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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/ct2/show/NCT01225562




Registration number
NCT01225562
Ethics application status
Date submitted
9/07/2010
Date registered
21/10/2010
Date last updated
25/01/2016

Titles & IDs
Public title
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
Scientific title
A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myocardial Infarction
Secondary ID [1] 0 0
2009-017242-30
Secondary ID [2] 0 0
D5132C00001
Universal Trial Number (UTN)
Trial acronym
PEGASUS
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Myocardial Infarction 0 0
Cardiovascular Death 0 0
Atherothrombosis 0 0
Stroke 0 0
Condition category
Condition code
Cardiovascular 0 0 0 0
Coronary heart disease
Cardiovascular 0 0 0 0
Other cardiovascular diseases
Cardiovascular 0 0 0 0
Diseases of the vasculature and circulation including the lymphatic system
Blood 0 0 0 0
Clotting disorders

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Ticagrelor 90 mg
Treatment: Drugs - Ticagrelor 60 mg
Treatment: Drugs - Ticagrelor Placebo

Experimental: 1 - Oral Treatment

Experimental: 2 - Oral Treatment

Placebo Comparator: 3 - Oral Treatment


Treatment: Drugs: Ticagrelor 90 mg
Oral dose twice a day

Treatment: Drugs: Ticagrelor 60 mg
Oral dose twice a day

Treatment: Drugs: Ticagrelor Placebo
Oral dose twice a day
Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization
Timepoint [1] 0 0
Randomization up to 47 months
Primary outcome [2] 0 0
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients
Timepoint [2] 0 0
First dosing up to 48 months
Secondary outcome [1] 0 0
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization
Timepoint [1] 0 0
Randomization up to 47 months
Secondary outcome [2] 0 0
Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization
Timepoint [2] 0 0
Randomization up to 47 months

Eligibility
Key inclusion criteria
- Person who had a heart attack within 1 - 3 years ago and at least one additional risk
factor: Age = 65 years old, Diabetes requiring medication, Documented history of 2nd
prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic,
non-end stage renal dysfunction.

- Females of child-bearing potential must have a negative pregnancy test at enrollment

- Persons who are currently taking aspirin between 75 and 150 mg once daily
Minimum age
50 Years
Maximum age
130 Years
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
- Persons who are being treated with agents inhibiting blood clotting if the agent
cannot be stopped at study start

- Persons who have planned coronary, cerebrovascular, or peripheral arterial
Revascularization (invasive surgery) at study start

- Persons with known bleeding disorders

- Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight
heparin

- Persons with a history of ischemic stroke

- Persons with a history of intracranial bleeding at any time, a tumor or blood vessel
abnormality in the brain and/or spinal cord at any time, a history of surgery
involving the brain or spinal cord within the last 5 years, or a history of bleeding
from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the
last 6 months or a major surgery within the last 30 days.

- Persons considered to be at risk of bradycardic events unless already treated with a
permanent pacemaker

- Persons who have had open heart surgery within the past 5 years, unless the person had
a heart attack after the surgery

