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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT07000357




Registration number
NCT07000357
Ethics application status
Date submitted
30/05/2025
Date registered
2/06/2025
Date last updated
29/06/2025

Titles & IDs
Public title
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
Scientific title
A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Effect of AZD0780 on Major Adverse Cardiovascular Events in Patients With Established Atherosclerotic Cardiovascular Disease (ASCVD) or at High Risk for a First ASCVD Event
Secondary ID [1] 0 0
2025-520519-14
Secondary ID [2] 0 0
D7960C00015
Universal Trial Number (UTN)
Trial acronym
AZURE-Outcomes
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Cardiovascular Disease 0 0
Condition category
Condition code

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - AZD0780
Treatment: Drugs - Placebo

Experimental: AZD0780 - Participants will receive oral AZD0780 once daily

Placebo comparator: Placebo - Participants will receive oral placebo once daily


Treatment: Drugs: AZD0780
Participants will receive oral AZD0780 once daily

Treatment: Drugs: Placebo
Participants will receive oral placebo once daily
Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Time to first event of any component of MACE-PLUS
Assessment method [1] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of MACE-PLUS (the composite of CV death, myocardial infarction \[MI\], ischaemic stroke, acute lower limb ischemia, major amputation of a vascular aetiology, and urgent arterial revascularisation)
Timepoint [1] 0 0
Up to approximately 54 months
Secondary outcome [1] 0 0
Time to first event of any component of 3P MACE
Assessment method [1] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of 3-point (3P)-MACE (the composite of CV death, MI, and ischaemic stroke)
Timepoint [1] 0 0
Up to approximately 54 months
Secondary outcome [2] 0 0
Time to first event of any component of MACE PLUS
Assessment method [2] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of MACE-PLUS in patients with a history of ASCVD
Timepoint [2] 0 0
Up to approximately 54 months
Secondary outcome [3] 0 0
Time to first event of MI
Assessment method [3] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of MI
Timepoint [3] 0 0
Up to approximately 54 months
Secondary outcome [4] 0 0
Time to first event of urgent coronary revascularisation
Assessment method [4] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of urgent coronary revascularisation
Timepoint [4] 0 0
Up to approximately 54 months
Secondary outcome [5] 0 0
Time to CV death
Assessment method [5] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of CV death
Timepoint [5] 0 0
Up to approximately 54 months
Secondary outcome [6] 0 0
Time to first event of MALE
Assessment method [6] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of major adverse limb event (MALE) (the composite of acute lower limb ischemia, major amputation of vascular aetiology, and urgent lower extremity revascularisation)
Timepoint [6] 0 0
Up to approximately 54 months
Secondary outcome [7] 0 0
Time to all-cause mortality
Assessment method [7] 0 0
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of all-cause mortality
Timepoint [7] 0 0
Up to approximately 54 months

Eligibility
Key inclusion criteria
* Meets one of the following:

1. Participants with history of an ASCVD event: Participants = 18 years of age at the time of signing the ICF with a history of ASCVD defined as ACS within 1 to 12 months prior to randomisation, or large artery ischaemic stroke suspected to be due to atherosclerotic vascular disease within 1 to 12 months prior to randomisation, or revascularisation for symptomatic lower limb PAD, and LDL-C = 60 mg/dL (= 1.55 mmol/L).

Additional risk factors based on the level of the screening LDL-C:

o Participants with an LDL-C = 75 mg/dL (= 1.9 mmol/L) need to have at least one of the other additional risk factors below.
* T2DM requiring ongoing medical therapy
* Age = 65 years
* Previous above ankle amputation due to PAD
* Previous diagnosis of non-end stage CKD
2. Participants at increased risk of a first ASCVD event: Male participant = 50 years of age or female participant = 55 years of age at the time of signing the ICF with LDL-C = 100 mg/dL (= 2.6 mmol/L) and diagnostic evidence of at least one of the following disease categories (i, ii, or iii):

i) Significant atherosclerotic artery disease

ii) High-risk Type 1 or Type 2 diabetes mellitus with manifestation of end-organ disease (diabetic nephropathy, retinopathy, neuropathy or an ABI outside the normal range [0.9 to 1.4])

iii) Documented atherosclerosis of less significance

For ii) and iii), participants need to have at least one of the additional risk factors below:

1. CKD with eGFR = xx mL/min/1.73 m2
2. Current tobacco use
3. Age = 65
4. T2DM (if included on the less significant atherosclerosis criterion iii)

* Participant should be receiving a maximally tolerated lipid-lowering regimen including a maximally tolerated dose of a statin.

