Register a trial

Please note the ANZCTR will be unattended from Friday 20 December 2024 for the holidays. The Registry will re-open on Tuesday 7 January 2025. Submissions and updates will not be processed during that time.

Registering a new trial?

To achieve prospective registration, we recommend submitting your trial for registration at the same time as ethics submission.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT05952557




Registration number
NCT05952557
Ethics application status
Date submitted
17/05/2023
Date registered
19/07/2023

Titles & IDs
Public title
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
Scientific title
CAMBRIA-2: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) vs Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients With ER+/HER2- Early Breast Cancer and an Intermediate-High or High Risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease
Secondary ID [1] 0 0
2023-504031-41-00
Secondary ID [2] 0 0
D8535C00001
Universal Trial Number (UTN)
Trial acronym
CAMBRIA-2
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Breast Cancer, Early Breast Cancer 0 0
Condition category
Condition code
Cancer 0 0 0 0
Breast

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Camizestrant
Treatment: Drugs - Tamoxifen
Treatment: Drugs - Anastrozole
Treatment: Drugs - Letrozole
Treatment: Drugs - Exemestane
Treatment: Drugs - Abemaciclib

Active comparator: Arm A: standard endocrine therapy of investigator´s choice ± abemaciclib - standard endocrine therapy of investigator's choice (aromatase inhibitors \[AI; exemestane, letrozole, anastrozole\] or tamoxifen) ± abemaciclib

Experimental: Arm B: camizestrant ± abemaciclib - camizestrant ± abemaciclib


Treatment: Drugs: Camizestrant
Camizestrant. Experimental. Administered orally

Treatment: Drugs: Tamoxifen
Tamoxifen. Comparator. Administered orally

Treatment: Drugs: Anastrozole
Anastrozole. Comparator. Administered orally

Treatment: Drugs: Letrozole
Letrozole. Comparator. Administered orally

Treatment: Drugs: Exemestane
Exemestane. Comparator. Administered orally

Treatment: Drugs: Abemaciclib
Abemaciclib adjuvant treatment Administered orally
Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Invasive breast cancer-free survival (IBCFS)
Timepoint [1] 0 0
Up to 14 years
Secondary outcome [1] 0 0
Invasive disease-free survival (IDFS)
Timepoint [1] 0 0
Up to 14 years
Secondary outcome [2] 0 0
Distant relapse-free survival (DRFS)
Timepoint [2] 0 0
Up to 14 years
Secondary outcome [3] 0 0
Overall survival (OS)
Timepoint [3] 0 0
Up to 14 years
Secondary outcome [4] 0 0
Incidence and Severity of Adverse Events, with Severity Determined According to National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0 (NCI-CTCAE v5.0)
Timepoint [4] 0 0
Until 28 days after the final dose of study treatment (up to 7 years)
Secondary outcome [5] 0 0
Proportion of time on study treatment with high side-effect burden as measured by the PGI-TT.
Timepoint [5] 0 0
Until 28 days after the final dose of study treatment (up to 7 years)
Secondary outcome [6] 0 0
Change from baseline and time to deterioration of health-related quality of life as measured by the 2 global QoL items from the EORTC IL-311
Timepoint [6] 0 0
Until 28 days after the final dose of study treatment (up to 7 years)
Secondary outcome [7] 0 0
Pharmacokinetics (PK)
Timepoint [7] 0 0
Until 6 months from treatment start

Eligibility
Key inclusion criteria
* Women and Men; =18 years at the time of screening (or per national guidelines)
* Histologically confirmed ER+/HER2- early-stage resected invasive breast cancer with absence of any evidence of metastatic disease as defined in the protocol.
* Completed adequate (definitive) locoregional therapy (surgery with or without radiotherapy) for the primary breast tumour(s), with or without (neo)adjuvant chemotherapy.
* Patients must be randomised within 12 months of definitive breast surgery.
* Patients may have received up to 12 weeks of endocrine therapy prior to randomisation.
* Eastern Cooperative Oncology Group (ECOG) performance status of = 1
* Adequate organ and bone marrow function
Minimum age
18 Years
Maximum age
130 Years
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Inoperable locally advanced or metastatic breast cancer
* Pathological complete response following treatment with neoadjuvant therapy
* History of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix or considered a very low risk of recurrence per investigator judgement) unless in complete remission with no therapy for a minimum of 5 years from the date of randomisation
* Any evidence of severe or uncontrolled systemic diseases which, in the investigator's opinion precludes participation in the study or compliance "
* Known LVEF <50% with heart failure NYHA Grade =2.
* Mean resting QTcF interval > 480 ms at screening
* Concurrent exogenous reproductive hormone therapy or non topical hormonal therapy for non-cancer-related conditions
* Any concurrent anti-cancer treatment not specified in the protocol with the exception of bisphosphonates (e.g. zoledronic acid) or RANKL inhibitors ( eg, denosumab)
* Previous treatment with camizestrant, investigational SERDs/investigational ER targeting agents, or fulvestrant
* Currently pregnant (confirmed with positive serum pregnancy test) or breastfeeding.
* Patients with known hypersensitivity to active or inactive excipients of camizestrant or drugs with a similar chemical structure or class to camizestrant. In pre-/peri-menopausal female and male patients, known hypersensitivity or intolerance to LHRH agonists that would preclude the patient from receiving any LHRH agonist.

