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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT06667765




Registration number
NCT06667765
Ethics application status
Date submitted
30/10/2024
Date registered
31/10/2024

Titles & IDs
Public title
A Study of RPT1G After Single and Multiple Doses in Healthy Adult Participants
Scientific title
A Randomized, Placebo-Controlled, Double-Blinded Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RPT1G After Single and Multiple Doses in Healthy Adult Participants
Secondary ID [1] 0 0
RPT1G
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Healthy 0 0
Condition category
Condition code

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - RPT1G
Treatment: Drugs - Placebo

Experimental: RPT1G Single ascending dose (SAD) cohort - All participants will receive single oral dose of RPT1G or placebo in fasted state

Experimental: RPT1G Multiple ascending dose (MAD) cohort - All participants will receive twice daily oral doses of RPT1G or placebo in a fasted state for 5 days


Treatment: Drugs: RPT1G
Dose formulation- Oral capsule

Treatment: Drugs: Placebo
Dose formulation- Oral capsule
Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
To assess the safety of RPT1G by number of adverse events in accordance with CTCAE V5
Timepoint [1] 0 0
SAD-Day 1 to Day 8 post first dose administration; MAD- Day1 to Day 12 post first dose administration
Secondary outcome [1] 0 0
To evaluate the pharmacokinetics (PK) of RPT1G
Timepoint [1] 0 0
Up to 8 days post first dose administration
Secondary outcome [2] 0 0
To evaluate the pharmacokinetics (PK) of RPT1G
Timepoint [2] 0 0
Up to 8 days post first dose administration
Secondary outcome [3] 0 0
To evaluate the pharmacokinetics (PK) of RPT1G
Timepoint [3] 0 0
Up to 8 days post first dose administration
Secondary outcome [4] 0 0
To evaluate the pharmacokinetics (PK) of RPT1G
Timepoint [4] 0 0
Up to 8 days post first dose administration
Secondary outcome [5] 0 0
To evaluate the pharmacokinetics (PK) of RPT1G
Timepoint [5] 0 0
Up to 8 days post first dose administration
Secondary outcome [6] 0 0
To evaluate the pharmacokinetics (PK) of RPT1G
Timepoint [6] 0 0
Up to 8 days post first dose administration

Eligibility
Key inclusion criteria
1. Must be able to understand and provide written informed consent prior to initiation of study procedures, able to abide by the study restrictions, and remain confined in the research unit as required.
2. Must be = 18 and = 55 years of age, at Screening.
3. Have a body weight = 48 kg (105.6 lbs) and body mass index (BMI) = 18.0 and < 32.0 kg/meter square at Screening, with no clinically significant change in body weight at Check-in as determined by the Investigator.
4. Must be in good health and without clinically significant abnormalities as assessed by review of medical and surgical history, physical examination, vital signs measurement, ophthalmoscopic assessment, and 12-lead ECG at Screening and Check-in as assessed by the Investigator.
5. Laboratory evaluations or laboratory parameters are within the reference range (laboratory parameters outside the reference range may be included only if the Investigator considers that the findings are not clinically significant and agreement by the Sponsor's Medical Monitor is obtained, and inclusion of the participant will not introduce additional risk factors and will not interfere with the study procedures) at Screening and Check-in. One additional repeat laboratory evaluation may be permitted at the Investigator's discretion.
6. Female participants are eligible to enroll and participate in the study if they meet the definition of non-childbearing potential. Women of childbearing potential (WOCBP) can enroll if they have a negative serum pregnancy test result at Screening and agree to comply with the contraception requirements of the protocol. A pregnancy test must also be performed within 72 hours before Day 1 of study dosing.
7. Male participants are eligible to enroll if they agree to comply with the contraception requirements of the protocol.
8. Male participants must agree to not donate sperm during participation in the study starting at Screening and for 3 months following the administration of the last study dose. Female participants must refrain from donating ova and/or breastfeeding during participation in the study and for 30 days following the administration of the last study dose.
Minimum age
18 Years
Maximum age
55 Years
Sex
Both males and females
Can healthy volunteers participate?
Yes
Key exclusion criteria
1. Participant is an employee of the Sponsor, including employees contracted by the Sponsor (i.e., consultants) or an employee of the contract research organization (CRO), or an employee of the site/institution.
2. Any sign or symptom that may indicate an active infection.
3. History of chronic or recurrent infections, or a serious or life-threatening infection within the 6 months prior to Check-in.
4. Hospitalization within 2 months prior to Check-in or major surgical procedure (per Investigator's discretion) of any type within 3 months prior to Check- in.
5. Significant history or clinical manifestation of any metabolic, allergic, autoimmune, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, ocular, oncologic ( concurrent malignancy or a history of malignancy during the past 5 years, except for basal cell or squamous cell carcinoma-in-situ of the skin that have been successfully excised, or ablated, with no evidence of metastatic disease for 3 years), respiratory, endocrine, or psychiatric disorder, as determined by the Investigator (or designee) that would jeopardize the safety of the individual or the validity of the study results, including any condition that would affect drug absorption, distribution, metabolism, or excretion of drugs (e.g., stomach or intestinal surgery, or gallbladder removal/cholecystectomy; uncomplicated appendectomy and hernia repair will be allowed).
6. Prior treatment with a nicotinamide phosphoribosyltransferase (NAMPT) inhibitor.
7. Use of immunosuppressant therapies or chemotherapy agents or steroids (topical or intranasal steroids for the treatment of hay fever are permissible) within 3 months prior to Screening.
8. History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, unless approved by the Investigator (or designee).
9. Individuals with congenital nonhemolytic hyperbilirubinemia (e.g., suspicion of Gilbert's syndrome based on total and direct bilirubin).
10. Screening or Check-in 12-lead ECG shows:

