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Trial registered on ANZCTR


Registration number
ACTRN12624000617561p
Ethics application status
Submitted, not yet approved
Date submitted
11/04/2024
Date registered
13/05/2024
Date last updated
13/05/2024
Date data sharing statement initially provided
13/05/2024
Type of registration
Prospectively registered

Titles & IDs
Public title
Comparing Isometric and Dynamic Resistance Training: Impact on Muscle Performance and Body Composition
Scientific title
Effectiveness of Isometric versus Dynamic Resistance Training on Muscle Performance and Body Composition in Healthy adults
Secondary ID [1] 311944 0
Nill
Universal Trial Number (UTN)
Trial acronym
ISO_RT
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Muscular Strength 333534 0
Muscle Mass 333535 0
Condition category
Condition code
Physical Medicine / Rehabilitation 330216 330216 0 0
Physiotherapy
Musculoskeletal 330217 330217 0 0
Normal musculoskeletal and cartilage development and function

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Isometric Resistance Training Group:

Materials: Keiser pneumatic resistance machines (Keiser Sports Health Equipment, Inc., Fresno, CA 93706, USA).

Procedures: Participants will engage in multi-joint isometric resistance training exercises targeting the chest (i.e., chest press) and leg muscles (i.e., leg press).

Delivery: Conducted in a group setting at a designated fitness facility under the supervision of researchers.

Frequency and Duration: There will be three sessions per week for a total of 12 weeks. Each session will include three sets of 6 repetitions each for the chest press and leg press exercises. Each session lasts approximately 60 minutes.

Specifics: Isometric contractions will be performed at 80% of the participant's maximal voluntary contraction (MVC). Each participant's MVC will be determined before the beginning of the trial, reassessed midway through the study, and the training load adjusted accordingly. Each set will be executed at a different angle within the normal lifting range of motion (i.e., lower third, middle third, and upper third).

Adherence/Fidelity:
Adherence will be monitored through attendance records for each session. Fidelity will be ensured through standardized protocols and regular training sessions for the intervention providers.

Location:
The study will be conducted at the Susan Wakil Health Building level 5, the University of Sydney (Camperdown).
Intervention code [1] 328401 0
Treatment: Other
Comparator / control treatment
Traditional Resistance Training Group:

Materials: Same as above.

Procedures: Participants will engage in multi-joint dynamic resistance training exercises targeting the chest (i.e., chest press) and leg (i.e., leg press) muscles.

Delivery: Conducted in a group setting at the same designated fitness facility under the supervision of researchers.

Frequency and Duration: There will be three sessions per week for a total of 12 weeks. Each session will include three sets of 6 repetitions each for the chest press and leg press exercises. Each session lasts approximately 60 minutes.

Specifics: Isotonic contractions will be performed at 80% of the participant's one-repetition maximum (1RM), with the full range of motion (ROM).
Control group
Active

Outcomes
Primary outcome [1] 337968 0
Chest Dynamic strength (1RM)
Timepoint [1] 337968 0
Baseline and 8 weeks after intervention commencement
Primary outcome [2] 337969 0
Chest Isometric strength (MVC)
Timepoint [2] 337969 0
Baseline and 8 weeks after intervention commencement
Primary outcome [3] 338104 0
Leg isometric strength (MVC)
Timepoint [3] 338104 0
Baseline and 8 weeks after intervention commencement
Secondary outcome [1] 433920 0
Chest Muscle Endurance
Timepoint [1] 433920 0
Baseline and 8 weeks after intervention commencement
Secondary outcome [2] 434733 0
Leg Muscle Endurance
Timepoint [2] 434733 0
Baseline and follow-up ( 8 weeks after intervention commencement)

Eligibility
Key inclusion criteria
1) male, 2) aged 18-45 years; 3) not engaged in structured resistance training, and 4) be apparently healthy.
Minimum age
18 Years
Maximum age
45 Years
Sex
Males
Can healthy volunteers participate?
Yes
Key exclusion criteria
1) unstable medical conditions that would preclude exercising; 2) current musculoskeletal injuries, conditions, or limitations (e.g., muscle strain/pain and joint instability) of the upper or lower body; 3) current lower back pain; and 4) inguinal, femoral, or umbilical hernia.

Study design
Purpose of the study
Educational / counselling / training
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
central randomisation by phone/fax/computer
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Simple randomisation using a randomisation table created by computer software (i.e. computerised sequence generation)
Masking / blinding
Who is / are masked / blinded?



Intervention assignment
Other design features
Phase
Not Applicable
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Not yet recruiting
Date of first participant enrolment
Anticipated
21/09/2024
Actual
Date of last participant enrolment
Anticipated
31/12/2024
Actual
Date of last data collection
Anticipated
30/04/2025
Actual
Sample size
Target
20
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
NSW

Funding & Sponsors
Funding source category [1] 316284 0
University
Name [1] 316284 0
The University of Sydney
Country [1] 316284 0
Australia
Primary sponsor type
University
Name
University of Sydney
Address
Country
Australia
Secondary sponsor category [1] 318472 0
None
Name [1] 318472 0
Address [1] 318472 0
Country [1] 318472 0

Ethics approval
Ethics application status
Submitted, not yet approved
Ethics committee name [1] 315101 0
The University of Sydney Human Research Ethics Committee
Ethics committee address [1] 315101 0
Ethics committee country [1] 315101 0
Australia
Date submitted for ethics approval [1] 315101 0
03/05/2024
Approval date [1] 315101 0
Ethics approval number [1] 315101 0

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 133682 0
Dr Daniel Hackett
Address 133682 0
Faculty of Medicine & Health, Sydney School of Health Sciences, Discipline of Exercise & Sport Science Level 6, Western Avenue, D18 - Susan Wakil Health Building | The University of Sydney | NSW | 2006
Country 133682 0
Australia
Phone 133682 0
+61 2 9351 9294
Fax 133682 0
Email 133682 0
daniel.hackett@sydney.edu.au
Contact person for public queries
Name 133683 0
Morteza Ghayomzadeh
Address 133683 0
Faculty of Medicine & Health, Sydney School of Health Sciences, Discipline of Exercise & Sport Science Level 6, Western Avenue, D18 - Susan Wakil Health Building | The University of Sydney | NSW | 2006
Country 133683 0
Australia
Phone 133683 0
+61 2 9351 9294
Fax 133683 0
Email 133683 0
m.ghayomzadehjavinani@sydney.edu.au
Contact person for scientific queries
Name 133684 0
Morteza Ghayomzadeh
Address 133684 0
Faculty of Medicine & Health, Sydney School of Health Sciences, Discipline of Exercise & Sport Science Level 6, Western Avenue, D18 - Susan Wakil Health Building | The University of Sydney | NSW | 2006
Country 133684 0
Australia
Phone 133684 0
+61 2 9351 9294
Fax 133684 0
Email 133684 0
m.ghayomzadehjavinani@sydney.edu.au

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No
No/undecided IPD sharing reason/comment


What supporting documents are/will be available?

No Supporting Document Provided



Results publications and other study-related documents

Documents added manually
No documents have been uploaded by study researchers.

Documents added automatically
No additional documents have been identified.