- Persons with known severe liver disease

- Persons with kidney failure requiring dialysis

- Persons with life expectancy < 1 year

Study design
Purpose of the study
Prevention
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
1/10/2010
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
1/12/2014
Sample size
Target
Accrual to date
Final
21379
Recruitment in Australia
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Country [191] 0 0
Czech Republic
State/province [191] 0 0
Usti nad Orlici
Country [192] 0 0
Czech Republic
State/province [192] 0 0
Znojmo
Country [193] 0 0
France
State/province [193] 0 0
ABBEVILLE cedex
Country [194] 0 0
France
State/province [194] 0 0
Albi
Country [195] 0 0
France
State/province [195] 0 0
ANGERS Cedex 9
Country [196] 0 0
France
State/province [196] 0 0
Angers
Country [197] 0 0
France
State/province [197] 0 0
Avignon Cedex
Country [198] 0 0
France
State/province [198] 0 0
Bayonne
Country [199] 0 0
France
State/province [199] 0 0
Cannes
Country [200] 0 0
France
State/province [200] 0 0
Creteil
Country [201] 0 0
France
State/province [201] 0 0
Dijon
Country [202] 0 0
France
State/province [202] 0 0
Jossigny
Country [203] 0 0
France
State/province [203] 0 0
La Rochelle Cedex
Country [204] 0 0
France
State/province [204] 0 0
Le Chesnay
Country [205] 0 0
France
State/province [205] 0 0
Le Coudray Cedex
Country [206] 0 0
France
State/province [206] 0 0
Limoges Cedex
Country [207] 0 0
France
State/province [207] 0 0
MARSEILLE Cedex 5
Country [208] 0 0
France
State/province [208] 0 0
Metz Cedex 1
Country [209] 0 0
France
State/province [209] 0 0
NICE Cedex 01
Country [210] 0 0
France
State/province [210] 0 0
NIMES Cedex 9
Country [211] 0 0
France
State/province [211] 0 0
Orléans Cedex 2
Country [212] 0 0
France
State/province [212] 0 0
Paris
Country [213] 0 0
France
State/province [213] 0 0
Pessac
Country [214] 0 0
France
State/province [214] 0 0
Poitiers
Country [215] 0 0
France
State/province [215] 0 0
Toulouse Cedex
Country [216] 0 0
France
State/province [216] 0 0
TOURCOING cedex
Country [217] 0 0
Germany
State/province [217] 0 0
Bad Krozingen
Country [218] 0 0
Germany
State/province [218] 0 0
Bad Mergentheim
Country [219] 0 0
Germany
State/province [219] 0 0
Bad Nauheim
Country [220] 0 0
Germany
State/province [220] 0 0
Berlin
Country [221] 0 0
Germany
State/province [221] 0 0
Bielefeld
Country [222] 0 0
Germany
State/province [222] 0 0
Coburg
Country [223] 0 0
Germany
State/province [223] 0 0
Deggingen
Country [224] 0 0
Germany
State/province [224] 0 0
Dortmund
Country [225] 0 0
Germany
State/province [225] 0 0
Dresden
Country [226] 0 0
Germany
State/province [226] 0 0
Essen
Country [227] 0 0
Germany
State/province [227] 0 0
Esslingen
Country [228] 0 0
Germany
State/province [228] 0 0
Frankfurt
Country [229] 0 0
Germany
State/province [229] 0 0
Hamburg
Country [230] 0 0
Germany
State/province [230] 0 0
Heidelberg
Country [231] 0 0
Germany
State/province [231] 0 0
Kassel
Country [232] 0 0
Germany
State/province [232] 0 0
Kiel
Country [233] 0 0
Germany
State/province [233] 0 0
Leipzig
Country [234] 0 0
Germany
State/province [234] 0 0
Limburg
Country [235] 0 0
Germany
State/province [235] 0 0
Ludwigshafen
Country [236] 0 0
Germany
State/province [236] 0 0
Lübeck
Country [237] 0 0
Germany
State/province [237] 0 0
Mainz
Country [238] 0 0
Germany
State/province [238] 0 0
Mönchengladbach
Country [239] 0 0
Germany
State/province [239] 0 0
Ulm
Country [240] 0 0
Germany
State/province [240] 0 0
Warendorf
Country [241] 0 0
Germany
State/province [241] 0 0
Witten
Country [242] 0 0
Hungary
State/province [242] 0 0
Ballasagyarmat
Country [243] 0 0
Hungary
State/province [243] 0 0
Budapest
Country [244] 0 0