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?



Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Recruiting
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
5/10/2023
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
6/05/2037
Actual
Sample size
Target
5500
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
Research Site - Adelaide
Recruitment hospital [2] 0 0
Research Site - Bankstown
Recruitment hospital [3] 0 0
Research Site - Bendigo
Recruitment hospital [4] 0 0
Research Site - Bowral
Recruitment hospital [5] 0 0
Research Site - Brighton
Recruitment hospital [6] 0 0
Research Site - Clayton
Recruitment hospital [7] 0 0
Research Site - Coffs Harbour
Recruitment hospital [8] 0 0
Research Site - Fitzroy
Recruitment hospital [9] 0 0
Research Site - Frankston
Recruitment hospital [10] 0 0
Research Site - Gateshead
Recruitment hospital [11] 0 0
Research Site - Heidelberg
Recruitment hospital [12] 0 0
Research Site - Liverpool
Recruitment hospital [13] 0 0
Research Site - Melbourne
Recruitment hospital [14] 0 0
Research Site - Murdoch
Recruitment hospital [15] 0 0
Research Site - Randwick
Recruitment hospital [16] 0 0
Research Site - Richmond
Recruitment hospital [17] 0 0
Research Site - Shepparton
Recruitment hospital [18] 0 0
Research Site - South Brisbane
Recruitment hospital [19] 0 0
Research Site - St Leonards
Recruitment hospital [20] 0 0
Research Site - Subiaco
Recruitment hospital [21] 0 0
Research Site - Traralgon
Recruitment hospital [22] 0 0
Research Site - Wangaratta
Recruitment hospital [23] 0 0
Research Site - Waratah
Recruitment hospital [24] 0 0
Research Site - Warnnambool
Recruitment hospital [25] 0 0
Research Site - Wollongong
Recruitment postcode(s) [1] 0 0
5081 - Adelaide
Recruitment postcode(s) [2] 0 0
2200 - Bankstown
Recruitment postcode(s) [3] 0 0
3550 - Bendigo
Recruitment postcode(s) [4] 0 0
2576 - Bowral
Recruitment postcode(s) [5] 0 0
3186 - Brighton
Recruitment postcode(s) [6] 0 0
3168 - Clayton
Recruitment postcode(s) [7] 0 0
2450 - Coffs Harbour
Recruitment postcode(s) [8] 0 0
3065 - Fitzroy
Recruitment postcode(s) [9] 0 0
3199 - Frankston
Recruitment postcode(s) [10] 0 0
2290 - Gateshead
Recruitment postcode(s) [11] 0 0
3084 - Heidelberg
Recruitment postcode(s) [12] 0 0
2170 - Liverpool
Recruitment postcode(s) [13] 0 0
3004 - Melbourne
Recruitment postcode(s) [14] 0 0
WA6150 - Murdoch
Recruitment postcode(s) [15] 0 0
2031 - Randwick
Recruitment postcode(s) [16] 0 0
3121 - Richmond
Recruitment postcode(s) [17] 0 0
3630 - Shepparton
Recruitment postcode(s) [18] 0 0
4101 - South Brisbane
Recruitment postcode(s) [19] 0 0
2065 - St Leonards
Recruitment postcode(s) [20] 0 0
6008 - Subiaco
Recruitment postcode(s) [21] 0 0
3844 - Traralgon
Recruitment postcode(s) [22] 0 0
3677 - Wangaratta
Recruitment postcode(s) [23] 0 0
2298 - Waratah
Recruitment postcode(s) [24] 0 0
3280 - Warnnambool
Recruitment postcode(s) [25] 0 0
2500 - Wollongong
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
Arkansas
Country [4] 0 0
United States of America
State/province [4] 0 0
California
Country [5] 0 0
United States of America
State/province [5] 0 0
Colorado
Country [6] 0 0
United States of America
State/province [6] 0 0
Connecticut
Country [7] 0 0
United States of America
State/province [7] 0 0
Delaware
Country [8] 0 0
United States of America
State/province [8] 0 0
Florida