1. Participants who are judged by the treating physician not to tolerate high-intensity statins (according to guidelines, typically, atorvastatin = 40 mg once daily or rosuvastatin = 20 mg once daily) may be included if treated with a low or moderate intensity statin dose.
2. Participants not receiving any statins must have documented intolerable side effects to at least 2 different statins, including one at the lowest standard dose or on a chronic medication that would prohibit the use of a statin (according to the prescribing information for the statin in question).
3. Participants must achieve a stable dose (> 28 days) of lipid-lowering therapies before screening.
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
Exclusion criteria:

* Any underlying known disease, or condition including homozygous familial hypercholesterolaemia, or LDL or plasma apheresis within 12 months prior to randomisation, that, in the opinion of the investigator, might interfere with the interpretation of the clinical study results.
* Any revascularisation procedure planned within the next 3 months.
* Available imaging assessment within the last 3 years showing either coronary calcium score of zero, or a coronary computed tomography angiography with no atherosclerosis.
* Calculated eGFR < 15 mL /min/1.73 m2
* Any laboratory values with the following deviations at screening:

* AST or ALT > 3 × ULN
* TBL > 2 × ULN (except for participants with Gilbert's syndrome where TBL 3 × ULN is acceptable provided direct bilirubin < 1.5 × ULN)
* Fasting triglycerides = 400 mg/dL (= 4.52 mmol/L).
* Creatine kinase > 5 × ULN
* Urine albumin/creatinine ratio = 500 mg/g
* Uncontrolled T2DM defined as HbA1c = 9.5% at screening.
* Inadequately treated hypothyroidism defined as TSH > 1.5 × ULN at screening or participants whose thyroid replacement therapy was initiated or modified within the last 3 months prior to screening.
* Use of mipomersen or lomitapide (cholesterol-lowering medications) within 12 months of screening or planned use during the study.
* Use of gemfibrozil within one week prior to the Screening Visit or planned use during the study.
* Use of PCSK9 inhibitors: evolocumab/alirocumab within 12 weeks of the Screening Visit or planned use during the study, or inclisiran within 18 months of the Screening Visit or planned use during the study, or any other approved PCSK9 inhibitor use within 5 half lives prior to the Screening Visit or planned use during the study.

