Trial Review

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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial registered on ANZCTR


Registration number
ACTRN12611001076965
Ethics application status
Approved
Date submitted
5/10/2011
Date registered
18/10/2011
Date last updated
17/04/2019
Date data sharing statement initially provided
17/04/2019
Type of registration
Retrospectively registered

Titles & IDs
Public title
Austalia New Zealand Acute Chest Pain (ANZACP) registry
Scientific title
Austalia New Zealand Acute Chest Pain (ANZACP) registry:
A Registry of the investigation, management and outcomes of patients presenting to two Australasian hospitals with chest pain of possible cardiac origin
Secondary ID [1] 273173 0
nil
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Chest pain of possible cardiac origin 278925 0
Condition category
Condition code
Cardiovascular 279104 279104 0 0
Coronary heart disease
Public Health 279152 279152 0 0
Health service research

Intervention/exposure
Study type
Observational
Patient registry
Target follow-up duration
Target follow-up type
Description of intervention(s) / exposure
Details of presenting complaint, past medical history, investigations, interventions and outcomes is collected in the form of a registry, and corresponding blood samples are stored for analysis of future biomarkers.
Recruitment began in November 2007 and is ongoing.
At present patient follow-up occurs up to a year after presentation.
Intervention code [1] 269504 0
Not applicable
Comparator / control treatment
n/a
Control group
Uncontrolled

Outcomes
Primary outcome [1] 279745 0
Any major adverse cardiac event (MACE) they have experienced at 30 days or 1 year
Timepoint [1] 279745 0
30 days and 1 year
Secondary outcome [1] 294356 0
To determine the diagnostic acuracy and potential cost benefit of future diagnostic strategies in terms of case weight costing and bed days.
Timepoint [1] 294356 0
From presenation to the Emergency Department at trial hospital , then at 30 days and 1 year for all cause readmission(s) and/or death.

Eligibility
Key inclusion criteria
Adults presenting to the trial hospital Emergency Department with chest pain of possible cardiac origin
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
Age < 18 years. Non-resident in country of recruitment. Patients for whom follow-up will not be possible either due to lack of onward contact address or because they will be overseas. Unable or unwilling to consent

Study design
Purpose
Screening
Duration
Longitudinal
Selection
Defined population
Timing
Prospective
Statistical methods / analysis

Recruitment
Recruitment status
Recruiting
Date of first participant enrolment
Anticipated
6/11/2007
Actual
6/11/2007
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
4000
Accrual to date
2347
Final
Recruitment in Australia
Recruitment state(s)
QLD
Recruitment outside Australia
Country [1] 3904 0
New Zealand
State/province [1] 3904 0

Funding & Sponsors
Funding source category [1] 269993 0
Government body
Name [1] 269993 0
Health Research Council New Zealand
Country [1] 269993 0
New Zealand
Funding source category [2] 269994 0
Charities/Societies/Foundations
Name [2] 269994 0
Christchurch Cardio-Endocrine Research Group
Country [2] 269994 0
New Zealand
Funding source category [3] 269995 0
Government body
Name [3] 269995 0
National Health and Medical Research Council (Australia)
Country [3] 269995 0
Australia
Funding source category [4] 270023 0
Charities/Societies/Foundations
Name [4] 270023 0
Emergency Care Foundation
Country [4] 270023 0
New Zealand
Primary sponsor type
Charities/Societies/Foundations
Name
Christchurch Cardio-Endocrine Research Group
Address
532 Seventeen Miles Rocks Rd
Sinnamon Park, QLD 4073
Country
Australia
Secondary sponsor category [1] 268978 0
Charities/Societies/Foundations
Name [1] 268978 0
Christchurch Cardio-Endocrine Research Group
Address [1] 268978 0
Department of Medicine
Christchurch Hospital
Christchurch
private bag 4710
Country [1] 268978 0
New Zealand

Ethics approval
Ethics application status
Approved
Ethics committee name [1] 271954 0
Upper South A Regional Ethics Committee
Ethics committee address [1] 271954 0
Ministry of health
PO Box 3877
Christchurch
Ethics committee country [1] 271954 0
New Zealand
Date submitted for ethics approval [1] 271954 0
Approval date [1] 271954 0
26/07/2007
Ethics approval number [1] 271954 0

Summary
Brief summary
This is a registry of patients that have presented to Australasian hospitals with chest pain of possible cardiac origin. Multiple biomarkers will be stored for ongoing research. Participants will undergo risk evaluation by a means of a set series of questions. Participants will recieve a phone call at 45 days, 6 months and 1 year post discharge to record any major adverse cardiac event (MACE) they may have experienced at 30 days or 1 year.
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 33244 0
Dr MARTIN THAN
Address 33244 0
EMERGENCY DEPARTMENT
CHRISTCHURCH HOSPITAL
1 RICCARTON AVENUE
CHRISTCHURCH 8000
Country 33244 0
New Zealand
Phone 33244 0
+6421450685
Fax 33244 0
Email 33244 0
martinthan@xtra.co.nz
Contact person for public queries
Name 16491 0
Dr Dr Martin Than
Address 16491 0
Emergency Department
Christchurch Hospital
PO Box 4710
Christchurch
Country 16491 0
New Zealand
Phone 16491 0
+643 364 0270
Fax 16491 0
+643 364 0286
Email 16491 0
martin.than@cdhb.govt.nz
Contact person for scientific queries
Name 7419 0
Dr Dr Martin Than
Address 7419 0
Emergency Department
Christchurch Hospital
PO Box 4710
Christchurch
Country 7419 0
New Zealand
Phone 7419 0
+643 364 0270
Fax 7419 0
+643 364 0286
Email 7419 0
martin.than@cdhb.govt.nz

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No/undecided IPD sharing reason/comment


What supporting documents are/will be available?

No Supporting Document Provided



Results publications and other study-related documents

Documents added manually
No documents have been uploaded by study researchers.

Documents added automatically
SourceTitleYear of PublicationDOI
EmbaseEarly kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction.2020https://dx.doi.org/10.1016/j.cca.2020.02.009
Dimensions AIDiagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain2022https://doi.org/10.1371/journal.pone.0276645
N.B. These documents automatically identified may not have been verified by the study sponsor.