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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/show/NCT01877915




Registration number
NCT01877915
Ethics application status
Date submitted
12/06/2013
Date registered
14/06/2013
Date last updated
10/05/2019

Titles & IDs
Public title
A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure
Scientific title
A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Rivaroxaban With Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects With Heart Failure and Significant Coronary Artery Disease Following an Episode of Decompensated Heart Failure
Secondary ID [1] 0 0
RIVAROXHFA3001
Secondary ID [2] 0 0
CR101940
Universal Trial Number (UTN)
Trial acronym
COMMANDER HF
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Heart Failure 0 0
Coronary Artery Disease 0 0
Condition category
Condition code
Cardiovascular 0 0 0 0
Coronary heart disease
Cardiovascular 0 0 0 0
Other cardiovascular diseases

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Rivaroxaban
Treatment: Drugs - Placebo
Other interventions - Standard of care for heart failure and coronary artery disease

Experimental: Rivaroxaban 2.5 mg - Each participant will receive 2.5 mg of rivaroxaban twice daily with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).

Placebo Comparator: Placebo - Each participant will receive matching placebo twice daily with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).


Treatment: Drugs: Rivaroxaban
Each participant, randomly allocated to the rivaroxaban arm, will receive one 2.5 mg tablet of rivaroxaban orally (by mouth) twice daily (once in the morning and once in the evening at approximately the same time each day) until the global treatment end date (GTED) (defined as the date when 1200 primary efficacy outcome events have occurred). Rivaroxaban will be given with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).

Treatment: Drugs: Placebo
Each participant, randomly allocated to the placebo arm, will receive one matching placebo tablet orally twice daily (once in the morning and once in the evening at approximately the same time each day) until the GTED. Placebo will be given with standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician).

Other interventions: Standard of care for heart failure and coronary artery disease
Each participant's standard of care for heart failure and coronary artery disease (as prescribed by the participant's managing physician) should be continued throughout the study.

Intervention code [1] 0 0
Treatment: Drugs
Intervention code [2] 0 0
Other interventions
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Event Rate of All-Cause Mortality, Myocardial Infarction (MI), or Stroke - Event Rate of all-cause mortality (ACM), MI, or stroke were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 patient [pt]-year [yr]) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [1] 0 0
Up to Global treatment end date (approximately 54 months)
Primary outcome [2] 0 0
Event Rate of Either Fatal Bleeding or Bleeding Into a Critical Space With Potential for Permanent Disability - Event rate of either fatal bleeding or bleeding into critical space with potential for permanent disability were assessed. Fatal bleeding event was death within 7 days after a bleeding event which required hospitalization or met International Society on Thrombosis and Haemostasis(ISTH) major bleeding definition criteria. Fatal bleeding events included those met criteria in 3 categories: 1: Any ISTH major bleeding event consider primary cause of death by investigator; 2: Any ISTH major bleeding event not considered to be primary cause of death by investigator but resulted in death within 7 days;3: Any bleeding event resulted in hospital stay and death within 7 days. Bleeding into critical space with potential for permanent disability included 7 critical spaces: intracranial, intraspinal, intraocular. Event rate estimated based on time to first occurrence of event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [2] 0 0
Up to 227 Weeks
Secondary outcome [1] 0 0
Event Rate of Cardio Vascular Death or Re-Hospitalization for Worsening of Heart Failure (RHHF) - Event rate of cardio vascular (CV) death or re-hospitalization for worsening of heart failure were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [1] 0 0
Up to Global treatment end date (approximately 54 months)
Secondary outcome [2] 0 0
Event Rate of Cardio Vascular Death - Event rate of cardio vascular death were assessed. CV death included deaths due to spontaneous bleeding, MI, stroke, worsening HF and arrhythmias, death due to CV procedures and sudden death. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [2] 0 0
Up to Global treatment end date (approximately 54 months)
Secondary outcome [3] 0 0
Event Rate of Re-Hospitalization for Worsening of Heart Failure - Event rate of re-hospitalization for worsening of heart failure were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [3] 0 0
Up to Global treatment end date (approximately 54 months)
Secondary outcome [4] 0 0
Event Rate of Re-Hospitalization for Cardio Vascular Events (RHCV) - Event rate due to cardio vascular events were assessed. Hospitalization for a CV Event required that participants be hospitalized (in-patient or emergency department) for greater than 24 hours and must have met the following criterion:Discharge summary with primary reason for admission listed as CV in nature (example, bleeding, arrhythmia, ACS, MI) other than HF which was captured in the HF re-hospitalization. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [4] 0 0
Up to Global treatment end date (approximately 54 months)
Secondary outcome [5] 0 0
Event Rate of All-Cause Mortality (ACM) or Re-Hospitalization for Worsening Heart Failure - Event rate of all-Cause Mortality (ACM) or re-Hospitalization for worsening heart failure were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [5] 0 0
Up to Global treatment end date (approximately 54 months)
Secondary outcome [6] 0 0
Event Rate of Bleeding Events That Requiring Hospitalization - Event rate of bleeding events and required Hospitalization were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [6] 0 0
Up to 227 Weeks
Secondary outcome [7] 0 0
Event Rate of International Society on Thrombosis and Haemostasis (ISTH) Major Bleeding Event - Event rate of ISTH major bleeding event were assessed. Event rate estimated based on the time to the first occurrence of the event were reported in the study. Event Rate / (100 pt-yr) = 100*n/(total risk exposure), where n is the number of events.
Timepoint [7] 0 0
Up to 227 Weeks