Hungary
State/province [244] 0 0
Békéscsaba
Country [245] 0 0
Hungary
State/province [245] 0 0
Cegléd
Country [246] 0 0
Hungary
State/province [246] 0 0
Debrecen
Country [247] 0 0
Hungary
State/province [247] 0 0
Eger
Country [248] 0 0
Hungary
State/province [248] 0 0
Gyula
Country [249] 0 0
Hungary
State/province [249] 0 0
Kalocsa
Country [250] 0 0
Hungary
State/province [250] 0 0
Kecskemét
Country [251] 0 0
Hungary
State/province [251] 0 0
Mosonmagyaróvár
Country [252] 0 0
Hungary
State/province [252] 0 0
Nyíregyháza
Country [253] 0 0
Hungary
State/province [253] 0 0
Pécs
Country [254] 0 0
Hungary
State/province [254] 0 0
Sopron
Country [255] 0 0
Hungary
State/province [255] 0 0
Szeged
Country [256] 0 0
Hungary
State/province [256] 0 0
Szekszárd
Country [257] 0 0
Hungary
State/province [257] 0 0
Szolnok
Country [258] 0 0
Hungary
State/province [258] 0 0
Székesfehérvár
Country [259] 0 0
Hungary
State/province [259] 0 0
Zalaegerszeg
Country [260] 0 0
Italy
State/province [260] 0 0
Albano Laziale
Country [261] 0 0
Italy
State/province [261] 0 0
Bari
Country [262] 0 0
Italy
State/province [262] 0 0
Benevento
Country [263] 0 0
Italy
State/province [263] 0 0
Brescia
Country [264] 0 0
Italy
State/province [264] 0 0
Carpi
Country [265] 0 0
Italy
State/province [265] 0 0
Catania
Country [266] 0 0
Italy
State/province [266] 0 0
Genova
Country [267] 0 0
Italy
State/province [267] 0 0
Legnano
Country [268] 0 0
Italy
State/province [268] 0 0
Lucca
Country [269] 0 0
Italy
State/province [269] 0 0
Massa
Country [270] 0 0
Italy
State/province [270] 0 0
Milano
Country [271] 0 0
Italy
State/province [271] 0 0
Napoli
Country [272] 0 0
Italy
State/province [272] 0 0
Osio Sotto frazione di Zingoni
Country [273] 0 0
Italy
State/province [273] 0 0
Parma
Country [274] 0 0
Italy
State/province [274] 0 0
Pavia
Country [275] 0 0
Italy
State/province [275] 0 0
Perugia
Country [276] 0 0
Italy
State/province [276] 0 0
Pescara
Country [277] 0 0
Italy
State/province [277] 0 0
Pisa
Country [278] 0 0
Italy
State/province [278] 0 0
Reggio Emilia
Country [279] 0 0
Italy
State/province [279] 0 0
Roma
Country [280] 0 0
Italy
State/province [280] 0 0
Rozzano
Country [281] 0 0
Italy
State/province [281] 0 0
S Maria Capua Vetere
Country [282] 0 0
Italy
State/province [282] 0 0
San Remo
Country [283] 0 0
Italy
State/province [283] 0 0
Sassari
Country [284] 0 0
Italy
State/province [284] 0 0
Sessa Aurunca
Country [285] 0 0
Italy
State/province [285] 0 0
Siena
Country [286] 0 0
Italy
State/province [286] 0 0
Sorrento NA
Country [287] 0 0
Italy
State/province [287] 0 0
Vimercate
Country [288] 0 0
Japan
State/province [288] 0 0
Akishima-shi
Country [289] 0 0
Japan
State/province [289] 0 0
Amagasaki-shi
Country [290] 0 0
Japan
State/province [290] 0 0
Beppu-shi
Country [291] 0 0
Japan
State/province [291] 0 0
Chuo-ku
Country [292] 0 0
Japan
State/province [292] 0 0
Daito-shi
Country [293] 0 0
Japan
State/province [293] 0 0
Fukui-shi
Country [294] 0 0
Japan
State/province [294] 0 0
Funabashi-shi
Country [295] 0 0
Japan
State/province [295] 0 0
Gifu-shi
Country [296] 0 0
Japan
State/province [296] 0 0
Hamamatsu-shi
Country [297] 0 0
Japan
State/province [297] 0 0
Himeji-shi
Country [298] 0 0
Japan
State/province [298] 0 0
Imabari-shi
Country [299] 0 0
Japan
State/province [299] 0 0
Isehara-shi
Country [300] 0 0
Japan
State/province [300] 0 0
Kamogawa-shi
Country [301] 0 0
Japan
State/province [301] 0 0
Kanazawa-shi
Country [302] 0 0
Japan
State/province [302] 0 0
Kawachinagano-shi
Country [303] 0 0
Japan
State/province [303] 0 0
Kisarazu-shi
Country [304] 0 0
Japan
State/province [304] 0 0
Komatsushima-shi
Country [305] 0 0
Japan
State/province [305] 0 0
Koriyama-shi