Country [9] 0 0
United States of America
State/province [9] 0 0
Georgia
Country [10] 0 0
United States of America
State/province [10] 0 0
Illinois
Country [11] 0 0
United States of America
State/province [11] 0 0
Indiana
Country [12] 0 0
United States of America
State/province [12] 0 0
Iowa
Country [13] 0 0
United States of America
State/province [13] 0 0
Kansas
Country [14] 0 0
United States of America
State/province [14] 0 0
Kentucky
Country [15] 0 0
United States of America
State/province [15] 0 0
Louisiana
Country [16] 0 0
United States of America
State/province [16] 0 0
Maine
Country [17] 0 0
United States of America
State/province [17] 0 0
Maryland
Country [18] 0 0
United States of America
State/province [18] 0 0
Massachusetts
Country [19] 0 0
United States of America
State/province [19] 0 0
Michigan
Country [20] 0 0
United States of America
State/province [20] 0 0
Minnesota
Country [21] 0 0
United States of America
State/province [21] 0 0
Missouri
Country [22] 0 0
United States of America
State/province [22] 0 0
Nebraska
Country [23] 0 0
United States of America
State/province [23] 0 0
New Hampshire
Country [24] 0 0
United States of America
State/province [24] 0 0
New Jersey
Country [25] 0 0
United States of America
State/province [25] 0 0
New Mexico
Country [26] 0 0
United States of America
State/province [26] 0 0
New York
Country [27] 0 0
United States of America
State/province [27] 0 0
North Carolina
Country [28] 0 0
United States of America
State/province [28] 0 0
Ohio
Country [29] 0 0
United States of America
State/province [29] 0 0
Oklahoma
Country [30] 0 0
United States of America
State/province [30] 0 0
Oregon
Country [31] 0 0
United States of America
State/province [31] 0 0
Pennsylvania
Country [32] 0 0
United States of America
State/province [32] 0 0
South Carolina
Country [33] 0 0
United States of America
State/province [33] 0 0
South Dakota
Country [34] 0 0
United States of America
State/province [34] 0 0
Tennessee
Country [35] 0 0
United States of America
State/province [35] 0 0
Texas
Country [36] 0 0
United States of America
State/province [36] 0 0
Utah
Country [37] 0 0
United States of America
State/province [37] 0 0
Virginia
Country [38] 0 0
United States of America
State/province [38] 0 0
Washington
Country [39] 0 0
United States of America
State/province [39] 0 0
West Virginia
Country [40] 0 0
United States of America
State/province [40] 0 0
Wisconsin
Country [41] 0 0
Argentina
State/province [41] 0 0
Buenos Aires
Country [42] 0 0
Argentina
State/province [42] 0 0
Caba
Country [43] 0 0
Argentina
State/province [43] 0 0
Capital Federal
Country [44] 0 0
Argentina
State/province [44] 0 0
Ciudad Autonoma de Buenos Aires
Country [45] 0 0
Argentina
State/province [45] 0 0
Ciudad de Córdoba
Country [46] 0 0
Argentina
State/province [46] 0 0
Cordoba
Country [47] 0 0
Argentina
State/province [47] 0 0
La Plata
Country [48] 0 0
Argentina
State/province [48] 0 0
Rosario
Country [49] 0 0
Argentina
State/province [49] 0 0
San Juan
Country [50] 0 0
Argentina
State/province [50] 0 0
San Miguel de Tucuman
Country [51] 0 0
Argentina
State/province [51] 0 0
Viedma
Country [52] 0 0
Austria
State/province [52] 0 0
Graz
Country [53] 0 0
Austria
State/province [53] 0 0
Innsbruck
Country [54] 0 0
Austria
State/province [54] 0 0
Klagenfurt
Country [55] 0 0
Austria
State/province [55] 0 0
Linz
Country [56] 0 0
Austria
