The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
Exercise Training and Walking Ability After Chronic Stroke
Scientific title
Does Aerobic or Resistance Exercise Training Improve Walking Ability in Chronic Stroke Patients?
Secondary ID [1] 0 0
NHMRC 153970
Secondary ID [2] 0 0
NHMRC 153970
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Stroke 0 0
Condition category
Condition code
Stroke 0 0 0 0
Stroke 0 0 0 0

Study type
Description of intervention(s) / exposure
Treatment: Surgery - [A] Aerobic isokinetic cycling exercise
Treatment: Surgery - [B] Progressive Resistance Training
Treatment: Surgery - [A] + [B]

Treatment: Surgery: [A] Aerobic isokinetic cycling exercise

Treatment: Surgery: [B] Progressive Resistance Training

Treatment: Surgery: [A] + [B]

Intervention code [1] 0 0
Treatment: Surgery
Comparator / control treatment
Control group

Primary outcome [1] 0 0
Subjects will undertake a 6 min walking test for maximum distance
Timepoint [1] 0 0
Secondary outcome [1] 0 0
Cardiorespiratory Fitness
Timepoint [1] 0 0
Secondary outcome [2] 0 0
Lower limb muscular strength and endurance
Timepoint [2] 0 0
Secondary outcome [3] 0 0
Mobility variables
Timepoint [3] 0 0
Secondary outcome [4] 0 0
Scales and questionnaires
Timepoint [4] 0 0

Key inclusion criteria
- Age > 45 years

- First stroke resulting in hemiplegia

- At least 4-months post stroke

- Residing at home or community-based (non-institutionalized) living environment

- Self selected gait velocity between 0.42 m/s to 0.80 m/s

- No longer receiving physiotherapy.

- Adequate comprehension of instructions and perceptual abilities (assessed by stroke
clinician during medical screening), no significant musculotendinous or bony
restrictions of the affected limb, nor any serious chronic disease independently
causing significant disability or profound atrophy of the affected limb will comprise
further indications to participation
Minimum age
45 Years
Maximum age
90 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- Subjects will be excluded if they have significant cardiac disease, symptom limiting
peripheral vascular disease, or any of the exclusion criteria contraindicating
moderate exercise as outlined by the American College of Sports Medicine guidelines
for cardiac disease rehabilitation or for frail and elderly adults. The initial
symptom-limited/maximal aerobic assessment will serve as the screening test for
contraindications to further exercise.

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
Rehabilitation Research Centre, University of Sydney - Sydney
Recruitment postcode(s) [1] 0 0
2141 - Sydney

Funding & Sponsors
Primary sponsor type
University of Sydney

Ethics approval
Ethics application status

Brief summary
This study will investigate the efficacy of aerobic exercise and progressive resistance
training (PRT), singularly and combined, on changes in walking endurance for
mildly-to-moderately affected chronic stroke patients. Specifically, we will determine the
relative importance of training induced changes in muscle strength versus aerobic fitness on
increases in gait velocity and 6-min walking distance, and assess the concomitant functional
and psychosocial impact of increased muscle strength, aerobic fitness and improved gait. This
longitudinal study will be conducted as a double blinded factorial randomized controlled
trial of exercise training for chronic stroke patients.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Summary results
Other publications