Country [306] 0 0
Japan
State/province [306] 0 0
Kumamoto-shi
Country [307] 0 0
Japan
State/province [307] 0 0
Kure-shi
Country [308] 0 0
Japan
State/province [308] 0 0
Kusatsu-shi
Country [309] 0 0
Japan
State/province [309] 0 0
Kyoto-shi
Country [310] 0 0
Japan
State/province [310] 0 0
Maebashi-shi
Country [311] 0 0
Japan
State/province [311] 0 0
Matsue-shi
Country [312] 0 0
Japan
State/province [312] 0 0
Matsumoto-shi
Country [313] 0 0
Japan
State/province [313] 0 0
Matsuyama-shi
Country [314] 0 0
Japan
State/province [314] 0 0
Meguro-ku
Country [315] 0 0
Japan
State/province [315] 0 0
Miyazaki-shi
Country [316] 0 0
Japan
State/province [316] 0 0
Osaka-shi
Country [317] 0 0
Japan
State/province [317] 0 0
Saga-shi
Country [318] 0 0
Japan
State/province [318] 0 0
Sagamihara-shi
Country [319] 0 0
Japan
State/province [319] 0 0
Saitama-shi
Country [320] 0 0
Japan
State/province [320] 0 0
Sakai-shi
Country [321] 0 0
Japan
State/province [321] 0 0
Sakaide-shi
Country [322] 0 0
Japan
State/province [322] 0 0
Sapporo-shi
Country [323] 0 0
Japan
State/province [323] 0 0
Sayama-shi
Country [324] 0 0
Japan
State/province [324] 0 0
Shimada-shi
Country [325] 0 0
Japan
State/province [325] 0 0
Shinagawa-ku
Country [326] 0 0
Japan
State/province [326] 0 0
Shizuoka-shi
Country [327] 0 0
Japan
State/province [327] 0 0
Suwa-shi
Country [328] 0 0
Japan
State/province [328] 0 0
Takarazuka-shi
Country [329] 0 0
Japan
State/province [329] 0 0
Takasaki-shi
Country [330] 0 0
Japan
State/province [330] 0 0
Takatsuki-shi
Country [331] 0 0
Japan
State/province [331] 0 0
Tomakomai-shi
Country [332] 0 0
Japan
State/province [332] 0 0
Toyonaka-shi
Country [333] 0 0
Japan
State/province [333] 0 0
Ueda-shi
Country [334] 0 0
Japan
State/province [334] 0 0
Wakayama-shi
Country [335] 0 0
Japan
State/province [335] 0 0
Wako-shi
Country [336] 0 0
Japan
State/province [336] 0 0
Yatsushiro-shi
Country [337] 0 0
Japan
State/province [337] 0 0
Yokohama-shi
Country [338] 0 0
Korea, Republic of
State/province [338] 0 0
Bucheon-si
Country [339] 0 0
Korea, Republic of
State/province [339] 0 0
Busan
Country [340] 0 0
Korea, Republic of
State/province [340] 0 0
Cheongju
Country [341] 0 0
Korea, Republic of
State/province [341] 0 0
Daegu
Country [342] 0 0
Korea, Republic of
State/province [342] 0 0
Daejeon
Country [343] 0 0
Korea, Republic of
State/province [343] 0 0
Gwangju
Country [344] 0 0
Korea, Republic of
State/province [344] 0 0
Jeonju
Country [345] 0 0
Korea, Republic of
State/province [345] 0 0
Seongnam-si
Country [346] 0 0
Korea, Republic of
State/province [346] 0 0
Seoul
Country [347] 0 0
Korea, Republic of
State/province [347] 0 0
Suwon-si
Country [348] 0 0
Korea, Republic of
State/province [348] 0 0
Uijeongbu
Country [349] 0 0
Korea, Republic of
State/province [349] 0 0
Wonju-si
Country [350] 0 0
Netherlands
State/province [350] 0 0
Almere
Country [351] 0 0
Netherlands
State/province [351] 0 0
Amersfoort
Country [352] 0 0
Netherlands
State/province [352] 0 0
Amsterdam
Country [353] 0 0
Netherlands
State/province [353] 0 0
Arnhem
Country [354] 0 0
Netherlands
State/province [354] 0 0
Beverwijk
Country [355] 0 0
Netherlands
State/province [355] 0 0
Breda
Country [356] 0 0
Netherlands
State/province [356] 0 0
Delft
Country [357] 0 0
Netherlands
State/province [357] 0 0
Den Haag
Country [358] 0 0
Netherlands
State/province [358] 0 0
Den Helder
Country [359] 0 0
Netherlands
State/province [359] 0 0
Deventer
Country [360] 0 0
Netherlands
State/province [360] 0 0
Drachten
Country [361] 0 0
Netherlands
State/province [361] 0 0
EDE
Country [362] 0 0
Netherlands
State/province [362] 0 0
Eindhoven
Country [363] 0 0
Netherlands
State/province [363] 0 0
Goes
Country [364] 0 0
Netherlands