State/province [56] 0 0
Salzburg
Country [57] 0 0
Austria
State/province [57] 0 0
St. Veit an der Glan
Country [58] 0 0
Austria
State/province [58] 0 0
Steyr
Country [59] 0 0
Austria
State/province [59] 0 0
Vienna
Country [60] 0 0
Austria
State/province [60] 0 0
Wels
Country [61] 0 0
Austria
State/province [61] 0 0
Wiener Neustadt
Country [62] 0 0
Austria
State/province [62] 0 0
Wien
Country [63] 0 0
Belgium
State/province [63] 0 0
Aalst
Country [64] 0 0
Belgium
State/province [64] 0 0
Anderlecht
Country [65] 0 0
Belgium
State/province [65] 0 0
Brasschaat
Country [66] 0 0
Belgium
State/province [66] 0 0
Bruxelles
Country [67] 0 0
Belgium
State/province [67] 0 0
Charleroi
Country [68] 0 0
Belgium
State/province [68] 0 0
Edegem
Country [69] 0 0
Belgium
State/province [69] 0 0
Gent
Country [70] 0 0
Belgium
State/province [70] 0 0
Leuven
Country [71] 0 0
Belgium
State/province [71] 0 0
Namur
Country [72] 0 0
Belgium
State/province [72] 0 0
Wilrijk
Country [73] 0 0
Brazil
State/province [73] 0 0
Alfenas
Country [74] 0 0
Brazil
State/province [74] 0 0
Belo Horizonte
Country [75] 0 0
Brazil
State/province [75] 0 0
Blumenau
Country [76] 0 0
Brazil
State/province [76] 0 0
Brasília
Country [77] 0 0
Brazil
State/province [77] 0 0
Curitiba
Country [78] 0 0
Brazil
State/province [78] 0 0
Fortaleza
Country [79] 0 0
Brazil
State/province [79] 0 0
Goiânia
Country [80] 0 0
Brazil
State/province [80] 0 0
Itajai
Country [81] 0 0
Brazil
State/province [81] 0 0
Joao Pessoa
Country [82] 0 0
Brazil
State/province [82] 0 0
Natal
Country [83] 0 0
Brazil
State/province [83] 0 0
Porto Alegre
Country [84] 0 0
Brazil
State/province [84] 0 0
Porto Velho
Country [85] 0 0
Brazil
State/province [85] 0 0
Pouso Alegre
Country [86] 0 0
Brazil
State/province [86] 0 0
Recife
Country [87] 0 0
Brazil
State/province [87] 0 0
Ribeirão Preto
Country [88] 0 0
Brazil
State/province [88] 0 0
Rio de Janeiro
Country [89] 0 0
Brazil
State/province [89] 0 0
Rio De Janeiro
Country [90] 0 0
Brazil
State/province [90] 0 0
Salvador
Country [91] 0 0
Brazil
State/province [91] 0 0
Santo André
Country [92] 0 0
Brazil
State/province [92] 0 0
Sao Paulo
Country [93] 0 0
Brazil
State/province [93] 0 0
São Paulo
Country [94] 0 0
Brazil
State/province [94] 0 0
Taubaté
Country [95] 0 0
Brazil
State/province [95] 0 0
Teresina
Country [96] 0 0
Brazil
State/province [96] 0 0
Tres Lagoas
Country [97] 0 0
Brazil
State/province [97] 0 0
Vitória
Country [98] 0 0
Bulgaria
State/province [98] 0 0
Dobrich
Country [99] 0 0
Bulgaria
State/province [99] 0 0
Haskovo
Country [100] 0 0
Bulgaria
State/province [100] 0 0
Plovdiv
Country [101] 0 0
Bulgaria
State/province [101] 0 0
Shumen
Country [102] 0 0
Bulgaria
State/province [102] 0 0
Sofia
Country [103] 0 0
Bulgaria
State/province [103] 0 0
Varna
Country [104] 0 0
Bulgaria
State/province [104] 0 0
Vratsa
Country [105] 0 0
Canada
State/province [105] 0 0
Alberta
Country [106] 0 0
Canada
State/province [106] 0 0
British Columbia
Country [107] 0 0
Canada
State/province [107] 0 0
Nova Scotia
Country [108] 0 0
Canada
State/province [108] 0 0
Ontario
Country [109] 0 0
Canada
State/province [109] 0 0
Quebec
Country [110] 0 0
Canada
State/province [110] 0 0
Saskatchewan
Country [111] 0 0
Chile
State/province [111] 0 0
Concepcion
Country [112] 0 0
Chile
State/province [112] 0 0
La Serena
Country [113] 0 0
Chile
State/province [113] 0 0
Providencia
