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Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
IMPROVinG Outcomes in Community Acquired Pneumonia
Scientific title
Evaluating the Impact of a New Model of Care Designed to Improve Evidence-based Management of Community-acquired Pneumonia
Secondary ID [1] 0 0
MH 2016.014
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Pneumonia 0 0
Condition category
Condition code
Respiratory 0 0 0 0
Other respiratory disorders / diseases
Infection 0 0 0 0
Other infectious diseases
Infection 0 0 0 0
Studies of infection and infectious agents

Study type
Description of intervention(s) / exposure
Other interventions - New model of service delivery
Other interventions - Current practice

Experimental: CAP Service -

Active Comparator: Usual care -

Other interventions: New model of service delivery
Introduction of a new CAP disease specific clinical team to ensure systematic implementation of standardized treatment protocols (similar to a clinical pathway) for interventions supported by Level-1 evidence.

Other interventions: Current practice
Interventions as determined by the treating General Medical team consistent with current usual practice.

Intervention code [1] 0 0
Other interventions
Comparator / control treatment
Control group

Primary outcome [1] 0 0
Hospital length of stay
Timepoint [1] 0 0
Through study completion, an average of five days
Secondary outcome [1] 0 0
Hospital readmissions
Timepoint [1] 0 0
Within 30-days and 90-days of discharge
Secondary outcome [2] 0 0
Individual per-separation admission costing - Total cost per admission that can be directly attributed to patient inpatient stay as recorded by the Power Performance Manager software platform.
Timepoint [2] 0 0
From admission to emergency department until 90-days post-discharge
Secondary outcome [3] 0 0
In-hospital mortality
Timepoint [3] 0 0
15 months
Secondary outcome [4] 0 0
Proportion of patients receiving each individual evidence-based treatment recommendation
Timepoint [4] 0 0
15 months
Secondary outcome [5] 0 0
Proportion of patients receiving all evidence-based treatment recommendations
Timepoint [5] 0 0
Secondary outcome [6] 0 0
Incidence of hyperglycaemia in known diabetics requiring new insulin prescription
Timepoint [6] 0 0
Secondary outcome [7] 0 0
Falls or clinical deterioration during physiotherapy
Timepoint [7] 0 0
Secondary outcome [8] 0 0
Admission to Intensive Care Unit from medical ward during admission - Does not include admissions to ICU directly from the Emergency Department
Timepoint [8] 0 0
Secondary outcome [9] 0 0
Duration of mechanical ventilation and number of failed extubations
Timepoint [9] 0 0
Secondary outcome [10] 0 0
Death within 30-days of presentation to hospital
Timepoint [10] 0 0
30-days from date of presentation to the Emergency Department
Secondary outcome [11] 0 0
Death within 90-days of presentation to hospital
Timepoint [11] 0 0
90-days from date of presentation to the Emergency Department

Key inclusion criteria
- Patients presenting to Footscray or Sunshine Hospital meeting the standardized
definition for community acquired pneumonia.
Minimum age
18 Years
Maximum age
No limit
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- Palliated on admission.

- Enrolled in another inpatient clinical trial.

Withdrawal Criteria:

- Transferred to a non-General Medical Unit within 48-hours of admission.

- Transferred to another health service within 48-hours of admission.

Study design
Purpose of the study
Health Services Research
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s

The people assessing the outcomes
Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
Footscray Hospital - Footscray
Recruitment hospital [2] 0 0
Sunshine Hospital - St Albans
Recruitment postcode(s) [1] 0 0
3011 - Footscray
Recruitment postcode(s) [2] 0 0
3442 - St Albans

Funding & Sponsors
Primary sponsor type
Western Health, Australia
Other collaborator category [1] 0 0
Name [1] 0 0
University of Melbourne
Address [1] 0 0
Country [1] 0 0
Other collaborator category [2] 0 0
Name [2] 0 0
Monash University
Address [2] 0 0
Country [2] 0 0
Other collaborator category [3] 0 0
Name [3] 0 0
La Trobe University
Address [3] 0 0
Country [3] 0 0

Ethics approval
Ethics application status

Brief summary
Pneumonia is the commonest illness requiring hospitalization in Australia. Elderly patients
account for most admissions and incur highest costs due to longer hospitalizations, higher
readmission risks and poor functional outcomes. Previous clinical trials show a number of
medical and allied health interventions can effectively shorten hospitalization or reduce
readmissions, but these have been poorly and inconsistently applied in practice. This
proposed research builds on previous studies by applying these interventions as a
standardized combined package, evaluating their effectiveness in a "real world" Australian
setting and quantifying effects on both clinical outcomes and health service costs.
Trial website
Trial related presentations / publications
Blum CA, Nigro N, Briel M, Schuetz P, Ullmer E, Suter-Widmer I, Winzeler B, Bingisser R, Elsaesser H, Drozdov D, Arici B, Urwyler SA, Refardt J, Tarr P, Wirz S, Thomann R, Baumgartner C, Duplain H, Burki D, Zimmerli W, Rodondi N, Mueller B, Christ-Crain M. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 2015 Apr 18;385(9977):1511-8. doi: 10.1016/S0140-6736(14)62447-8. Epub 2015 Jan 19.
Mundy LM, Leet TL, Darst K, Schnitzler MA, Dunagan WC. Early mobilization of patients hospitalized with community-acquired pneumonia. Chest. 2003 Sep;124(3):883-9.
Carratalà J, Garcia-Vidal C, Ortega L, Fernández-Sabé N, Clemente M, Albero G, López M, Castellsagué X, Dorca J, Verdaguer R, Martínez-Montauti J, Manresa F, Gudiol F. Effect of a 3-step critical pathway to reduce duration of intravenous antibiotic therapy and length of stay in community-acquired pneumonia: a randomized controlled trial. Arch Intern Med. 2012 Jun 25;172(12):922-8. doi: 10.1001/archinternmed.2012.1690.
Siemieniuk RA, Meade MO, Alonso-Coello P, Briel M, Evaniew N, Prasad M, Alexander PE, Fei Y, Vandvik PO, Loeb M, Guyatt GH. Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Ann Intern Med. 2015 Oct 6;163(7):519-28. doi: 10.7326/M15-0715. Review.
Marti C, Grosgurin O, Harbarth S, Combescure C, Abbas M, Rutschmann O, Perrier A, Garin N. Adjunctive Corticotherapy for Community Acquired Pneumonia: A Systematic Review and Meta-Analysis. PLoS One. 2015 Dec 7;10(12):e0144032. doi: 10.1371/journal.pone.0144032. eCollection 2015. Review.
Torres A, Sibila O, Ferrer M, Polverino E, Menendez R, Mensa J, Gabarrús A, Sellarés J, Restrepo MI, Anzueto A, Niederman MS, Agustí C. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA. 2015 Feb 17;313(7):677-86. doi: 10.1001/jama.2015.88.
Public notes

Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Summary results
Other publications