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Recruiting
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
4/06/2025
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
24/10/2029
Actual
Sample size
Target
15100
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
Recruitment outside Australia
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Heidelberg
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Jena
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Markkleeberg
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Muenster
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Münster
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Nuernberg
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Obertshausen
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Offenbach am Main
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Osnabrück
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Potsdam
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Regensburg
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Rotenburg A.d. Fulda
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Rüsselsheim am Main
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Germany
State/province [199] 0 0
Schwerin
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Germany
State/province [200] 0 0
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Country [201] 0 0
Germany
State/province [201] 0 0
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Country [202] 0 0
Germany
State/province [202] 0 0
Stuttgart
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Germany
State/province [203] 0 0
Trier
Country [204] 0 0
Germany
State/province [204] 0 0
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Country [205] 0 0
Germany
State/province [205] 0 0
Wermsdorf
Country [206] 0 0
Germany
State/province [206] 0 0
Wiesbaden
Country [207] 0 0
Germany
State/province [207] 0 0
Witten
Country [208] 0 0
Greece
State/province [208] 0 0
Alexandroupolis
Country [209] 0 0
Greece
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Athens
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Greece
State/province [210] 0 0
Chios
Country [211] 0 0
Greece
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Heraklion
Country [212] 0 0
Greece
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Country [213] 0 0
Greece
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Larissa
Country [214] 0 0
Greece
State/province [214] 0 0
Piraeus
Country [215] 0 0
Greece
State/province [215] 0 0
Thessaloniki
Country [216] 0 0
Hungary
State/province [216] 0 0
Balatonfüred
Country [217] 0 0
Hungary
State/province [217] 0 0
Budapest
Country [218] 0 0
Hungary
State/province [218] 0 0
Békéscsaba
Country [219] 0 0
Hungary
State/province [219] 0 0
Debrecen
Country [220] 0 0
Hungary
State/province [220] 0 0
Encs
Country [221] 0 0
Hungary
State/province [221] 0 0
Kalocsa
Country [222] 0 0
Hungary
State/province [222] 0 0
Kaposvár
Country [223] 0 0
Hungary
State/province [223] 0 0
Nyíregyháza-Sóstóhegy
Country [224] 0 0
Hungary
State/province [224] 0 0
Nyíregyháza
Country [225] 0 0
Hungary
State/province [225] 0 0
Pécs
Country [226] 0 0
Hungary
State/province [226] 0 0
Szeged
Country [227] 0 0
Hungary
State/province [227] 0 0
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Country [228] 0 0
Hungary
State/province [228] 0 0
Szolnok
Country [229] 0 0
Hungary
State/province [229] 0 0
Székesfehérvár
Country [230] 0 0
Hungary
State/province [230] 0 0
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Country [231] 0 0
Hungary
State/province [231] 0 0
Zalaegerszeg
Country [232] 0 0
India
State/province [232] 0 0
Ahamadabad
Country [233] 0 0
India
State/province [233] 0 0
Bangalore
Country [234] 0 0
India
State/province [234] 0 0
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Country [235] 0 0
India
State/province [235] 0 0
Dehradun
Country [236] 0 0
India
State/province [236] 0 0
Delhi
Country [237] 0 0
India
State/province [237] 0 0
Dwarka
Country [238] 0 0
India
State/province [238] 0 0
Gurgaon
Country [239] 0 0
India
State/province [239] 0 0
Hydarabad
Country [240] 0 0
India
State/province [240] 0 0
Hyderabad
Country [241] 0 0
India
State/province [241] 0 0
Kanpur
Country [242] 0 0
India
State/province [242] 0 0
Kochi
Country [243] 0 0
India
State/province [243] 0 0
Kolkata
Country [244] 0 0
India
State/province [244] 0 0
Ludhiana
Country [245] 0 0
India
State/province [245] 0 0
Manipal
Country [246] 0 0
India
State/province [246] 0 0