Country [114] 0 0
Chile
State/province [114] 0 0
Puerto Montt
Country [115] 0 0
Chile
State/province [115] 0 0
Santiago
Country [116] 0 0
Chile
State/province [116] 0 0
Temuco
Country [117] 0 0
Chile
State/province [117] 0 0
Vina del Mar
Country [118] 0 0
China
State/province [118] 0 0
Baoding
Country [119] 0 0
China
State/province [119] 0 0
Beijing
Country [120] 0 0
China
State/province [120] 0 0
Bengbu
Country [121] 0 0
China
State/province [121] 0 0
Binzhou
Country [122] 0 0
China
State/province [122] 0 0
Cangzhou
Country [123] 0 0
China
State/province [123] 0 0
Changchun
Country [124] 0 0
China
State/province [124] 0 0
Changsha
Country [125] 0 0
China
State/province [125] 0 0
Chengdu
Country [126] 0 0
China
State/province [126] 0 0
Chifeng
Country [127] 0 0
China
State/province [127] 0 0
Dalian
Country [128] 0 0
China
State/province [128] 0 0
Foshan
Country [129] 0 0
China
State/province [129] 0 0
Fuzhou
Country [130] 0 0
China
State/province [130] 0 0
Guangzhou Shi
Country [131] 0 0
China
State/province [131] 0 0
Guangzhou
Country [132] 0 0
China
State/province [132] 0 0
Haikou
Country [133] 0 0
China
State/province [133] 0 0
Hangzhou
Country [134] 0 0
China
State/province [134] 0 0
Harbin
Country [135] 0 0
China
State/province [135] 0 0
Hefei
Country [136] 0 0
China
State/province [136] 0 0
Hohhot
Country [137] 0 0
China
State/province [137] 0 0
Huizhou
Country [138] 0 0
China
State/province [138] 0 0
Jinzhou
Country [139] 0 0
China
State/province [139] 0 0
Lanzhou
Country [140] 0 0
China
State/province [140] 0 0
Linyi
Country [141] 0 0
China
State/province [141] 0 0
Liuzhou
Country [142] 0 0
China
State/province [142] 0 0
Nanchang
Country [143] 0 0
China
State/province [143] 0 0
Nanjing
Country [144] 0 0
China
State/province [144] 0 0
Nanning
Country [145] 0 0
China
State/province [145] 0 0
Nantong
Country [146] 0 0
China
State/province [146] 0 0
Neijiang
Country [147] 0 0
China
State/province [147] 0 0
Shandong
Country [148] 0 0
China
State/province [148] 0 0
Shangqiu
Country [149] 0 0
China
State/province [149] 0 0
Shantou
Country [150] 0 0
China
State/province [150] 0 0
Shaoguan Shi
Country [151] 0 0
China
State/province [151] 0 0
Shenyang
Country [152] 0 0
China
State/province [152] 0 0
Shenzhen
Country [153] 0 0
China
State/province [153] 0 0
Shijiahzhuang
Country [154] 0 0
China
State/province [154] 0 0
Suining Shi
Country [155] 0 0
China
State/province [155] 0 0
Suzhou
Country [156] 0 0
China
State/province [156] 0 0
Taizhou
Country [157] 0 0
China
State/province [157] 0 0
Tianjin
Country [158] 0 0
China
State/province [158] 0 0
WeiFang
Country [159] 0 0
China
State/province [159] 0 0
Wuhan
Country [160] 0 0
China
State/province [160] 0 0
Xiangfan
Country [161] 0 0
China
State/province [161] 0 0
Xian
Country [162] 0 0
China
State/province [162] 0 0
Xinxiang
Country [163] 0 0
China
State/province [163] 0 0
Xuzhou
Country [164] 0 0
China
State/province [164] 0 0
Zunyi
Country [165] 0 0
Colombia
State/province [165] 0 0
Barranquilla
Country [166] 0 0
Colombia
State/province [166] 0 0
Bogota
Country [167] 0 0
Colombia
State/province [167] 0 0
Cali
Country [168] 0 0
Colombia
State/province [168] 0 0
Medellin
Country [169] 0 0
Colombia
State/province [169] 0 0
Monteria
Country [170] 0 0
Colombia
State/province [170] 0 0
Valledupar
Country [171] 0 0
Croatia
State/province [171] 0 0
Rijeka
Country [172] 0 0