Eligibility
Key inclusion criteria
- Must have symptomatic heart failure for at least 3 months prior to Screening

- Participants must have an episode of decompensated heart failure (index event)
requiring (a) an overnight stay [that is, staying past midnight] in a hospital,
emergency department, or medical facility with the capability of treating with
intravenous medications and observing heart failure patients before randomization or
(b) an unscheduled outpatient visit to a heart failure management center, where
parenteral therapy is required for heart failure stabilization. An episode of
decompensated heart failure is defined as symptoms of worsening dyspnea or fatigue,
objective signs of congestion such as peripheral edema or ascites, and/or adjustment
of pre-hospitalization/outpatient visit heart failure medications. Participants are
eligible for randomization at discharge from the facility treating the index event and
up to 30 days after discharge if they are in stable condition

- Must have a documented left ventricular ejection fraction (LVEF) of less than or equal
to 40 percent (%) within 1 year before randomization

- Must have evidence of significant coronary artery disease

- Must be medically stable in terms of their heart failure clinical status at the time
of randomization

- Must have a brain natriuretic peptide (BNP) level greater than or equal to (>=) 200
picogram per milliliter (pg/mL) or N-terminal-proBNP (NT-proBNP) level >=800 pg/mL
(preferred assay) during the Screening period and before randomization
Minimum age
18 Years
Maximum age
95 Years
Gender
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
- Any condition that, in the opinion of the investigator, contraindicates anticoagulant
therapy or would have an unacceptable risk of bleeding, such as, but not limited to,
active internal bleeding, clinically significant bleeding, bleeding at a
noncompressible site, or bleeding diathesis within 28 days of randomization

- Severe concomitant disease such as (a) atrial fibrillation (AFib) or another condition
that requires chronic anticoagulation (participants with isolated transient AFib may
be allowed at the discretion of the treating physician investigator) and (b)
Documented acute myocardial infarction (MI) during index event

- Prior stroke within 90 days of randomization

- Has been hospitalized for longer than 21 days during the index event

- Planned intermittent outpatient treatment with positive inotropic drugs administered
intravenously