Mumbai
Country [247] 0 0
India
State/province [247] 0 0
Nagpur
Country [248] 0 0
India
State/province [248] 0 0
New Dehli
Country [249] 0 0
India
State/province [249] 0 0
New Delhi
Country [250] 0 0
India
State/province [250] 0 0
Vadodara
Country [251] 0 0
India
State/province [251] 0 0
Vijayawada
Country [252] 0 0
Italy
State/province [252] 0 0
Arzignano
Country [253] 0 0
Italy
State/province [253] 0 0
Bergamo
Country [254] 0 0
Italy
State/province [254] 0 0
Bologna
Country [255] 0 0
Italy
State/province [255] 0 0
Brescia
Country [256] 0 0
Italy
State/province [256] 0 0
Caserta
Country [257] 0 0
Italy
State/province [257] 0 0
Catania
Country [258] 0 0
Italy
State/province [258] 0 0
Cona
Country [259] 0 0
Italy
State/province [259] 0 0
Foggia
Country [260] 0 0
Italy
State/province [260] 0 0
Genoa
Country [261] 0 0
Italy
State/province [261] 0 0
Lecco
Country [262] 0 0
Italy
State/province [262] 0 0
Milano
Country [263] 0 0
Italy
State/province [263] 0 0
Napoli
Country [264] 0 0
Italy
State/province [264] 0 0
Novara
Country [265] 0 0
Italy
State/province [265] 0 0
Parma
Country [266] 0 0
Italy
State/province [266] 0 0
Pavia
Country [267] 0 0
Italy
State/province [267] 0 0
Perugia
Country [268] 0 0
Italy
State/province [268] 0 0
Pordenone
Country [269] 0 0
Italy
State/province [269] 0 0
Rivoli
Country [270] 0 0
Italy
State/province [270] 0 0
Roma
Country [271] 0 0
Italy
State/province [271] 0 0
Rozzano
Country [272] 0 0
Italy
State/province [272] 0 0
Torino
Country [273] 0 0
Japan
State/province [273] 0 0
Ami-machi
Country [274] 0 0
Japan
State/province [274] 0 0
Asahi-shi
Country [275] 0 0
Japan
State/province [275] 0 0
Chuo-ku
Country [276] 0 0
Japan
State/province [276] 0 0
Fujisawa-shi
Country [277] 0 0
Japan
State/province [277] 0 0
Hamamatsu-shi
Country [278] 0 0
Japan
State/province [278] 0 0
Higashiyamato-shi
Country [279] 0 0
Japan
State/province [279] 0 0
Hiroshima-shi
Country [280] 0 0
Japan
State/province [280] 0 0
Ichikawa-shi
Country [281] 0 0
Japan
State/province [281] 0 0
Kamakura
Country [282] 0 0
Japan
State/province [282] 0 0
Kanazawa-shi
Country [283] 0 0
Japan
State/province [283] 0 0
Kanoya-shi
Country [284] 0 0
Japan
State/province [284] 0 0
Kashiwara-shi
Country [285] 0 0
Japan
State/province [285] 0 0
Kasuya-gun
Country [286] 0 0
Japan
State/province [286] 0 0
Kishiwada-shi
Country [287] 0 0
Japan
State/province [287] 0 0
Kitakyushu
Country [288] 0 0
Japan
State/province [288] 0 0
Kobe-shi
Country [289] 0 0
Japan
State/province [289] 0 0
Kobe
Country [290] 0 0
Japan
State/province [290] 0 0
Koga-shi
Country [291] 0 0
Japan
State/province [291] 0 0
Komatsu-shi
Country [292] 0 0
Japan
State/province [292] 0 0
Kumamoto-shi
Country [293] 0 0
Japan
State/province [293] 0 0
Kure-shi
Country [294] 0 0
Japan
State/province [294] 0 0
Kyoto-shi
Country [295] 0 0
Japan
State/province [295] 0 0
Matsuyama-city
Country [296] 0 0
Japan
State/province [296] 0 0
Minato-ku
Country [297] 0 0
Japan
State/province [297] 0 0
Miyakonojo-shi
Country [298] 0 0
Japan
State/province [298] 0 0
Miyazaki
Country [299] 0 0
Japan
State/province [299] 0 0
Nagasaki-shi
Country [300] 0 0
Japan
State/province [300] 0 0
Nakagami-gun
Country [301] 0 0
Japan
State/province [301] 0 0
Niigata-shi
Country [302] 0 0
Japan
State/province [302] 0 0
Obu
Country [303] 0 0
Japan
State/province [303] 0 0
Oita-shi
Country [304] 0 0
Japan
State/province [304] 0 0
Okayama-shi
Country [305] 0 0
Japan
State/province [305] 0 0
Omura-shi
Country [306] 0 0
Japan
State/province [306] 0 0
Osaka-shi
Country [307] 0 0
Japan
State/province [307] 0 0
Sapporo-shi
Country [308] 0 0
Japan
State/province [308] 0 0
Shinjuku-ku
Country [309] 0 0
Japan
State/province [309] 0 0
Suita-shi
Country [310] 0 0
Japan
State/province [310] 0 0
Suwa-shi
Country [311] 0 0
Japan
State/province [311] 0 0
Tamana-shi
Country [312] 0 0
Japan
State/province [312] 0 0
Tanabe-shi
Country [313] 0 0
Japan
State/province [313] 0 0
Tokushima-shi
Country [314] 0 0
Japan
State/province [314] 0 0
Toride-shi
Country [315] 0 0
Japan
State/province [315] 0 0
Tsukuba-shi
Country [316] 0 0
Japan
State/province [316] 0 0
Urasoe-Shi
Country [317] 0 0
Japan
State/province [317] 0 0
Urayasu-shi
Country [318] 0 0
Japan
State/province [318] 0 0
Ushiku-shi
Country [319] 0 0
Japan
State/province [319] 0 0
Utsunomiya-shi
Country [320] 0 0
Japan
State/province [320] 0 0
Yokohama City
Country [321] 0 0
Japan
State/province [321] 0 0
Yokohama-shi
Country [322] 0 0
Korea, Republic of
