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Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
Affect Recognition: Enhancing Performance of Persons With Acquired Brain Injury (ABI)
Scientific title
Controlled Study of Affect Recognition Training for Individuals With Acquired Brain Injury
Secondary ID [1] 0 0
NIDRR H133G080043A
Secondary ID [2] 0 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Acquired Brain Injury (Including Stroke) 0 0
Condition category
Condition code
Skin 0 0 0 0
Other skin conditions
Injuries and Accidents 0 0 0 0
Other injuries and accidents
Neurological 0 0 0 0
Other neurological disorders

Study type
Description of intervention(s) / exposure
Behaviour - Facial Affect Recognition Training
Other interventions - Stories of Emotional Inference

Experimental: FAR - Facial affect recognition training (with computer assistance)

Experimental: SEI - Stories of Emotional Inference

Behaviour: Facial Affect Recognition Training
A series of pictures of faces displaying various emotions are presented one at a time using a computerized training program.Participants are taught to recognize how emotions affect facial features such as the mouth and eyes.Participants are also taught how to recognize their own emotions.

Other interventions: Stories of Emotional Inference
Participants are presented with a series of short stories one at a time. Each story presents various contextual cues regarding the emotions the characters are likely to experience. Participants learn to connect the cues to specific emotions.

Intervention code [1] 0 0
Intervention code [2] 0 0
Other interventions
Comparator / control treatment
Control group

Primary outcome [1] 0 0
Diagnostic Assessment of Nonverbal Affect-Adult Faces (DANVA2-AF)
Timepoint [1] 0 0
Seven months
Primary outcome [2] 0 0
Emotional Inference From Stories Test
Timepoint [2] 0 0
Seven months
Secondary outcome [1] 0 0
Interpersonal Reactivity Index
Timepoint [1] 0 0
Seven Months
Secondary outcome [2] 0 0
Neuropsychiatric Inventory
Timepoint [2] 0 0
Seven Months

Key inclusion criteria
- Age between eighteen and sixty-five years old.

- At minimum, one year post-injury.

- Glasgow Coma Score (GCS) of 12 or less, or stroke with hemi-paresis signifying a
moderate to severe acquired brain injury.

- A TBI that resulted in either a closed or open head injury or a stroke that resulted
in severe disability

- Perform at least one standard deviation below the norm on the DANVA2-Adult Faces test,
a standardized assessment of facial affect recognition.

- Verbally able to express a basic understanding of emotional descriptors (e.g. Happy,
sad, angry, fearful).

- Demonstrate basic comprehension for short paragraphs presented in 2 ways: 1)auditorily
and 2)silent reading. This measure is part of the Discourse Comprehension Test.
Minimum age
18 Years
Maximum age
65 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- Diagnosed mental illness.

- Uncorrected visual acuity.

- Uncorrected hearing impairment.

- Perceptual impairment (visual neglect and/or visual discrimination).

- Impaired verbal expression/ aphasia

- Alcohol or substance abuse.

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?

The people assessing the outcomes
Intervention assignment
Other design features
Phase 2/Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
New York
Country [2] 0 0
United States of America
State/province [2] 0 0
North Carolina
Country [3] 0 0
State/province [3] 0 0
Country [4] 0 0
New Zealand
State/province [4] 0 0

Funding & Sponsors
Primary sponsor type
University at Buffalo
Other collaborator category [1] 0 0
Government body
Name [1] 0 0
U.S. Department of Education
Address [1] 0 0
Country [1] 0 0
Other collaborator category [2] 0 0
Name [2] 0 0
Massey University
Address [2] 0 0
Country [2] 0 0
Other collaborator category [3] 0 0
Name [3] 0 0
Carolinas Healthcare System
Address [3] 0 0
Country [3] 0 0
Other collaborator category [4] 0 0
Name [4] 0 0
Brock University
Address [4] 0 0
Country [4] 0 0

Ethics approval
Ethics application status

Brief summary
The purpose of this research is to evaluate the effectiveness of three training programs
designed to teach persons with acquired brain injury (ABI) to recognize emotions. It is
hypothesized that the training programs will enhance several aspects of emotion recognition
in persons with ABI. Furthermore, it is expected that these effects will be maintained over
time, and will positively influence participants' social behavior and integration.
Trial website
Trial related presentations / publications
Zupan B, Neumann D, Babbage DR, Willer B. The importance of vocal affect to bimodal processing of emotion: implications for individuals with traumatic brain injury. J Commun Disord. 2009 Jan-Feb;42(1):1-17. doi: 10.1016/j.jcomdis.2008.06.001. Epub 2008 Jul 9. Review.
Radice-Neumann D, Zupan B, Babbage DR, Willer B. Overview of impaired facial affect recognition in persons with traumatic brain injury. Brain Inj. 2007 Jul;21(8):807-16. Review.
Radice-Neumann D, Zupan B, Tomita M, Willer B. Training emotional processing in persons with brain injury. J Head Trauma Rehabil. 2009 Sep-Oct;24(5):313-23. doi: 10.1097/HTR.0b013e3181b09160.
Babbage DR, Yim J, Zupan B, Neumann D, Tomita MR, Willer B. Meta-analysis of facial affect recognition difficulties after traumatic brain injury. Neuropsychology. 2011 May;25(3):277-85. doi: 10.1037/a0021908.
Public notes

Principal investigator
Name 0 0
Barry Willer, Ph.D.
Address 0 0
University at Buffalo, Department of Psychiatry
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

No data has been provided for results reporting
Summary results
Other publications