Croatia
State/province [172] 0 0
Zadar
Country [173] 0 0
Croatia
State/province [173] 0 0
Zagreb
Country [174] 0 0
Czechia
State/province [174] 0 0
Brno
Country [175] 0 0
Czechia
State/province [175] 0 0
Horovice
Country [176] 0 0
Czechia
State/province [176] 0 0
Liberec
Country [177] 0 0
Czechia
State/province [177] 0 0
Pardubice
Country [178] 0 0
Czechia
State/province [178] 0 0
Praha 5
Country [179] 0 0
Estonia
State/province [179] 0 0
Tallinn
Country [180] 0 0
Estonia
State/province [180] 0 0
Tallin
Country [181] 0 0
Estonia
State/province [181] 0 0
Tartu
Country [182] 0 0
France
State/province [182] 0 0
Angers
Country [183] 0 0
France
State/province [183] 0 0
Bordeaux
Country [184] 0 0
France
State/province [184] 0 0
Caen cedex 05
Country [185] 0 0
France
State/province [185] 0 0
Clermont-Ferrand
Country [186] 0 0
France
State/province [186] 0 0
Dijon
Country [187] 0 0
France
State/province [187] 0 0
Epagny Metz-Tessy
Country [188] 0 0
France
State/province [188] 0 0
Lille
Country [189] 0 0
France
State/province [189] 0 0
Lyon
Country [190] 0 0
France
State/province [190] 0 0
Marseille
Country [191] 0 0
France
State/province [191] 0 0
Montpellier
Country [192] 0 0
France
State/province [192] 0 0
Nantes
Country [193] 0 0
France
State/province [193] 0 0
Nimes
Country [194] 0 0
France
State/province [194] 0 0
Pierre Benite
Country [195] 0 0
France
State/province [195] 0 0
Plerin SUR MER
Country [196] 0 0
France
State/province [196] 0 0
Rennes
Country [197] 0 0
France
State/province [197] 0 0
Rouen
Country [198] 0 0
France
State/province [198] 0 0
Saint Herblain
Country [199] 0 0
France
State/province [199] 0 0
Saint-Priest-En-Jarez
Country [200] 0 0
France
State/province [200] 0 0
Strasbourg
Country [201] 0 0
France
State/province [201] 0 0
Toulouse
Country [202] 0 0
France
State/province [202] 0 0
Vandoeuvre les Nancy
Country [203] 0 0
France
State/province [203] 0 0
Villejuif Cedex
Country [204] 0 0
Georgia
State/province [204] 0 0
Batumi
Country [205] 0 0
Georgia
State/province [205] 0 0
Tbilisi
Country [206] 0 0
Germany
State/province [206] 0 0
Aachen
Country [207] 0 0
Germany
State/province [207] 0 0
Berlin
Country [208] 0 0
Germany
State/province [208] 0 0
Darmstadt
Country [209] 0 0
Germany
State/province [209] 0 0
Deggendorf
Country [210] 0 0
Germany
State/province [210] 0 0
Dessau-Rosslau
Country [211] 0 0
Germany
State/province [211] 0 0
Dresden
Country [212] 0 0
Germany
State/province [212] 0 0
Düsseldorf
Country [213] 0 0
Germany
State/province [213] 0 0
Essen
Country [214] 0 0
Germany
State/province [214] 0 0
Freudenstadt
Country [215] 0 0
Germany
State/province [215] 0 0
Georgsmarienhuette
Country [216] 0 0
Germany
State/province [216] 0 0
Hamburg
Country [217] 0 0
Germany
State/province [217] 0 0
Hamm
Country [218] 0 0
Germany
State/province [218] 0 0
Hanau
Country [219] 0 0
Germany
State/province [219] 0 0
Hannover
Country [220] 0 0
Germany
State/province [220] 0 0
Heidelberg
Country [221] 0 0
Germany
State/province [221] 0 0
Karlsruhe
Country [222] 0 0
Germany
State/province [222] 0 0
Koblenz
Country [223] 0 0
Germany
State/province [223] 0 0
Köln
Country [224] 0 0
Germany
State/province [224] 0 0
Mainz
Country [225] 0 0
Germany
State/province [225] 0 0
Nurtingen
Country [226] 0 0
Germany
State/province [226] 0 0
Offenburg
Country [227] 0 0
Germany
State/province [227] 0 0
Rostock