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Bucheon-si
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Korea, Republic of
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Busan
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Korea, Republic of
State/province [324] 0 0
Changwon-si
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Korea, Republic of
State/province [325] 0 0
Daegu
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Korea, Republic of
State/province [326] 0 0
Daejeon
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Korea, Republic of
State/province [327] 0 0
Goyang-si
Country [328] 0 0
Korea, Republic of
State/province [328] 0 0
Gwangju
Country [329] 0 0
Korea, Republic of
State/province [329] 0 0
Gwangmyeong-si
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Korea, Republic of
State/province [330] 0 0
Jung-gu
Country [331] 0 0
Korea, Republic of
State/province [331] 0 0
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Korea, Republic of
State/province [332] 0 0
Suncheon
Country [333] 0 0
Korea, Republic of
State/province [333] 0 0
Yongin-si
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Malaysia
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Alor Setar
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Malaysia
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George Town
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Malaysia
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Kajang
Country [337] 0 0
Malaysia
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Kota Kinabalu
Country [338] 0 0
Malaysia
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Kota Samarahan
Country [339] 0 0
Malaysia
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Kuala Lumpur
Country [340] 0 0
Malaysia
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Kuala Terengganu
Country [341] 0 0
Malaysia
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Kuantan
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Malaysia
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Kuching
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Malaysia
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Sarawak Miri
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Malaysia
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Seri Manjung
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Mexico
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Acapulco
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Mexico
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Mexico
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Chihuahua
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Mexico
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Ciudad de México
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Mexico
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Mexico
State/province [350] 0 0
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Mexico
State/province [351] 0 0
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Mexico
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Mexico
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Mexico City
Country [354] 0 0
Mexico
State/province [354] 0 0
Mexico
Country [355] 0 0
Mexico
State/province [355] 0 0
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Mexico
State/province [356] 0 0
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Mexico
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México
Country [358] 0 0
Mexico
State/province [358] 0 0
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Country [359] 0 0
Mexico
State/province [359] 0 0
San Juan del Rio
Country [360] 0 0
Mexico
State/province [360] 0 0
Veracruz
Country [361] 0 0
Mexico
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Zapopan
Country [362] 0 0
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New Zealand
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Christchurch
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New Zealand
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Ebdentown
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New Zealand
State/province [365] 0 0
Grafton
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New Zealand
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Hamilton
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New Zealand
State/province [367] 0 0
Hastings
Country [368] 0 0
New Zealand
State/province [368] 0 0
Hutt Central
Country [369] 0 0
New Zealand
State/province [369] 0 0
New Lynn
Country [370] 0 0
New Zealand
State/province [370] 0 0
Palmerston North Central
Country [371] 0 0
New Zealand
State/province [371] 0 0
Papatoetoe
Country [372] 0 0
New Zealand
State/province [372] 0 0
Pukekohe
Country [373] 0 0
New Zealand
State/province [373] 0 0
Rotorua
Country [374] 0 0
New Zealand
State/province [374] 0 0
Woodhill
Country [375] 0 0
Peru
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Bellavista
Country [376] 0 0
Peru
State/province [376] 0 0
Chorrillos
Country [377] 0 0
Peru
State/province [377] 0 0
Lima
Country [378] 0 0
Peru
State/province [378] 0 0
Miraflores
Country [379] 0 0
Peru
State/province [379] 0 0
Piura
Country [380] 0 0
Peru
State/province [380] 0 0
San Isidro
Country [381] 0 0
Peru
State/province [381] 0 0
Wanchac
Country [382] 0 0
Philippines
State/province [382] 0 0
Angeles City
Country [383] 0 0
Philippines
State/province [383] 0 0
Baguio City
Country [384] 0 0
Philippines
State/province [384] 0 0
Cebu
Country [385] 0 0
Philippines
State/province [385] 0 0
Davao City
Country [386] 0 0
Philippines
State/province [386] 0 0
Davao
Country [387] 0 0
Philippines
State/province [387] 0 0
Iloilo City
Country [388] 0 0
Philippines
State/province [388] 0 0
Laguna
Country [389] 0 0
Philippines
State/province [389] 0 0
Manadaluyong City
Country [390] 0 0
Philippines
State/province [390] 0 0
Manila
Country [391] 0 0
Philippines
State/province [391] 0 0
Marikina
Country [392] 0 0
Philippines
State/province [392] 0 0
Pasig City
Country [393] 0 0
Philippines
State/province [393] 0 0
Quezon City
Country [394] 0 0
Philippines
State/province [394] 0 0
San Juan
Country [395] 0 0
Philippines
State/province [395] 0 0
Tacloban City
Country [396] 0 0
Poland
State/province [396] 0 0
Bialystok
Country [397] 0 0
Poland
State/province [397] 0 0
Bydgoszcz
Country [398] 0 0
Poland
State/province [398] 0 0
Gdansk
Country [399] 0 0
Poland
State/province [399] 0 0
Gdynia
Country [400] 0 0
Poland
State/province [400] 0 0
Jelenia Góra
Country [401] 0 0
Poland
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Katowice
Country [402] 0 0
Poland
State/province [402] 0 0
Kraków
Country [403] 0 0
Poland
State/province [403] 0 0
Kedzierzyn-Kozle
Country [404] 0 0
Poland
State/province [404] 0 0
Lublin
Country [405] 0 0
Poland
State/province [405] 0 0
Ostrów Mazowiecka
Country [406] 0 0
Poland
State/province [406] 0 0
Poznan
Country [407] 0 0
Poland
State/province [407] 0 0
Plock
Country [408] 0 0
Poland
State/province [408] 0 0
Ruda Slaska
Country [409] 0 0
Poland
State/province [409] 0 0
Rzeszów
Country [410] 0 0
Poland
State/province [410] 0 0
Szczecin
Country [411] 0 0
Poland
State/province [411] 0 0
Tarnów
Country [412] 0 0
Poland
State/province [412] 0 0
Torun
Country [413] 0 0
Poland
State/province [413] 0 0
Warszawa
Country [414] 0 0
Poland
State/province [414] 0 0
Wroclaw
Country [415] 0 0
Poland
State/province [415] 0 0
Lódz
Country [416] 0 0
Romania
State/province [416] 0 0
Arad
Country [417] 0 0
Romania
State/province [417] 0 0
Bacau
Country [418] 0 0
Romania
State/province [418] 0 0
Bucharest
Country [419] 0 0
Romania
State/province [419] 0 0
Bucuresti
Country [420] 0 0
Romania
State/province [420] 0 0
Craiova
Country [421] 0 0
Romania
State/province [421] 0 0
Iasi
Country [422] 0 0
Romania
State/province [422] 0 0
Oradea
Country [423] 0 0
Romania
State/province [423] 0 0
Satu Mare
Country [424] 0 0
Romania
State/province [424] 0 0
Targu Mures
Country [425] 0 0
Romania
State/province [425] 0 0
Timisoara
Country [426] 0 0
Romania
State/province [426] 0 0
Tirgu-Mures
Country [427] 0 0
Slovakia
State/province [427] 0 0
Bratislava
Country [428] 0 0
Slovakia
State/province [428] 0 0
Brezno
Country [429] 0 0
Slovakia
State/province [429] 0 0
Dolný Kubín
Country [430] 0 0
Slovakia
State/province [430] 0 0
Kosice
Country [431] 0 0
Slovakia
State/province [431] 0 0
Košice
Country [432] 0 0
Slovakia
State/province [432] 0 0
Levice
Country [433] 0 0
Slovakia
State/province [433] 0 0
Malacky
Country [434] 0 0
Slovakia
State/province [434] 0 0
Nitra
Country [435] 0 0
Slovakia
State/province [435] 0 0
Presov
Country [436] 0 0
Slovakia
State/province [436] 0 0
Prešov
Country [437] 0 0
Slovakia
State/province [437] 0 0
Trnava
Country [438] 0 0
Slovakia
State/province [438] 0 0
Vinica
Country [439] 0 0
Slovakia
State/province [439] 0 0
Zilina
Country [440] 0 0
Slovakia
State/province [440] 0 0
Šamorín
Country [441] 0 0
South Africa
State/province [441] 0 0
Bellville
Country [442] 0 0
South Africa
