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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/show/NCT02111564




Registration number
NCT02111564
Ethics application status
Date submitted
31/03/2014
Date registered
11/04/2014
Date last updated
25/11/2019

Titles & IDs
Public title
A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
Scientific title
Medically Ill Patient Assessment of Rivaroxaban Versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk
Secondary ID [1] 0 0
2014-000305-13
Secondary ID [2] 0 0
CR103834
Universal Trial Number (UTN)
Trial acronym
MARINER
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Heart Failure 0 0
Respiratory Insufficiency 0 0
Stroke Acute 0 0
Infectious Diseases 0 0
Rheumatic Diseases 0 0
Condition category
Condition code
Infection 0 0 0 0
Studies of infection and infectious agents
Infection 0 0 0 0
Other infectious diseases
Infection 0 0 0 0
Sexually transmitted infections
Inflammatory and Immune System 0 0 0 0
Rheumatoid arthritis
Musculoskeletal 0 0 0 0
Other muscular and skeletal disorders
Respiratory 0 0 0 0
Other respiratory disorders / diseases
Cardiovascular 0 0 0 0
Coronary heart disease
Cardiovascular 0 0 0 0
Other cardiovascular diseases
Cardiovascular 0 0 0 0
Diseases of the vasculature and circulation including the lymphatic system
Skin 0 0 0 0
Other skin conditions

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Rivaroxaban, 10 mg
Treatment: Drugs - Rivaroxaban, 7.5 mg
Treatment: Drugs - Placebo

Experimental: Rivaroxaban - Each patient will receive either 10 mg or 7.5 mg rivaroxaban tablet once daily orally (by mouth) for 45 days. The dosing will depend on a creatinine clearance at screening.

Placebo Comparator: Placebo - Each patient will receive matching placebo tablet once daily orally (by mouth) for 45 days.


Treatment: Drugs: Rivaroxaban, 10 mg
Patients, randomly allocated to the rivaroxaban arm, with a creatinine clearance at screening greater than or equal to (>=)50 mL/min will receive 10 mg rivaroxaban tablet with or without food.

Treatment: Drugs: Rivaroxaban, 7.5 mg
Patients, randomly allocated to the rivaroxaban arm, with a creatinine clearance at screening from >=30 to less than (<)50 mL/min will receive 7.5 mg rivaroxaban tablet with or without food.

Treatment: Drugs: Placebo
All patients, randomly allocated to the placebo arm, will receive one placebo tablet with or without food.

