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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Prospectively registered

Titles & IDs
Public title
Heritability of fat taste sensitivity and its association with obesity
Scientific title
Heritability of fat taste sensitivity in twin pairs and its association with obesity
Secondary ID [1] 253202 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Obesity 258736 0
Condition category
Condition code
Diet and Nutrition 258894 258894 0 0

Study type
Description of intervention(s) / exposure
6-week dietary intervention using a diet containing 25% energy from fat. Core foods for the diet will be delivered to the subjects. Such foods include: low fat milk and yoghurts (including frozen yoghurt), oils, low fat bran muffins and lean meats. These foods will be incorporated into the daily diet of the subjects and so they will consume these foods when they would normally have their meals and snacks. These foods will replace the higher fat alternatives in the subjects' diets.
Intervention code [1] 257681 0
Early detection / Screening
Intervention code [2] 257688 0
Other interventions
Comparator / control treatment
Control group

Primary outcome [1] 259744 0
Fat taste sensitivity as assessed by sensory measures. Subjects will be asked to complete a fat (and also salt, sour, bitter, sweet and umami) threshold assessment, hedonic ratings for selected foods and tongue photograph.
Timepoint [1] 259744 0
Baseline and 6-weeks after dietary intervention commencement
Secondary outcome [1] 266492 0
Dietary quality as assessed by 4-day diet diary.
Timepoint [1] 266492 0
Baseline and 6-weeks after dietary intervention commencement

Key inclusion criteria
Male and female mono- and di-zygotic twin pairs, aged between 18-39years, English speaking and BMI between 18-35.
Minimum age
18 Years
Maximum age
39 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
Individuals aged under 18 years or above 39 years, BMI under 18 or over 35, non-English speaking.

Study design
Purpose of the study
Allocation to intervention
Non-randomised trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Who is / are masked / blinded?

Intervention assignment
Other design features
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Not yet recruiting
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)

Funding & Sponsors
Funding source category [1] 258153 0
Self funded/Unfunded
Name [1] 258153 0
Address [1] 258153 0
Country [1] 258153 0
Primary sponsor type
Deakin University
221 Burwood Highway, Burwood, Victoria, 3125
Secondary sponsor category [1] 257317 0
Name [1] 257317 0
Address [1] 257317 0
Country [1] 257317 0
Other collaborator category [1] 251707 0
Name [1] 251707 0
Australian Twin Registry
Address [1] 251707 0
Centre for MEGA Epidemiology
School Population Health
Lvl 1, 723 Swanston St
The University of Melbourne
Victoria, Australia 3010
Country [1] 251707 0

Ethics approval
Ethics application status
Ethics committee name [1] 260129 0
Deakin University Human Ethics Office
Ethics committee address [1] 260129 0
Human Ethics Office, Research Services Division, Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125.
Ethics committee country [1] 260129 0
Date submitted for ethics approval [1] 260129 0
Approval date [1] 260129 0
Ethics approval number [1] 260129 0
EC HEAG-H153 2009

Brief summary
A recent discovery in our laboratory demonstrated that in comparison with lean subjects, the alimentary canal (oral and gastrointestinal tract) response to fats and fatty acids in foods was attenuated in overweight and obese human subjects. This data supports evidence that overweight and obese individuals consume excess dietary fat. There are two possibilities for these findings, first, that consumption of a high-fat diet induces environmental adaptive changes in the body’s sensitivity to fat, or, second, that genetic predisposition determines an individual’s fat sensitivity. Using both monozygous and dizygous twin pairs; we will estimate the magnitude of fat sensitivity heritability and its links to obesity.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 31966 0
Address 31966 0
Country 31966 0
Phone 31966 0
Fax 31966 0
Email 31966 0
Contact person for public queries
Name 15213 0
Dr Russell Keast
Address 15213 0
School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125
Country 15213 0
Phone 15213 0
+61 3 9244 6944
Fax 15213 0
Email 15213 0
Contact person for scientific queries
Name 6141 0
Dr Russell Keast
Address 6141 0
School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125
Country 6141 0
Phone 6141 0
+61 3 9244 6944
Fax 6141 0
Email 6141 0

No information has been provided regarding IPD availability
Summary results
No Results