State/province [364] 0 0
Groningen
Country [365] 0 0
Netherlands
State/province [365] 0 0
Hardenberg
Country [366] 0 0
Netherlands
State/province [366] 0 0
Heerenveen
Country [367] 0 0
Netherlands
State/province [367] 0 0
Heerlen
Country [368] 0 0
Netherlands
State/province [368] 0 0
Helmond
Country [369] 0 0
Netherlands
State/province [369] 0 0
Hilversum
Country [370] 0 0
Netherlands
State/province [370] 0 0
Hoofddorp
Country [371] 0 0
Netherlands
State/province [371] 0 0
Hoogeveen
Country [372] 0 0
Netherlands
State/province [372] 0 0
Leiderdorp
Country [373] 0 0
Netherlands
State/province [373] 0 0
Maastricht
Country [374] 0 0
Netherlands
State/province [374] 0 0
Nieuwegein
Country [375] 0 0
Netherlands
State/province [375] 0 0
Nijmegen
Country [376] 0 0
Netherlands
State/province [376] 0 0
OSS
Country [377] 0 0
Netherlands
State/province [377] 0 0
Roosendaal
Country [378] 0 0
Netherlands
State/province [378] 0 0
Rotterdam
Country [379] 0 0
Netherlands
State/province [379] 0 0
Schiedam
Country [380] 0 0
Netherlands
State/province [380] 0 0
Shertogenbosch
Country [381] 0 0
Netherlands
State/province [381] 0 0
Sittardgeleen
Country [382] 0 0
Netherlands
State/province [382] 0 0
Sneek
Country [383] 0 0
Netherlands
State/province [383] 0 0
Tiel
Country [384] 0 0
Netherlands
State/province [384] 0 0
Tilburg
Country [385] 0 0
Netherlands
State/province [385] 0 0
Veldhoven
Country [386] 0 0
Norway
State/province [386] 0 0
Bergen
Country [387] 0 0
Norway
State/province [387] 0 0
Bodo
Country [388] 0 0
Norway
State/province [388] 0 0
Bodø
Country [389] 0 0
Norway
State/province [389] 0 0
Flekkefjord
Country [390] 0 0
Norway
State/province [390] 0 0
Hamar
Country [391] 0 0
Norway
State/province [391] 0 0
Levanger
Country [392] 0 0
Norway
State/province [392] 0 0
Lillehammer
Country [393] 0 0
Norway
State/province [393] 0 0
Nesttun
Country [394] 0 0
Norway
State/province [394] 0 0
Oslo
Country [395] 0 0
Norway
State/province [395] 0 0
Skien
Country [396] 0 0
Norway
State/province [396] 0 0
Tromsø
Country [397] 0 0
Norway
State/province [397] 0 0
Tynset
Country [398] 0 0
Peru
State/province [398] 0 0
Arequipa
Country [399] 0 0
Peru
State/province [399] 0 0
Callao
Country [400] 0 0
Peru
State/province [400] 0 0
Lima
Country [401] 0 0
Peru
State/province [401] 0 0
San Borja
Country [402] 0 0
Peru
State/province [402] 0 0
Trujillo
Country [403] 0 0
Philippines
State/province [403] 0 0
Cebu City
Country [404] 0 0
Philippines
State/province [404] 0 0
Fuente Osmena Cebu City
Country [405] 0 0
Philippines
State/province [405] 0 0
Iloilo City
Country [406] 0 0
Philippines
State/province [406] 0 0
Las Pinas City
Country [407] 0 0
Philippines
State/province [407] 0 0
Lipa City
Country [408] 0 0
Philippines
State/province [408] 0 0
Mandaluyong City
Country [409] 0 0
Philippines
State/province [409] 0 0
Manila
Country [410] 0 0
Philippines
State/province [410] 0 0
Pasig City
Country [411] 0 0
Philippines
State/province [411] 0 0
Quezon City
Country [412] 0 0
Philippines
State/province [412] 0 0
Quezon
Country [413] 0 0
Philippines
State/province [413] 0 0
San Juan
Country [414] 0 0
Poland
State/province [414] 0 0
Bialystok
Country [415] 0 0
Poland
State/province [415] 0 0
Bielsko Biala
Country [416] 0 0
Poland
State/province [416] 0 0
Bydgoszcz
Country [417] 0 0
Poland
State/province [417] 0 0
Chorzow
Country [418] 0 0
Poland
State/province [418] 0 0
Gdansk
Country [419] 0 0
Poland
State/province [419] 0 0
Gdynia
Country [420] 0 0
Poland
State/province [420] 0 0
Gizycko
Country [421] 0 0
Poland
State/province [421] 0 0
Kraków
Country [422] 0 0
Poland
State/province [422] 0 0
Legnica
Country [423] 0 0
Poland
State/province [423] 0 0
Lubin
Country [424] 0 0
