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Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
Comparison of Glue With Sutures for Pterygium Surgery
Scientific title
Comparison of Cut and Paste With Sutured Autograft Pterygium Excision
Secondary ID [1] 0 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Pterygium 0 0
Condition category
Condition code
Eye 0 0 0 0
Diseases / disorders of the eye

Study type
Description of intervention(s) / exposure
Treatment: Surgery - Pterygium excision and conjunctival autograft

Treatment: Surgery: Pterygium excision and conjunctival autograft

Intervention code [1] 0 0
Treatment: Surgery
Comparator / control treatment
Control group

Primary outcome [1] 0 0
Surgery time
Timepoint [1] 0 0
Primary outcome [2] 0 0
Patient discomfort at day one, week one, two, four
Timepoint [2] 0 0
Primary outcome [3] 0 0
Recurrence rate at months three, six, twelve
Timepoint [3] 0 0

Key inclusion criteria
- Primary pterygium
Minimum age
20 Years
Maximum age
No limit
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- Ocular surface disease

- Previous pterygium surgery

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Unknown status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment outside Australia
Country [1] 0 0
New Zealand
State/province [1] 0 0

Funding & Sponsors
Primary sponsor type
Wellington Hospital
Other collaborator category [1] 0 0
Commercial sector/Industry
Name [1] 0 0
Baxter Healthcare Corporation
Address [1] 0 0
Country [1] 0 0

Ethics approval
Ethics application status

Brief summary
Pterygium excision surgery involves excising the abnormal growth from the cornea and filling
the defect with a conjunctival (white of the eye) graft from the superior part of the eye.
This is the best method of pterygium excision but it is recognised that in 10-15% of cases it
will grow back (recurrence). Currently the investigators use small sutures to sew the graft
in place. Recently it has been described that glue can be used instead of the sutures. It has
been shown in one study that the patient discomfort is less and so is the surgical time. The
investigators want to confirm these findings and also compare the recurrence rate between the
two types of surgery. They plan to complete a prospective, randomised, control trial of 40
participants. Twenty will have traditional pterygium surgery with the conjunctival autograft
sutured. Twenty will have cut and paste surgery with Tisseel glue. The two groups of
participants will be compared for pain and discomfort, surgery time, and recurrence rate of
the pterygia.
Trial website
Trial related presentations / publications
Koranyi G, Seregard S, Kopp ED. The cut-and-paste method for primary pterygium surgery: long-term follow-up. Acta Ophthalmol Scand. 2005 Jun;83(3):298-301.
Uy HS, Reyes JM, Flores JD, Lim-Bon-Siong R. Comparison of fibrin glue and sutures for attaching conjunctival autografts after pterygium excision. Ophthalmology. 2005 Apr;112(4):667-71.
Koranyi G, Seregard S, Kopp ED. Cut and paste: a no suture, small incision approach to pterygium surgery. Br J Ophthalmol. 2004 Jul;88(7):911-4.
Public notes

Principal investigator
Name 0 0
Reece C Hall, MBChB
Address 0 0
Capital Coast District Health Board
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Reece C Hall, MBChB
Address 0 0
Country 0 0
Phone 0 0
0064 4 3855999
Fax 0 0
Email 0 0
Contact person for scientific queries

No data has been provided for results reporting
Summary results
Not applicable