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Time From Randomization to First Occurrence of Composite of All Symptomatic Venous Thromboembolism (VTE) and VTE Related Death Adjudicated by Clinical Event Committee (CEC) - Symptomatic VTE included lower extremity deep vein thrombosis (DVT) and non-fatal pulmonary embolism (PE). Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
Timepoint [1] 0 0
Up to Day 45
Primary outcome [2] 0 0
Event Rate Based on Time From Randomization to the First Occurrence of Major Bleeding Adjudicated by CEC - A major bleeding event was defined using validated International Society on Thrombosis and Haemostasis (ISTH) bleeding criteria. A major bleeding event was defined as overt bleeding that was associated with a fall in hemoglobin of 2 gram per deciliter (g/dL) or more, or a transfusion of 2 or more units of packed red blood cells or whole blood, or a critical site defined as intracranial, intraspinal, intraocular, pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal, or a fatal outcome. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or last dose + 2 days.
Timepoint [2] 0 0
From randomization to 2 days after the last dose (Day 45)
Secondary outcome [1] 0 0
Event Rate Based on Time From Randomization to First Occurrence of VTE-Related Death Adjudicated by CEC - Event rate based on time from randomization to first occurrence of VTE-related death (adjudicated by CEC) was assessed. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
Timepoint [1] 0 0
Up to Day 45
Secondary outcome [2] 0 0
Event Rate Based on Time From Randomization to the First Occurrence of a Symptomatic Venous Thromboembolism Event (VTE) Adjudicated by CEC - Event rate based on time from randomization to the first occurrence of a symptomatic VTE (adjudicated by CEC) was assessed. Symptomatic VTE included lower extremity DVT and non-fatal PE. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
Timepoint [2] 0 0
Up to Day 45
Secondary outcome [3] 0 0
Event Rate Based on Time From Randomization to the First Occurrence of a Composite of Symptomatic VTE and All-Cause Mortality (ACM) Adjudicated by CEC - Event rate based on time from randomization to the first occurrence of a composite of symptomatic VTE and ACM (adjudicated by CEC) was assessed. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
Timepoint [3] 0 0
Up to Day 45
Secondary outcome [4] 0 0
Event Rate Based on Time From Randomization to the First Occurrence of a Composite of Symptomatic VTE, Myocardial Infarction (MI), Non-Hemorrhagic Stroke, and Cardiovascular (CV) Death Adjudicated by CEC - Event rate based on time from randomization to the first occurrence of a composite of symptomatic VTE (lower extremity DVT and non-fatal PE), MI, non-hemorrhagic stroke, and CV death (death due to a known CV cause and death in which a CV cause cannot be ruled out; by this definition, a VTE-related death was considered a CV death) as adjudicated by CEC was reported. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
Timepoint [4] 0 0
Up to Day 45
Secondary outcome [5] 0 0
Event Rate Based on Time From Randomization to First Occurrence of All-Cause Mortality (ACM) Adjudicated by CEC - Event rate based on time from randomization to first occurrence of ACM (adjudicated by CEC) was assessed. Event rate was defined as number of events per 100 participants in 45 days of follow up. Participants who did not have events were censored on the minimum of last visit before or on death, or Day 45.
Timepoint [5] 0 0
Up to Day 45

Eligibility
Key inclusion criteria
Key

- The duration of the index hospitalization must have been at least 3 and no more than
10 consecutive days

- Must meet venous thromboembolism (VTE) risk criteria with a total modified Improve VTE
Risk Score of: greater than or equal 4, or 3 with D-dimer > 2* upper limit of normal
(ULN), or 2 with D-dimer > 2*ULN

Key
Minimum age
40 Years
Maximum age
No limit
Gender
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
- Any serious bleeding within 3 months prior to randomization or occurring during index
hospitalization

- Serious trauma (including head trauma) within 4 weeks before randomization

- History of hemorrhagic stroke at any time in the past

- Any medical condition that requires chronic use of any parenteral or oral
anticoagulation

Study design
Purpose of the study
Prevention
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s

Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
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- Bedford Park
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- Box Hill
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- Chermside
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- East Saint Kilda
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- Launceston
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- Lismore
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- Redcliffe
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- South Brisbane
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- Sydney
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- VIC, Parkville
Recruitment outside Australia
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Pribram
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Slany
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Trinec
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Trutnov
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Zlin
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Hvidovre
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Denmark
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København S
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Denmark
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Roskilde
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Tallinn
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Georgia
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Georgia
State/province [182] 0 0
Kutaisi
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Georgia
State/province [183] 0 0
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Georgia
State/province [184] 0 0
Rustavi
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Georgia
State/province [185] 0 0
T'bilisi
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Georgia
State/province [186] 0 0
Tbilisi
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Georgia
State/province [187] 0 0
Telavi
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Germany
State/province [188] 0 0
Berlin
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Germany
State/province [189] 0 0
Coburg
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Germany
State/province [190] 0 0
Dresden
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Germany
State/province [191] 0 0
Esslingen
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Germany
State/province [192] 0 0
Frankfurt
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Germany
State/province [193] 0 0
Heidelberg
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Germany
State/province [194] 0 0
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Germany
State/province [195] 0 0
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Germany
State/province [196] 0 0
Leipzig
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Germany
State/province [197] 0 0
Limburg
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Germany
State/province [198] 0 0
Mannheim
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Germany
State/province [199] 0 0
Minden
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Germany
State/province [200] 0 0
Mönchengladbach
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Germany
State/province [201] 0 0
Neuwied
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Germany
State/province [202] 0 0
Troisdorf
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Germany
State/province [203] 0 0
Witten
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Greece
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Achaïa
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Greece
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Greece
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Greece
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Heraklion
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Greece
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Ioannina
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Greece
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Greece
State/province [211] 0 0
Patra
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Greece
State/province [212] 0 0
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Greece
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Greece
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Voula
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Hungary
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Ajka
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Hungary
State/province [216] 0 0
Baja
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Hungary
State/province [217] 0 0
Balassagyarmat
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Hungary
State/province [218] 0 0
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Hungary
State/province [219] 0 0
Budapest
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Hungary
State/province [220] 0 0
Cegléd
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Hungary
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Debrecen
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Hungary
State/province [222] 0 0
Eger
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Hungary
State/province [223] 0 0
Farkasgyepü
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Hungary
State/province [224] 0 0
Gyula
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Hungary
State/province [225] 0 0
Gyõr
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Hungary