1. Prolonged corrected QT interval by Fridericia's method (QTcF) (i.e., QTcF > 450 ms for males and > 470 ms for females)
2. Other clinically significant abnormalities.
11. Estimated creatinine clearance < 90 mL/min using the Cockcroft-Gault equation at Screening or Check-in.
12. Positive pregnancy test or is lactating (WOCBP) at Screening or Check-in.
13. Has a positive test for human immunodeficiency virus (HIV)-1 or HIV-2 antibodies, hepatitis panel (Hepatitis B surface antibody [HBsAb], Hepatitis B core antibody [HBcAb], and Hepatitis C virus antibody [HCVAb]) or tuberculosis (TB) blood test (e.g., QuantiFERON TB Gold Plus test) at Screening.
14. Use or history of the following: History of alcoholism or drug/chemical abuse within 2 years prior to Check-in. Any use of alcohol within 48 hours of admission to the CRU or positive urine alcohol test result at Check-in. Use of more than 10 tobacco or nicotine containing products (including e-vapor products) per week, or use of any marijuana containing products within 4 weeks prior to Check-in, or positive cotinine at Screening or Check-in. Positive urine drug screen at Screening or Check-in. For each test, one repeat test may be permitted at the Investigator's discretion.
15. Has participated in any investigational study intervention trial in which receipt of an investigational study intervention occurred within 30 days prior to Check-in or 5 half-lives of the investigational intervention's PK, PD, or biological activity (if known), whichever is longer, or is currently participating in another clinical study.
16. Use or intent to use any medications within 30 days or 5 half-lives (whichever is longer) prior to Check-in, unless deemed acceptable by the Investigator (or designee) with agreement by the Medical Monitor.
17. Use or intent to use natural products or nutritional/dietary supplements (including St. John's wort), vitamins, minerals, and phytotherapeutic/herbal/plant-derived preparations within or received within 14 days or 5 half-lives (whichever is longer) prior to Check-in, unless deemed acceptable by the Investigator (or designee) with agreement by the Sponsor's Medical Monitor.
18. Ingestion of Seville/blood oranges, grapefruit, grapefruit hybrids, or marmalade or fruit juice products made from Seville/blood oranges, grapefruit or grapefruit hybrids within 7 days prior to Check-in per the Investigator's discretion.
19. Poor peripheral venous access, receipt of blood products within 2 months prior to Checkin, loss or donation of more than 400mL of blood or blood products during the 8 weeks prior to Check-in, or donation of any blood or blood products during the 2 weeks prior to Check-in.
20. Known history of allergy to any component of study intervention, including excipient(s).
21. Individuals with LFTs > 1.5x ULN.
22. Individuals who, in the opinion of the Investigator (or designee), should not participate in this study.
23. Individuals who have already been enrolled and dosed on this study.

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s

The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 1
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Not yet recruiting
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
18/11/2024
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
15/05/2025
Actual
Sample size
Target
56
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
SA
Recruitment hospital [1] 0 0
CMAX Clinical Research Pty Ltd - Adelaide
Recruitment postcode(s) [1] 0 0
5000 - Adelaide

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
Remedy Plan, Inc.
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Gregory Crimmins
Address 0 0
Country 0 0
Phone 0 0
+1 240 408 4854
Fax 0 0
Email 0 0
clinical@remedyplan.com
Contact person for scientific queries

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No
No/undecided IPD sharing reason/comment


What supporting documents are/will be available?

No Supporting Document Provided



Results publications and other study-related documents

No documents have been uploaded by study researchers.


Results not provided in https://clinicaltrials.gov/study/NCT06667765