Country [228] 0 0
Germany
State/province [228] 0 0
Saarbrücken
Country [229] 0 0
Germany
State/province [229] 0 0
Schweinfurt
Country [230] 0 0
Germany
State/province [230] 0 0
Speyer
Country [231] 0 0
Germany
State/province [231] 0 0
Torgau
Country [232] 0 0
Germany
State/province [232] 0 0
Wiesbaden
Country [233] 0 0
Germany
State/province [233] 0 0
Witten
Country [234] 0 0
Germany
State/province [234] 0 0
Worms
Country [235] 0 0
Germany
State/province [235] 0 0
Wuppertal
Country [236] 0 0
Greece
State/province [236] 0 0
Athens
Country [237] 0 0
Greece
State/province [237] 0 0
Heraklion
Country [238] 0 0
Greece
State/province [238] 0 0
Ioannina
Country [239] 0 0
Greece
State/province [239] 0 0
Larissa
Country [240] 0 0
Greece
State/province [240] 0 0
Marousi
Country [241] 0 0
Greece
State/province [241] 0 0
Piraeus
Country [242] 0 0
Greece
State/province [242] 0 0
Rio
Country [243] 0 0
Greece
State/province [243] 0 0
Thessaloniki
Country [244] 0 0
Hungary
State/province [244] 0 0
Budapest
Country [245] 0 0
Hungary
State/province [245] 0 0
Debrecen
Country [246] 0 0
Hungary
State/province [246] 0 0
Gyula
Country [247] 0 0
Hungary
State/province [247] 0 0
Gyor
Country [248] 0 0
Hungary
State/province [248] 0 0
Kaposvár
Country [249] 0 0
Hungary
State/province [249] 0 0
Kecskemét
Country [250] 0 0
Hungary
State/province [250] 0 0
Miskolc
Country [251] 0 0
Hungary
State/province [251] 0 0
Nyíregyháza
Country [252] 0 0
Hungary
State/province [252] 0 0
Salgotarjan
Country [253] 0 0
Hungary
State/province [253] 0 0
Szekszárd
Country [254] 0 0
Hungary
State/province [254] 0 0
Zalaegerszeg
Country [255] 0 0
India
State/province [255] 0 0
Ansari Nagar
Country [256] 0 0
India
State/province [256] 0 0
Bangalore
Country [257] 0 0
India
State/province [257] 0 0
Belgavi
Country [258] 0 0
India
State/province [258] 0 0
Dehradun
Country [259] 0 0
India
State/province [259] 0 0
Delhi
Country [260] 0 0
India
State/province [260] 0 0
Dhanvantari Nagar
Country [261] 0 0
India
State/province [261] 0 0
Gurgaon
Country [262] 0 0
India
State/province [262] 0 0
Hyderabad
Country [263] 0 0
India
State/province [263] 0 0
JAipur
Country [264] 0 0
India
State/province [264] 0 0
Kanpur
Country [265] 0 0
India
State/province [265] 0 0
Kolkata
Country [266] 0 0
India
State/province [266] 0 0
Kozhikode
Country [267] 0 0
India
State/province [267] 0 0
Mumbai
Country [268] 0 0
India
State/province [268] 0 0
Mysuru
Country [269] 0 0
India
State/province [269] 0 0
Nagpur
Country [270] 0 0
India
State/province [270] 0 0
Nashik
Country [271] 0 0
India
State/province [271] 0 0
New Delhi
Country [272] 0 0
India
State/province [272] 0 0
Surat
Country [273] 0 0
Ireland
State/province [273] 0 0
Cork
Country [274] 0 0
Ireland
State/province [274] 0 0
Dublin
Country [275] 0 0
Ireland
State/province [275] 0 0
Galway
Country [276] 0 0
Ireland
State/province [276] 0 0
Waterford
Country [277] 0 0
Israel
State/province [277] 0 0
Afula
Country [278] 0 0
Israel
State/province [278] 0 0
Ashdod
Country [279] 0 0
Israel
State/province [279] 0 0
Beer Sheva
Country [280] 0 0
Israel
State/province [280] 0 0
Haifa
Country [281] 0 0
Israel
State/province [281] 0 0
Jerusalem
Country [282] 0 0
Israel
State/province [282] 0 0
Kfar Saba
Country [283] 0 0
Israel
State/province [283] 0 0
Nahariya
Country [284] 0 0
Israel
State/province [284] 0 0
Ramat Gan
Country [285] 0 0
Italy