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
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- Bedford
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- Cairns
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- Concord
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- Darlinghurst
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- Hobart
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- Launceston
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- Perth
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- Sydney
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- Wollongong
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- Woolloongabba
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- Bedford
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- Launceston
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- Perth
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- Sydney
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- Wollongong
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- Woolloongabba
Recruitment outside Australia
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State/province [170] 0 0
Heidelberg
Country [171] 0 0
Germany
State/province [171] 0 0
Konstanz
Country [172] 0 0
Germany
State/province [172] 0 0
Langen
Country [173] 0 0
Germany
State/province [173] 0 0
Leipzig
Country [174] 0 0
Germany
State/province [174] 0 0
Ludwigshafen
Country [175] 0 0
Germany
State/province [175] 0 0
Magdeburg
Country [176] 0 0
Germany
State/province [176] 0 0
Mainz
Country [177] 0 0
Germany
State/province [177] 0 0
Markkleeberg
Country [178] 0 0
Germany
State/province [178] 0 0
Papenburg
Country [179] 0 0
Germany
State/province [179] 0 0
Stuttgart
Country [180] 0 0
Germany
State/province [180] 0 0
Ulm
Country [181] 0 0
Germany
State/province [181] 0 0
Witten
Country [182] 0 0
Greece
State/province [182] 0 0
Athens
Country [183] 0 0
Greece
State/province [183] 0 0
Heraklion -Crete
Country [184] 0 0
Greece
State/province [184] 0 0
Larisa
Country [185] 0 0
Greece
State/province [185] 0 0
Thessalonikis
Country [186] 0 0
Greece
State/province [186] 0 0
Voula
Country [187] 0 0
Hungary
State/province [187] 0 0
Balatonfüred
Country [188] 0 0
Hungary
State/province [188] 0 0
Berettyóújfalu
Country [189] 0 0
Hungary
State/province [189] 0 0
Budapest
Country [190] 0 0
Hungary
State/province [190] 0 0
Gyor
Country [191] 0 0
Hungary
State/province [191] 0 0
Miskolc
Country [192] 0 0
Hungary
State/province [192] 0 0
Nagykanizsa
Country [193] 0 0
Hungary
State/province [193] 0 0
Szekszárd
Country [194] 0 0
Hungary
State/province [194] 0 0
Szolnok
Country [195] 0 0
Hungary
State/province [195] 0 0
Székesfehérvár
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Hungary
State/province [196] 0 0
Zalaegerszeg
Country [197] 0 0
Japan
State/province [197] 0 0
Aichi
Country [198] 0 0
Japan
State/province [198] 0 0
Chiba
Country [199] 0 0
Japan
State/province [199] 0 0
Chikushino-shi
Country [200] 0 0
Japan
State/province [200] 0 0
Ehime
Country [201] 0 0
Japan
State/province [201] 0 0
Fukuoka
Country [202] 0 0
Japan
State/province [202] 0 0
Gifu
Country [203] 0 0
Japan
State/province [203] 0 0
Gunma
Country [204] 0 0
Japan
State/province [204] 0 0
Hatsukaichi
Country [205] 0 0
Japan
State/province [205] 0 0
Hitachi
Country [206] 0 0
Japan
State/province [206] 0 0
Hokkaido
Country [207] 0 0
Japan
State/province [207] 0 0
Hyogo
Country [208] 0 0
Japan
State/province [208] 0 0
Ibaraki
Country [209] 0 0
Japan
State/province [209] 0 0
Ishikawa
Country [210] 0 0
Japan
State/province [210] 0 0
Izumo
Country [211] 0 0
Japan
State/province [211] 0 0
Kagawa
Country [212] 0 0
Japan
State/province [212] 0 0
Kahoku-District
Country [213] 0 0
Japan
State/province [213] 0 0
Kanagawa
Country [214] 0 0
Japan
State/province [214] 0 0
Kobe-shi
Country [215] 0 0
Japan
State/province [215] 0 0
Komatsushima-shi