State/province [226] 0 0
Gödöllo
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Hungary
State/province [227] 0 0
Hodmezovasarhely
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Hungary
State/province [228] 0 0
Kalocsa
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Hungary
State/province [229] 0 0
Kaposvar
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Hungary
State/province [230] 0 0
Kecskemet N/a
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Hungary
State/province [231] 0 0
Kecskemet
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Hungary
State/province [232] 0 0
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Hungary
State/province [233] 0 0
Kistarcsa
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Hungary
State/province [234] 0 0
Komarom
Country [235] 0 0
Hungary
State/province [235] 0 0
Miskolc
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Hungary
State/province [236] 0 0
Nagykanizsa
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Hungary
State/province [237] 0 0
Orosháza
Country [238] 0 0
Hungary
State/province [238] 0 0
Pecs
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Hungary
State/province [239] 0 0
Pécs
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Hungary
State/province [240] 0 0
Szeged
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Hungary
State/province [241] 0 0
Szekesfehervar
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Hungary
State/province [242] 0 0
Szekszárd
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Hungary
State/province [243] 0 0
Szentes
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Hungary
State/province [244] 0 0
Szolnok
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Hungary
State/province [245] 0 0
Szombathely
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Hungary
State/province [246] 0 0
Székesfehérvár
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Hungary
State/province [247] 0 0
Sátoraljaújhely
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Hungary
State/province [248] 0 0
Zalaegerszeg
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Israel
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Israel
State/province [250] 0 0
Hadera
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Israel
State/province [251] 0 0
Haifa
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Israel
State/province [252] 0 0
Holon
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Israel
State/province [253] 0 0
Jerusalem
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Israel
State/province [254] 0 0
Kfar-Saba
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Israel
State/province [255] 0 0
Modi'in
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Israel
State/province [256] 0 0
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Israel
State/province [257] 0 0
Petah Tikva
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Israel
State/province [258] 0 0
Petah Tiqwa
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Israel
State/province [259] 0 0
Rehovot
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Israel
State/province [260] 0 0
Safed
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Israel
State/province [261] 0 0
Tel-Hashomer
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Israel
State/province [262] 0 0
Tiberias
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Israel
State/province [263] 0 0
Zefat
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Latvia
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Balvi
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State/province [265] 0 0
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Latvia
State/province [266] 0 0
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Latvia
State/province [267] 0 0
Jelgava
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Latvia
State/province [268] 0 0
Kraslavas Aprinkis
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Latvia
State/province [269] 0 0
Kuldiga
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Latvia
State/province [270] 0 0
Liepaja
Country [271] 0 0
Latvia
State/province [271] 0 0
Riga
Country [272] 0 0
Latvia
State/province [272] 0 0
Ventspils
Country [273] 0 0
Lithuania
State/province [273] 0 0
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Lithuania
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Klaipeda
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Lithuania
State/province [275] 0 0
Panevezys
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Lithuania
State/province [276] 0 0
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Lithuania
State/province [277] 0 0
Taurage
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Lithuania
State/province [278] 0 0
Utena
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Lithuania
State/province [279] 0 0
Vilniaus Apskritis
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Lithuania
State/province [280] 0 0
Vilnius
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Mexico
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Aguascalientes
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Mexico
State/province [282] 0 0
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Mexico
State/province [283] 0 0
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Mexico
State/province [284] 0 0
Merida
Country [285] 0 0
Mexico
State/province [285] 0 0
Monterrey
Country [286] 0 0
Mexico
State/province [286] 0 0
San Pedro Garza Garcia
Country [287] 0 0
Netherlands
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Alkmaar
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Netherlands
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Almelo
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Netherlands
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Amsterdam
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Netherlands
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Arnhem
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Netherlands
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Den Haag
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Netherlands
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Harderwijk
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Netherlands
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Netherlands
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Hoorn
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Netherlands
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Maastricht
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Netherlands
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Nieuwegein
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Netherlands
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s-Hertogenbosch
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Netherlands
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Sittard-Geleen
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Netherlands
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Sneek
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Netherlands
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Tilburg
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Netherlands
State/province [301] 0 0
Veldhoven
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Netherlands
State/province [302] 0 0
Zutphen
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Netherlands
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Zwolle
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North Macedonia
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Bitola
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North Macedonia
State/province [305] 0 0
Ohrid
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North Macedonia
State/province [306] 0 0
Skopje
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North Macedonia
State/province [307] 0 0
Struga
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North Macedonia
State/province [308] 0 0
Štip
Country [309] 0 0
Peru
State/province [309] 0 0
Callao
Country [310] 0 0
Peru
State/province [310] 0 0
Lima
Country [311] 0 0
Poland
State/province [311] 0 0
Bialystok
Country [312] 0 0
Poland
State/province [312] 0 0
Bielsko-Biala
Country [313] 0 0
Poland
State/province [313] 0 0
Bydgoszcz
Country [314] 0 0
Poland
State/province [314] 0 0
Bystra
Country [315] 0 0
Poland
State/province [315] 0 0
Czeladz
Country [316] 0 0
Poland
State/province [316] 0 0
Gdynia
Country [317] 0 0
Poland
State/province [317] 0 0
Kielce
Country [318] 0 0
Poland
State/province [318] 0 0
Klodzko
Country [319] 0 0
Poland
State/province [319] 0 0
Krakow
Country [320] 0 0
Poland
State/province [320] 0 0
Kraków
Country [321] 0 0
Poland
State/province [321] 0 0
Leczna
Country [322] 0 0
Poland
State/province [322] 0 0
Lodz
Country [323] 0 0
Poland
State/province [323] 0 0
Lublin
Country [324] 0 0
Poland
State/province [324] 0 0
Olawa
Country [325] 0 0
Poland
State/province [325] 0 0
Ostroleka
Country [326] 0 0
Poland
State/province [326] 0 0
Ostrow Mazowiecka
Country [327] 0 0
Poland
State/province [327] 0 0
Pabianice
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Poland
State/province [328] 0 0
Plock
Country [329] 0 0
Poland
State/province [329] 0 0
Poznan
Country [330] 0 0
Poland
State/province [330] 0 0
Proszowice
Country [331] 0 0
Poland
State/province [331] 0 0
Pulawy
Country [332] 0 0
Poland
State/province [332] 0 0
Rabka-Zdroj
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Poland
State/province [333] 0 0
Siedlce
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Poland
State/province [334] 0 0
Sopot,Gdynia
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Poland
State/province [335] 0 0
Sosnowiec
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Poland
State/province [336] 0 0
Szczecin
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Poland
State/province [337] 0 0
Tarn W N/a
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Poland
State/province [338] 0 0
Torun
Country [339] 0 0
Poland
State/province [339] 0 0
Warszawa N/a
Country [340] 0 0
Poland
State/province [340] 0 0
Warszawa
Country [341] 0 0
Poland
State/province [341] 0 0
Wegrow
Country [342] 0 0
Poland
State/province [342] 0 0
Wroclaw
Country [343] 0 0
Portugal
State/province [343] 0 0
Braga
Country [344] 0 0
Portugal
State/province [344] 0 0
Coimbra
Country [345] 0 0
Portugal
State/province [345] 0 0
Covilhã
Country [346] 0 0
Portugal
State/province [346] 0 0
Figueira da Foz
Country [347] 0 0
Portugal
State/province [347] 0 0
Guimarães
Country [348] 0 0
Portugal
State/province [348] 0 0
Lisboa
Country [349] 0 0
Portugal
State/province [349] 0 0
Porto
Country [350] 0 0
Portugal
State/province [350] 0 0
Vila Nova de Gaia
Country [351] 0 0
Puerto Rico
State/province [351] 0 0
San Juan
Country [352] 0 0
Romania
State/province [352] 0 0
Bacau
Country [353] 0 0
Romania
State/province [353] 0 0
Baia Mare
Country [354] 0 0
Romania
State/province [354] 0 0
Braila
Country [355] 0 0
Romania
State/province [355] 0 0
Brasov
Country [356] 0 0
Romania
State/province [356] 0 0
Bucuresti
Country [357] 0 0
Romania
State/province [357] 0 0
