surgery. 3. Known allergy to amide local anaesthetic drugs.

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Initial invitation to participate in the study will occur in the surgeon's rooms. Approximately one week prior to surgery, patients will be contacted by a research assistant to provide further informed consent. Written informed consent will be obtained from all patients.
Assignment of the patient to lumbar plexus block or IV opioid analgesia will be delivered in a sealed opaque envelope.
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
A computerised random number generator will be used to assign the patient to one of the 2 groups.
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Active, not recruiting
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment outside Australia
Country [1] 1700 0
New Zealand
State/province [1] 1700 0

Funding & Sponsors
Funding source category [1] 4722 0
Name [1] 4722 0
Auckland Medical Research Foundation
Address [1] 4722 0
P O Box 110139 Auckland Hospital Auckland 1148
Country [1] 4722 0
New Zealand
Primary sponsor type
Dr Michael Fredrickson
Anaesthesia Institute,
P O Box 109 199,
Auckland 1149
New Zealand
Secondary sponsor category [1] 4267 0
Name [1] 4267 0
Address [1] 4267 0
Country [1] 4267 0

Ethics approval
Ethics application status
Ethics committee name [1] 6765 0
Northern Y Regional Ethics Committee
Ethics committee address [1] 6765 0
P O Box 1031,
Waikato Mail Centre 3240
Ethics committee country [1] 6765 0
New Zealand
Date submitted for ethics approval [1] 6765 0
Approval date [1] 6765 0
Ethics approval number [1] 6765 0

Brief summary
If the primary hypothesis is confirmed, this study will provide evidence supporting the Patient Controlled Lumbar Plexus Block for postoperative analgesia for total hip replacement surgery. Increased exposure of the techniques may promote their uptake in this setting.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 29440 0
Dr Michael Fredrickson
Address 29440 0
Anaesthesia Institute
P O Box 109 199
Auckland 1050
Country 29440 0
New Zealand
Phone 29440 0
Fax 29440 0
Email 29440 0
Contact person for public queries
Name 12687 0
Dr Dr Michael Fredrickson
Address 12687 0
Anaesthesia Institute
P O Box 109 199
Auckland 1149
Country 12687 0
New Zealand
Phone 12687 0
+64 9 522 1117
Fax 12687 0
+64 9 522 1127
Email 12687 0
Contact person for scientific queries
Name 3615 0
Dr Dr Michael Fredrickson
Address 3615 0
Anaesthesia Institute
P O Box 109 199
Auckland 1149
Country 3615 0
New Zealand
Phone 3615 0
+64 9 522 1117
Fax 3615 0
+64 9 522 1127
Email 3615 0

No information has been provided regarding IPD availability
Summary results
Have study results been published in a peer-reviewed journal?
Other publications
Have study results been made publicly available in another format?
Results – basic reporting
Results – plain English summary