Poland
State/province [424] 0 0
Nowa Sól
Country [425] 0 0
Poland
State/province [425] 0 0
Olsztyn
Country [426] 0 0
Poland
State/province [426] 0 0
Opole
Country [427] 0 0
Poland
State/province [427] 0 0
Ostrów Mazowiecka
Country [428] 0 0
Poland
State/province [428] 0 0
Olawa
Country [429] 0 0
Poland
State/province [429] 0 0
Piotrkow
Country [430] 0 0
Poland
State/province [430] 0 0
Poznan
Country [431] 0 0
Poland
State/province [431] 0 0
Plock
Country [432] 0 0
Poland
State/province [432] 0 0
Skierniewice
Country [433] 0 0
Poland
State/province [433] 0 0
Sobótka
Country [434] 0 0
Poland
State/province [434] 0 0
Sokolka
Country [435] 0 0
Poland
State/province [435] 0 0
Szczecin
Country [436] 0 0
Poland
State/province [436] 0 0
Tarnów
Country [437] 0 0
Poland
State/province [437] 0 0
Torun
Country [438] 0 0
Poland
State/province [438] 0 0
Warszawa
Country [439] 0 0
Poland
State/province [439] 0 0
Wroclaw
Country [440] 0 0
Poland
State/province [440] 0 0
Wloclawek
Country [441] 0 0
Poland
State/province [441] 0 0
Lancut
Country [442] 0 0
Poland
State/province [442] 0 0
Lódz
Country [443] 0 0
Poland
State/province [443] 0 0
Leczna
Country [444] 0 0
Romania
State/province [444] 0 0
Bacau
Country [445] 0 0
Romania
State/province [445] 0 0
Braila
Country [446] 0 0
Romania
State/province [446] 0 0
Brasov
Country [447] 0 0
Romania
State/province [447] 0 0
Bucharest
Country [448] 0 0
Romania
State/province [448] 0 0
Bucuresti
Country [449] 0 0
Romania
State/province [449] 0 0
Buzau
Country [450] 0 0
Romania
State/province [450] 0 0
Cluj Napoca
Country [451] 0 0
Romania
State/province [451] 0 0
Craiova
Country [452] 0 0
Romania
State/province [452] 0 0
Deva
Country [453] 0 0
Romania
State/province [453] 0 0
Focsani
Country [454] 0 0
Romania
State/province [454] 0 0
Iasi
Country [455] 0 0
Romania
State/province [455] 0 0
Pitesti
Country [456] 0 0
Romania
State/province [456] 0 0
Sibiu
Country [457] 0 0
Romania
State/province [457] 0 0
Suceava
Country [458] 0 0
Romania
State/province [458] 0 0
Tg. Mures
Country [459] 0 0
Romania
State/province [459] 0 0
Timisoara
Country [460] 0 0
Russian Federation
State/province [460] 0 0
Ekaterinburg
Country [461] 0 0
Russian Federation
State/province [461] 0 0
Gatchina
Country [462] 0 0
Russian Federation
State/province [462] 0 0
Kazan
Country [463] 0 0
Russian Federation
State/province [463] 0 0
Krasnodar
Country [464] 0 0
Russian Federation
State/province [464] 0 0
Moscow
Country [465] 0 0
Russian Federation
State/province [465] 0 0
Nizhnii Novgorod
Country [466] 0 0
Russian Federation
State/province [466] 0 0
Novosibirsk
Country [467] 0 0
Russian Federation
State/province [467] 0 0
Perm
Country [468] 0 0
Russian Federation
State/province [468] 0 0
Saint Petersburg
Country [469] 0 0
Russian Federation
State/province [469] 0 0
Saint-Petersburg
Country [470] 0 0
Russian Federation
State/province [470] 0 0
Saratov
Country [471] 0 0
Russian Federation
State/province [471] 0 0
St.-Petersburg,
Country [472] 0 0
Russian Federation
State/province [472] 0 0
St.-Petersburg
Country [473] 0 0
Russian Federation
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York

Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
Name
AstraZeneca
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
This study is being carried out to see if a new drug called ticagrelor given twice daily in
addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death
from heart disease, heart attack, or stroke).
Trial website
https://clinicaltrials.gov/ct2/show/NCT01225562
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Eugene Braunwald, MD
Address 0 0
TIMI Study Group
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries