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Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
Effect of Ghrelin on Sympathetic Nervous System
Scientific title
Effect of Ghrelin on Sympathetic Nervous System and Stress Reactivity
Secondary ID [1] 0 0
Secondary ID [2] 0 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Healthy 0 0
Obesity 0 0
Condition category
Condition code

Study type
Description of intervention(s) / exposure
Treatment: Drugs - ghrelin

Treatment: Drugs: ghrelin
0.1 microgram/kg/min, intravenous for 60 minutes

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Primary outcome [1] 0 0
Sympathetic nervous activity
Timepoint [1] 0 0
60 min
Secondary outcome [1] 0 0
blood pressure
Timepoint [1] 0 0
60 min

Key inclusion criteria
- healthy lean subjects with a BMI < 25 kg/m2 and subjects with central obesity
(according to IDF definition)
Minimum age
18 Years
Maximum age
65 Years
Can healthy volunteers participate?
Key exclusion criteria
- any current medication

- a history of diabetes

- hypertension

- cardiovascular, cerebrovascular, liver, thyroid disease

- mental illness

Study design
Purpose of the study
Basic Science
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s

Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
Alfred & Baker Medical Unit - Melbourne
Recruitment postcode(s) [1] 0 0
3004 - Melbourne

Funding & Sponsors
Primary sponsor type
Baker Heart and Diabetes Institute

Ethics approval
Ethics application status

Brief summary
Ghrelin is a newly discovered peptide that is secreted by the stomach. Its main role is to
stimulate food intake but recent studies indicate that it also acts on the cardiovascular
system to confer beneficial effects. The mechanism of action is unclear but experimental
studies suggest that ghrelin decreases the sympathetic nervous system. Beside there is new
evidence in animal models that ghrelin may also be involved in stress reaction as ghrelin
injection seems to protect against symptoms of stress. Given that circulating levels of
ghrelin are reduced in obesity, this suggests that the effect of ghrelin may differ between
lean and obese subjects. Ghrelin could represent an attractive therapeutic strategy for the
treatment of cardiovascular diseases. The aim of the study if to gain more knowledge of the
effect of ghrelin on the sympathetic nervous system and stress reactivity in both lean and
obese subjects.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Summary results
Other publications