State/province [442] 0 0
Benoni
Country [443] 0 0
South Africa
State/province [443] 0 0
Bloemfontein
Country [444] 0 0
South Africa
State/province [444] 0 0
Brackenfell
Country [445] 0 0
South Africa
State/province [445] 0 0
Cape Town
Country [446] 0 0
South Africa
State/province [446] 0 0
Centurion
Country [447] 0 0
South Africa
State/province [447] 0 0
Durban
Country [448] 0 0
South Africa
State/province [448] 0 0
George
Country [449] 0 0
South Africa
State/province [449] 0 0
Johannesburg
Country [450] 0 0
South Africa
State/province [450] 0 0
Kimberley
Country [451] 0 0
South Africa
State/province [451] 0 0
Middelbrug
Country [452] 0 0
South Africa
State/province [452] 0 0
Midrand
Country [453] 0 0
South Africa
State/province [453] 0 0
Paarl
Country [454] 0 0
South Africa
State/province [454] 0 0
Panorama
Country [455] 0 0
South Africa
State/province [455] 0 0
Pretoria
Country [456] 0 0
South Africa
State/province [456] 0 0
Somerset West
Country [457] 0 0
South Africa
State/province [457] 0 0
Umhlanga Rocks
Country [458] 0 0
South Africa
State/province [458] 0 0
Umkomaas
Country [459] 0 0
Spain
State/province [459] 0 0
A Coruna
Country [460] 0 0
Spain
State/province [460] 0 0
Alicante
Country [461] 0 0
Spain
State/province [461] 0 0
Barcelona
Country [462] 0 0
Spain
State/province [462] 0 0
Madrid
Country [463] 0 0
Spain
State/province [463] 0 0
Murcia
Country [464] 0 0
Spain
State/province [464] 0 0
Málaga
Country [465] 0 0
Spain
State/province [465] 0 0
Palma de Mallorca
Country [466] 0 0
Spain
State/province [466] 0 0
Sanlúcar De Barrameda (Cádiz)
Country [467] 0 0
Spain
State/province [467] 0 0
Santiago(A Coruña)
Country [468] 0 0
Spain
State/province [468] 0 0
Sevilla
Country [469] 0 0
Spain
State/province [469] 0 0
Tarragona
Country [470] 0 0
Spain
State/province [470] 0 0
Valencia
Country [471] 0 0
Spain
State/province [471] 0 0
Vigo
Country [472] 0 0
Spain
State/province [472] 0 0
Villamartín (Cádiz)
Country [473] 0 0
Sweden
State/province [473] 0 0
Alingsås
Country [474] 0 0
Sweden
State/province [474] 0 0
Falun
Country [475] 0 0
Sweden
State/province [475] 0 0
Huddinge
Country [476] 0 0
Sweden
State/province [476] 0 0
Lund
Country [477] 0 0
Sweden
State/province [477] 0 0
Stockholm
Country [478] 0 0
Sweden
State/province [478] 0 0
Umeå
Country [479] 0 0
Sweden
State/province [479] 0 0
Uppsala
Country [480] 0 0
Sweden
State/province [480] 0 0
Vasteras
Country [481] 0 0
Taiwan
State/province [481] 0 0
Changhua
Country [482] 0 0
Taiwan
State/province [482] 0 0
Hsinchu
Country [483] 0 0
Taiwan
State/province [483] 0 0
Hualien City
Country [484] 0 0
Taiwan
State/province [484] 0 0
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Hat Yai
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Khon-Kaen
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State/province [499] 0 0
Klong Luang
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Mueang
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Chernivtsi
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Gateshead
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London
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Poole
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West Bromwich
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Can Tho
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Vietnam
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Danang
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Vietnam
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Hai Phong
Country [545] 0 0
Vietnam
State/province [545] 0 0
Ho Chi Minh City
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Ho Chi Minh
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Vietnam
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Hue

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
AstraZeneca
Country

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Public notes

Contacts
Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Email 0 0
Contact person for public queries
Name 0 0
AstraZeneca Clinical Study Information Center
Address 0 0
Country 0 0
Phone 0 0
1-877-240-9479
Email 0 0
information.center@astrazeneca.com
Contact person for scientific queries

Data sharing statement


What supporting documents are/will be available?

No Supporting Document Provided


Results publications and other study-related documents

No documents have been uploaded by study researchers.

Results not provided in https://clinicaltrials.gov/study/NCT07000357