Country [216] 0 0
Japan
State/province [216] 0 0
Koshigaya-shi
Country [217] 0 0
Japan
State/province [217] 0 0
Kumamoto
Country [218] 0 0
Japan
State/province [218] 0 0
Kyoto
Country [219] 0 0
Japan
State/province [219] 0 0
Miyazaki
Country [220] 0 0
Japan
State/province [220] 0 0
Nagano-shi
Country [221] 0 0
Japan
State/province [221] 0 0
Nagano
Country [222] 0 0
Japan
State/province [222] 0 0
Nagasaki
Country [223] 0 0
Japan
State/province [223] 0 0
Nagoya
Country [224] 0 0
Japan
State/province [224] 0 0
Niigata
Country [225] 0 0
Japan
State/province [225] 0 0
Oita
Country [226] 0 0
Japan
State/province [226] 0 0
Okayama
Country [227] 0 0
Japan
State/province [227] 0 0
Okinawa
Country [228] 0 0
Japan
State/province [228] 0 0
Osaka-shi
Country [229] 0 0
Japan
State/province [229] 0 0
Osaka
Country [230] 0 0
Japan
State/province [230] 0 0
Saga
Country [231] 0 0
Japan
State/province [231] 0 0
Saitama
Country [232] 0 0
Japan
State/province [232] 0 0
Sapporo
Country [233] 0 0
Japan
State/province [233] 0 0
Sendai
Country [234] 0 0
Japan
State/province [234] 0 0
Shiga
Country [235] 0 0
Japan
State/province [235] 0 0
Shimane
Country [236] 0 0
Japan
State/province [236] 0 0
Shizuoka
Country [237] 0 0
Japan
State/province [237] 0 0
Tachikawa
Country [238] 0 0
Japan
State/province [238] 0 0
Takaraduka
Country [239] 0 0
Japan
State/province [239] 0 0
Tochigi
Country [240] 0 0
Japan
State/province [240] 0 0
Tokushima
Country [241] 0 0
Japan
State/province [241] 0 0
Tokyo
Country [242] 0 0
Japan
State/province [242] 0 0
Toyama
Country [243] 0 0
Japan
State/province [243] 0 0
Toyoake
Country [244] 0 0
Japan
State/province [244] 0 0
Tsu
Country [245] 0 0
Japan
State/province [245] 0 0
Wakayama
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Japan
State/province [246] 0 0
Yamaguchi
Country [247] 0 0
Japan
State/province [247] 0 0
Yatsushiro
Country [248] 0 0
Japan
State/province [248] 0 0
Yokohama
Country [249] 0 0
Japan
State/province [249] 0 0
Yonago
Country [250] 0 0
Korea, Republic of
State/province [250] 0 0
Busan
Country [251] 0 0
Korea, Republic of
State/province [251] 0 0
Cheongju
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Korea, Republic of
State/province [252] 0 0
Daegu
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Korea, Republic of
State/province [253] 0 0
Daejeon
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Korea, Republic of
State/province [254] 0 0
Gwangju
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Korea, Republic of
State/province [255] 0 0
Seongnam-si
Country [256] 0 0
Korea, Republic of
State/province [256] 0 0
Seoul
Country [257] 0 0
Korea, Republic of
State/province [257] 0 0
Wonju
Country [258] 0 0
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Daugavpils
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Latvia
State/province [259] 0 0
Kuldiga
Country [260] 0 0
Latvia
State/province [260] 0 0
Liepaja
Country [261] 0 0
Latvia
State/province [261] 0 0
Riga
Country [262] 0 0
Latvia
State/province [262] 0 0
Sigulda
Country [263] 0 0
Latvia
State/province [263] 0 0
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Country [264] 0 0
Lithuania
State/province [264] 0 0
Alytus
Country [265] 0 0
Lithuania
State/province [265] 0 0
Kaunas
Country [266] 0 0
Lithuania
State/province [266] 0 0
Klaipeda
Country [267] 0 0
Lithuania
State/province [267] 0 0
Panevezys
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Lithuania
State/province [268] 0 0
Siauliai
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Lithuania
State/province [269] 0 0
Vilnius
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Malaysia
State/province [270] 0 0
Cheras
Country [271] 0 0
Malaysia
State/province [271] 0 0
Johor Bahru
Country [272] 0 0
Malaysia
State/province [272] 0 0
Kota Kinabalu
Country [273] 0 0
Malaysia
State/province [273] 0 0
Kuala Lumpur
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Malaysia
