COVID-19 studies are our top priority. For all other trials, there is a 4-week delay in processing a trial submitted/resubmitted to the ANZCTR and additional delays for updates of registered trials. We appreciate your patience.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial registered on ANZCTR

Registration number
Ethics application status
Not yet submitted
Date submitted
Date registered
Date last updated
Type of registration
Prospectively registered

Titles & IDs
Public title
The effects of minor electrical brain stimulation on everyday attention
Scientific title
In healthy volunteers is active Transcranial Direct Current Stimulation (tDCS) better than sham stimulation at increasing scores on the Test of Everyday Attention (TEA)?
Secondary ID [1] 279709 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Everyday attention 285544 0
Condition category
Condition code
Neurological 285737 285737 0 0
Studies of the normal brain and nervous system
Mental Health 285752 285752 0 0
Studies of normal psychology, cognitive function and behaviour

Study type
Description of intervention(s) / exposure
Participants will undergo one session of Transcranial Direct Current Stimulation (tDCS). During this session, 2 mA of tDCS will be applied for 25 minutes over the right medial prefrontal cortex. Each sponge electrode will be 9 cm2. The position of the electrodes will be defined as:

Primary Electrode: We will place the primary electrode over the right mPFC as identified by the junction of FP2, FZ, and F4 electrode positions of the 10/20 EEG electrode system. 10 participants will receive positive electrode stimulation, 10 will receive negative electrode stimulation, and 10 will receive no stimulation. Participants who receive no stimulation will still have the primary electrode applied to the scalp, however, stimulation will only last for 10-seconds: just long enough to generate a slight tingle and blind the subject to his/her condition.

Secondary Electrode: We will place the secondary electrode over the left primary motor cortex (M1) as identified by the C3 electrode position of the 10/20 electrode system.
Intervention code [1] 284009 0
Other interventions
Comparator / control treatment
Sham Stimulation (same set up with no current moving between electrodes).
Control group

Primary outcome [1] 286263 0
Standardized scores on the Test of Everyday Attention (TEA).
Timepoint [1] 286263 0
Immediately following stimulation
Secondary outcome [1] 295467 0
Timepoint [1] 295467 0

Key inclusion criteria
Healthy Volunteer
Minimum age
18 Years
Maximum age
40 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
No presence of the following:
Personal history of epilepsy, head trauma, or neurological illness
History of deep brain stimulation or ablation surgery
Presence of large mass brain lesions
History of schizophrenia, schizoaffective disorder, or rapid-cycling bipolar illness
Cranial metal implants
Medical pump or cardiac pacemaker implants
Actual or possible pregnancy

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
This protocol will be double-blind. Neither the participant nor investigator will know which condition each participant is in. Although the lead investigator will set up the tDCS device, a second investigator (unblind) will actually turn on/off the device thereby leaving the lead investigator blind. A 39 number randomization list has been compiled using MatLab (to account for possible participant drop outs) and will be followed in order as subjects enroll.
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Randomized list compiled using a computer program.
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Not yet recruiting
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)

Funding & Sponsors
Funding source category [1] 284490 0
Self funded/Unfunded
Name [1] 284490 0
Address [1] 284490 0
Country [1] 284490 0
Primary sponsor type
University of Melbourne
Secondary sponsor category [1] 283416 0
Name [1] 283416 0
Address [1] 283416 0
Country [1] 283416 0

Ethics approval
Ethics application status
Not yet submitted
Ethics committee name [1] 286484 0
Ethics committee address [1] 286484 0
Ethics committee country [1] 286484 0
Date submitted for ethics approval [1] 286484 0
Approval date [1] 286484 0
Ethics approval number [1] 286484 0

Brief summary
In this study, we hope to examine tDCS effects on global arousal and attention levels. Combining evidence gathered from animal models, psychological models, pharmaceutical research, and neurostimulatory research - we hope not only to better elucidate the overall arousal/attention correlation, but also to determine if noninvasive brain-modulation can produce effects comparable to certain drug classes.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 33618 0
Address 33618 0
Country 33618 0
Phone 33618 0
Fax 33618 0
Email 33618 0
Contact person for public queries
Name 16865 0
Jared Horvath
Address 16865 0
University of Melbourne
Redmond Barry Building
Rm. 809
VIC - 3010
Country 16865 0
Phone 16865 0
+61 (0)432466963
Fax 16865 0
Email 16865 0
Contact person for scientific queries
Name 7793 0
Jared Horvath
Address 7793 0
University of Melbourne
Redmond Barry Building
Rm. 809
VIC - 3010
Country 7793 0
Phone 7793 0
+61 (0)432466963
Fax 7793 0
Email 7793 0

No information has been provided regarding IPD availability
Summary results
No Results