Cluj-Napoca
Country [358] 0 0
Romania
State/province [358] 0 0
Craiova
Country [359] 0 0
Romania
State/province [359] 0 0
Focsani
Country [360] 0 0
Romania
State/province [360] 0 0
Iasi
Country [361] 0 0
Romania
State/province [361] 0 0
Oradea
Country [362] 0 0
Romania
State/province [362] 0 0
Pitesti
Country [363] 0 0
Romania
State/province [363] 0 0
Tg Mures
Country [364] 0 0
Romania
State/province [364] 0 0
Timisoara
Country [365] 0 0
Russian Federation
State/province [365] 0 0
Arkhangelsk
Country [366] 0 0
Russian Federation
State/province [366] 0 0
Chelyabinsk
Country [367] 0 0
Russian Federation
State/province [367] 0 0
Ekaterinburg
Country [368] 0 0
Russian Federation
State/province [368] 0 0
Irkutsk
Country [369] 0 0
Russian Federation
State/province [369] 0 0
Kazan
Country [370] 0 0
Russian Federation
State/province [370] 0 0
Kemerovo
Country [371] 0 0
Russian Federation
State/province [371] 0 0
Krasnodar
Country [372] 0 0
Russian Federation
State/province [372] 0 0
Krasnoyarsk
Country [373] 0 0
Russian Federation
State/province [373] 0 0
Moscow
Country [374] 0 0
Russian Federation
State/province [374] 0 0
Moskva
Country [375] 0 0
Russian Federation
State/province [375] 0 0
Novosibirsk
Country [376] 0 0
Russian Federation
State/province [376] 0 0
Orenburg
Country [377] 0 0
Russian Federation
State/province [377] 0 0
Penza
Country [378] 0 0
Russian Federation
State/province [378] 0 0
Rostov on Don
Country [379] 0 0
Russian Federation
State/province [379] 0 0
Saint Petersburg
Country [380] 0 0
Russian Federation
State/province [380] 0 0
Saint-Petersburg
Country [381] 0 0
Russian Federation
State/province [381] 0 0
Saratov
Country [382] 0 0
Russian Federation
State/province [382] 0 0
Smolensk
Country [383] 0 0
Russian Federation
State/province [383] 0 0
St. Petersburg
Country [384] 0 0
Russian Federation
State/province [384] 0 0
Tomsk
Country [385] 0 0
Russian Federation
State/province [385] 0 0
Ulyanovsk
Country [386] 0 0
Russian Federation
State/province [386] 0 0
Vsevolzhsk
Country [387] 0 0
Russian Federation
State/province [387] 0 0
Yaroslavl
Country [388] 0 0
Serbia
State/province [388] 0 0
Belgrade
Country [389] 0 0
Serbia
State/province [389] 0 0
Beograd
Country [390] 0 0
Serbia
State/province [390] 0 0
Cacak
Country [391] 0 0
Serbia
State/province [391] 0 0
Cuprija
Country [392] 0 0
Serbia
State/province [392] 0 0
Dedinje
Country [393] 0 0
Serbia
State/province [393] 0 0
Kragujevac
Country [394] 0 0
Serbia
State/province [394] 0 0
Leskovac
Country [395] 0 0
Serbia
State/province [395] 0 0
Nis
Country [396] 0 0
Serbia
State/province [396] 0 0
Novi Sad
Country [397] 0 0
Serbia
State/province [397] 0 0
Sabac
Country [398] 0 0
Serbia
State/province [398] 0 0
Smederevo
Country [399] 0 0
Serbia
State/province [399] 0 0
Sremska Kamenica
Country [400] 0 0
Serbia
State/province [400] 0 0
Subotica
Country [401] 0 0
Serbia
State/province [401] 0 0
Valjevo
Country [402] 0 0
Serbia
State/province [402] 0 0
Vranje
Country [403] 0 0
Serbia
State/province [403] 0 0
Zajecar
Country [404] 0 0
Slovakia
State/province [404] 0 0
Kosice
Country [405] 0 0
Slovakia
State/province [405] 0 0
Martin
Country [406] 0 0
Slovakia
State/province [406] 0 0
Nitra
Country [407] 0 0
South Africa
State/province [407] 0 0
Bellville
Country [408] 0 0
South Africa
State/province [408] 0 0
Bloemfontein
Country [409] 0 0
South Africa
State/province [409] 0 0
Cape Town
Country [410] 0 0
South Africa
State/province [410] 0 0
Durban Kwa Zulu Natal
Country [411] 0 0
South Africa
State/province [411] 0 0
Durban
Country [412] 0 0
South Africa
State/province [412] 0 0
Gatesville Cape Town
Country [413] 0 0
South Africa
State/province [413] 0 0
Groenkloof, Pretoria
Country [414] 0 0
South Africa
State/province [414] 0 0
Johannesburg
Country [415] 0 0
South Africa
State/province [415] 0 0
Kempton Park
Country [416] 0 0
South Africa
State/province [416] 0 0
Kuils River
Country [417] 0 0
South Africa
State/province [417] 0 0
Pretoria
Country [418] 0 0
South Africa
State/province [418] 0 0
Somerset West
Country [419] 0 0
South Africa
State/province [419] 0 0
Stellenbosch
Country [420] 0 0
South Africa
State/province [420] 0 0
Worcester
Country [421] 0 0
Spain
State/province [421] 0 0
Alcalá de Henares
Country [422] 0 0
Spain
State/province [422] 0 0
Alicante
Country [423] 0 0
Spain
State/province [423] 0 0
Almeria
Country [424] 0 0
Spain
State/province [424] 0 0
Alzira
Country [425] 0 0
Spain
State/province [425] 0 0
Aranjuez
Country [426] 0 0
Spain
State/province [426] 0 0
Avila
Country [427] 0 0
Spain
State/province [427] 0 0
Balea
Country [428] 0 0
Spain
State/province [428] 0 0
Barcelona
Country [429] 0 0
Spain
State/province [429] 0 0
Burgos
Country [430] 0 0
Spain
State/province [430] 0 0
Cartagena
Country [431] 0 0
Spain
State/province [431] 0 0
Cáceres
Country [432] 0 0
Spain
State/province [432] 0 0
Don Benito
Country [433] 0 0
Spain
State/province [433] 0 0
Elche
Country [434] 0 0
Spain
State/province [434] 0 0
Getafe
Country [435] 0 0
Spain
State/province [435] 0 0
Granada
Country [436] 0 0
Spain
State/province [436] 0 0
Huelva N/a
Country [437] 0 0
Spain
State/province [437] 0 0
La Laguna
Country [438] 0 0
Spain
State/province [438] 0 0
Las Palmas de Gran Canaria
Country [439] 0 0
Spain
State/province [439] 0 0
Logroño
Country [440] 0 0
Spain
State/province [440] 0 0
Madrid
Country [441] 0 0
Spain
State/province [441] 0 0
Majadahonda-Madrid
Country [442] 0 0
Spain
State/province [442] 0 0
Malaga
Country [443] 0 0
Spain
State/province [443] 0 0
Murcia
Country [444] 0 0
Spain
State/province [444] 0 0
Móstoles