State/province [274] 0 0
Kuching
Country [275] 0 0
Malaysia
State/province [275] 0 0
Penang
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Malaysia
State/province [276] 0 0
Selangor
Country [277] 0 0
Malaysia
State/province [277] 0 0
Selayang
Country [278] 0 0
Mexico
State/province [278] 0 0
Aguascalientes
Country [279] 0 0
Mexico
State/province [279] 0 0
Benito Juárez
Country [280] 0 0
Mexico
State/province [280] 0 0
Chihuahua
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Mexico
State/province [281] 0 0
Culiacan
Country [282] 0 0
Mexico
State/province [282] 0 0
Durango
Country [283] 0 0
Mexico
State/province [283] 0 0
Guadalajara
Country [284] 0 0
Mexico
State/province [284] 0 0
León
Country [285] 0 0
Mexico
State/province [285] 0 0
Mexico City
Country [286] 0 0
Mexico
State/province [286] 0 0
Mexico
Country [287] 0 0
Mexico
State/province [287] 0 0
Oaxaca
Country [288] 0 0
Mexico
State/province [288] 0 0
Pachuca
Country [289] 0 0
Mexico
State/province [289] 0 0
Puebla
Country [290] 0 0
Mexico
State/province [290] 0 0
Queretaro
Country [291] 0 0
Mexico
State/province [291] 0 0
San Luis Potosí
Country [292] 0 0
Mexico
State/province [292] 0 0
Tampico
Country [293] 0 0
Mexico
State/province [293] 0 0
Veracruz
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Netherlands
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Almere
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Netherlands
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Amsterdam
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Netherlands
State/province [296] 0 0
Blaricum
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Netherlands
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Breda
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Netherlands
State/province [298] 0 0
Deventer
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Netherlands
State/province [299] 0 0
Doetinchem
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Netherlands
State/province [300] 0 0
Ede
Country [301] 0 0
Netherlands
State/province [301] 0 0
Groningen
Country [302] 0 0
Netherlands
State/province [302] 0 0
Heerlen
Country [303] 0 0
Netherlands
State/province [303] 0 0
Helmond
Country [304] 0 0
Netherlands
State/province [304] 0 0
Maastricht
Country [305] 0 0
Netherlands
State/province [305] 0 0
Meppel
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Netherlands
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Tilburg
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Poland
State/province [307] 0 0
Bedzin
Country [308] 0 0
Poland
State/province [308] 0 0
Gdynia
Country [309] 0 0
Poland
State/province [309] 0 0
Gliwice
Country [310] 0 0
Poland
State/province [310] 0 0
Grodzisk Mazowiecki
Country [311] 0 0
Poland
State/province [311] 0 0
Inowroclaw
Country [312] 0 0
Poland
State/province [312] 0 0
Katowice
Country [313] 0 0
Poland
State/province [313] 0 0
Kielce
Country [314] 0 0
Poland
State/province [314] 0 0
Krakow
Country [315] 0 0
Poland
State/province [315] 0 0
Kraków
Country [316] 0 0
Poland
State/province [316] 0 0
Kutno
Country [317] 0 0
Poland
State/province [317] 0 0
Lodz
Country [318] 0 0
Poland
State/province [318] 0 0
Lubin
Country [319] 0 0
Poland
State/province [319] 0 0
Lublin
Country [320] 0 0
Poland
State/province [320] 0 0
Myslenice
Country [321] 0 0
Poland
State/province [321] 0 0
Olsztyn
Country [322] 0 0
Poland
State/province [322] 0 0
Ostroleka
Country [323] 0 0
Poland
State/province [323] 0 0
Ostrowiec Swietokrzyski
Country [324] 0 0
Poland
State/province [324] 0 0
Oswiecim
Country [325] 0 0
Poland
State/province [325] 0 0
Plock
Country [326] 0 0
Poland
State/province [326] 0 0
Pulawy
Country [327] 0 0
Poland
State/province [327] 0 0
Rabka-Zdrój
Country [328] 0 0
Poland
State/province [328] 0 0
Skierniewice
Country [329] 0 0
Poland
State/province [329] 0 0
Starogard Gdanski
Country [330] 0 0
Poland
State/province [330] 0 0
Szczecin
Country [331] 0 0
Poland
State/province [331] 0 0
Torun
Country [332] 0 0
Poland
State/province [332] 0 0
Warszawa
Country [333] 0 0
Poland
State/province [333] 0 0
Wloclawek
Country [334] 0 0
Poland
State/province [334] 0 0
Wroclaw
Country [335] 0 0
Poland
State/province [335] 0 0
Zabrze
Country [336] 0 0
Poland
State/province [336] 0 0
Zamosc
Country [337] 0 0
Poland
State/province [337] 0 0
Lódz
Country [338] 0 0
Portugal
State/province [338] 0 0
Almada
Country [339] 0 0
Portugal
State/province [339] 0 0
Aveiro
Country [340] 0 0
Portugal
State/province [340] 0 0
Braga
Country [341] 0 0
Portugal
State/province [341] 0 0
Carnaxide
Country [342] 0 0
Portugal
State/province [342] 0 0
Coimbra
Country [343] 0 0
Portugal
State/province [343] 0 0
Covilhã
Country [344] 0 0
Portugal
State/province [344] 0 0
Leiria
Country [345] 0 0
Portugal
State/province [345] 0 0
Lisboa
Country [346] 0 0
Portugal
State/province [346] 0 0
Matosinhos
Country [347] 0 0
Portugal
State/province [347] 0 0
Viana do Castelo
Country [348] 0 0
Portugal
State/province [348] 0 0
Vila Real
Country [349] 0 0
Romania
State/province [349] 0 0
Bacau
Country [350] 0 0
Romania
State/province [350] 0 0
Baia Mare
Country [351] 0 0
Romania
State/province [351] 0 0
Braila
Country [352] 0 0
Romania
State/province [352] 0 0
Brasov
Country [353] 0 0
Romania
State/province [353] 0 0
Bucharest
Country [354] 0 0
Romania
State/province [354] 0 0
Bucuresti
Country [355] 0 0
Romania
State/province [355] 0 0
Buzau
Country [356] 0 0
Romania
State/province [356] 0 0
Cluj Napoca
Country [357] 0 0
Romania
State/province [357] 0 0
Cluj-Napoca
Country [358] 0 0
Romania
State/province [358] 0 0
Craiova
Country [359] 0 0
Romania
State/province [359] 0 0
Focsani
Country [360] 0 0
Romania
State/province [360] 0 0
Galati
Country [361] 0 0
Romania
State/province [361] 0 0
Iasi
Country [362] 0 0
Romania
State/province [362] 0 0
Oradea
Country [363] 0 0
Romania
State/province [363] 0 0
Pitesti
Country [364] 0 0
Romania
State/province [364] 0 0
Sibiu
Country [365] 0 0
Romania
State/province [365] 0 0
Targu Mures
Country [366] 0 0
Romania
State/province [366] 0 0
Targu-Mures
Country [367] 0 0
Romania
State/province [367] 0 0
Timisoara
Country [368] 0 0
Russian Federation
State/province [368] 0 0
Arkhangelsk
Country [369] 0 0
Russian Federation
State/province [369] 0 0
Barnaul
Country [370] 0 0
Russian Federation
State/province [370] 0 0
Chita
Country [371] 0 0
Russian Federation
State/province [371] 0 0
Ekaterinburg
Country [372] 0 0
Russian Federation
State/province [372] 0 0
Ivanovo
Country [373] 0 0
Russian Federation
State/province [373] 0 0
Izhevsk
Country [374] 0 0
Russian Federation
State/province [374] 0 0
Kaluga
Country [375] 0 0
Russian Federation
State/province [375] 0 0
Kemerovo
Country [376] 0 0
Russian Federation
State/province [376] 0 0
Kirov
Country [377] 0 0
Russian Federation
State/province [377] 0 0
Krasnoyarsk
Country [378] 0 0
Russian Federation
State/province [378] 0 0
Kursk
Country [379] 0 0
Russian Federation
State/province [379] 0 0
Moscow, Zelenograd
Country [380] 0 0
Russian Federation
State/province [380] 0 0
Moscow
Country [381] 0 0
Russian Federation
State/province [381] 0 0
Nizhniy Novgorod
Country [382] 0 0
Russian Federation
State/province [382] 0 0
Nizhny Novgorod
Country [383] 0 0
Russian Federation
State/province [383] 0 0
Novosibirsk
Country [384] 0 0
Russian Federation
State/province [384] 0 0
Orenburg
Country [385] 0 0
Russian Federation
State/province [385] 0 0
Perm
Country [386] 0 0
Russian Federation
State/province [386] 0 0
Rostov on Don
Country [387] 0 0
Russian Federation
State/province [387] 0 0
Ryazan
Country [388] 0 0
Russian Federation
State/province [388] 0 0
Saint Petersburg
Country [389] 0 0
Russian Federation
State/province [389] 0 0
Samara
Country [390] 0 0
Russian Federation
State/province [390] 0 0
Saratov
Country [391] 0 0
Russian Federation
State/province [391] 0 0
Syktyvkar
Country [392] 0 0
Russian Federation
State/province [392] 0 0
Tomsk
Country [393] 0 0
Russian Federation
State/province [393] 0 0
Tyumen
Country [394] 0 0
Russian Federation
State/province [394] 0 0
Voronezh
Country [395] 0 0
Russian Federation
State/province [395] 0 0
Yaroslavl
Country [396] 0 0
Slovakia
State/province [396] 0 0
Banska Bystrica
Country [397] 0 0
Slovakia
State/province [397] 0 0
Bardejov
Country [398] 0 0
Slovakia
State/province [398] 0 0
Kosice
Country [399] 0 0
Slovakia
State/province [399] 0 0
Lucenec
Country [400] 0 0
Slovakia
State/province [400] 0 0
Moldava nad Bodvou
Country [401] 0 0
Slovakia
State/province [401] 0 0
Nitra
Country [402] 0 0
Slovakia
State/province [402] 0 0
Povazska Bystrica
Country [403] 0 0
Slovakia
State/province [403] 0 0
Svidnik
Country [404] 0 0
South Africa
State/province [404] 0 0
Bloemfontein
Country [405] 0 0
South Africa
State/province [405] 0 0
Cape Town
Country [406] 0 0
South Africa
State/province [406] 0 0
Centurion
Country [407] 0 0
South Africa
State/province [407] 0 0
Durban
Country [408] 0 0
South Africa
State/province [408] 0 0
Pinelands
Country [409] 0 0
South Africa
State/province [409] 0 0
Pretoria
Country [410] 0 0
South Africa
State/province [410] 0 0
Tongaat
Country [411] 0 0
Spain
State/province [411] 0 0
A Coruña
Country [412] 0 0
Spain
State/province [412] 0 0
Alicante
Country [413] 0 0
Spain
State/province [413] 0 0
Almería
Country [414] 0 0
Spain
State/province [414] 0 0
Avila
Country [415] 0 0
Spain
State/province [415] 0 0
Barcelona
Country [416] 0 0
Spain
State/province [416] 0 0
Burgos
Country [417] 0 0
Spain
State/province [417] 0 0
Cáceres
Country [418] 0 0
Spain
State/province [418] 0 0
Elche
Country [419] 0 0
Spain
State/province [419] 0 0
Granada
Country [420] 0 0
Spain
State/province [420] 0 0
La Coruña
Country [421] 0 0
Spain
State/province [421] 0 0
Lorca
Country [422] 0 0
Spain
State/province [422] 0 0
Madrid
Country [423] 0 0
Spain
State/province [423] 0 0
Majadahonda
Country [424] 0 0
Spain
State/province [424] 0 0
Murcia
Country [425] 0 0
Spain
State/province [425] 0 0
Olot
Country [426] 0 0
Spain
State/province [426] 0 0
Orihuela
Country [427] 0 0
Spain
State/province [427] 0 0
Palma de Mallorca
Country [428] 0 0
Spain
State/province [428] 0 0
San Juan
Country [429] 0 0
Spain
State/province [429] 0 0
Sanlúcar de Barrameda
Country [430] 0 0
Spain
State/province [430] 0 0
Sant Joan Despí
Country [431] 0 0
Spain
State/province [431] 0 0
Santander
Country [432] 0 0
Spain
State/province [432] 0 0
Sevilla
Country [433] 0 0
Spain
State/province [433] 0 0
Terrassa
Country [434] 0 0
Spain
State/province [434] 0 0
Torrevieja
Country [435] 0 0
Spain
State/province [435] 0 0
Valencia
Country [436] 0 0
Spain
State/province [436] 0 0
Vigo
Country [437] 0 0
Spain
State/province [437] 0 0
Viladecans
Country [438] 0 0
Sweden
State/province [438] 0 0
Falun
Country [439] 0 0
Sweden
State/province [439] 0 0
Jönköping
Country [440] 0 0
Sweden
State/province [440] 0 0
Ljungby
Country [441] 0 0
Sweden
State/province [441] 0 0
Stockholm
Country [442] 0 0
Sweden
State/province [442] 0 0
Uppsala
Country [443] 0 0
Turkey
State/province [443] 0 0
Ankara
Country [444] 0 0
Turkey
State/province [444] 0 0
Bursa
Country [445] 0 0
Turkey
State/province [445] 0 0
Diyarbakir
Country [446] 0 0
Turkey
State/province [446] 0 0
Eskisehir
Country [447] 0 0
Turkey
State/province [447] 0 0
Istanbul
Country [448] 0 0
Turkey
State/province [448] 0 0
Kahramanmaras
Country [449] 0 0
Turkey
State/province [449] 0 0
Kocaeli
Country [450] 0 0
Turkey
State/province [450] 0 0
Konya
Country [451] 0 0
Turkey
State/province [451] 0 0
Kirikkale
Country [452] 0 0
Turkey
State/province [452] 0 0
Mersin
Country [453] 0 0
Turkey
State/province [453] 0 0
Sivas
Country [454] 0 0
Ukraine
State/province [454] 0 0
Cherkassy
Country [455] 0 0
Ukraine
State/province [455] 0 0
Cherkasy