State/province [285] 0 0
Bologna
Country [286] 0 0
Italy
State/province [286] 0 0
Brindisi
Country [287] 0 0
Italy
State/province [287] 0 0
Firenze
Country [288] 0 0
Italy
State/province [288] 0 0
Genoa
Country [289] 0 0
Italy
State/province [289] 0 0
Milano
Country [290] 0 0
Italy
State/province [290] 0 0
Milan
Country [291] 0 0
Italy
State/province [291] 0 0
Misterbianco
Country [292] 0 0
Italy
State/province [292] 0 0
Modena
Country [293] 0 0
Italy
State/province [293] 0 0
Monza
Country [294] 0 0
Italy
State/province [294] 0 0
Napoli
Country [295] 0 0
Italy
State/province [295] 0 0
Novara
Country [296] 0 0
Italy
State/province [296] 0 0
Padova
Country [297] 0 0
Italy
State/province [297] 0 0
Roma
Country [298] 0 0
Italy
State/province [298] 0 0
Rozzano
Country [299] 0 0
Italy
State/province [299] 0 0
Torino
Country [300] 0 0
Italy
State/province [300] 0 0
Trento
Country [301] 0 0
Japan
State/province [301] 0 0
Chiba-shi
Country [302] 0 0
Japan
State/province [302] 0 0
Fukuoka-shi
Country [303] 0 0
Japan
State/province [303] 0 0
Fukushima-shi
Country [304] 0 0
Japan
State/province [304] 0 0
Hirakata-shi
Country [305] 0 0
Japan
State/province [305] 0 0
Hiroshima-shi
Country [306] 0 0
Japan
State/province [306] 0 0
Iruma-Gun
Country [307] 0 0
Japan
State/province [307] 0 0
Isehara-shi
Country [308] 0 0
Japan
State/province [308] 0 0
Kagoshima-shi
Country [309] 0 0
Japan
State/province [309] 0 0
Kashiwa
Country [310] 0 0
Japan
State/province [310] 0 0
Koto-ku
Country [311] 0 0
Japan
State/province [311] 0 0
Kumamoto-shi
Country [312] 0 0
Japan
State/province [312] 0 0
Kurume-shi
Country [313] 0 0
Japan
State/province [313] 0 0
Kyoto-shi
Country [314] 0 0
Japan
State/province [314] 0 0
Matsuyama-shi
Country [315] 0 0
Japan
State/province [315] 0 0
Nagoya-shi
Country [316] 0 0
Japan
State/province [316] 0 0
Niigata-shi
Country [317] 0 0
Japan
State/province [317] 0 0
Osaka-shi
Country [318] 0 0
Japan
State/province [318] 0 0
Ota-shi
Country [319] 0 0
Japan
State/province [319] 0 0
Sapporo-shi
Country [320] 0 0
Japan
State/province [320] 0 0
Sendai-shi
Country [321] 0 0
Japan
State/province [321] 0 0
Shinagawa-ku
Country [322] 0 0
Japan
State/province [322] 0 0
Suita-shi
Country [323] 0 0
Japan
State/province [323] 0 0
Sunto-gun
Country [324] 0 0
Japan
State/province [324] 0 0
Takasaki-shi
Country [325] 0 0
Japan
State/province [325] 0 0
Tsu-shi
Country [326] 0 0
Japan
State/province [326] 0 0
Yokohama-shi
Country [327] 0 0
Korea, Republic of
State/province [327] 0 0
Cheonan-si
Country [328] 0 0
Korea, Republic of
State/province [328] 0 0
Daegu
Country [329] 0 0
Korea, Republic of
State/province [329] 0 0
Goyang-si
Country [330] 0 0
Korea, Republic of
State/province [330] 0 0
Seongnam-si
Country [331] 0 0
Korea, Republic of
State/province [331] 0 0
Seoul
Country [332] 0 0
Malaysia
State/province [332] 0 0
Johor Bahru
Country [333] 0 0
Malaysia
State/province [333] 0 0
Kota Bharu
Country [334] 0 0
Malaysia
State/province [334] 0 0
Kuala Lumpur
Country [335] 0 0
Malaysia
State/province [335] 0 0
Kuching
Country [336] 0 0
Malaysia
State/province [336] 0 0
Melaka
Country [337] 0 0
Malaysia
State/province [337] 0 0
Pulau Pinang
Country [338] 0 0
Mexico
State/province [338] 0 0
Alc. Cuauhtémoc
Country [339] 0 0
Mexico
State/province [339] 0 0
Cancún
Country [340] 0 0
Mexico
State/province [340] 0 0
Colonia Lindavista
Country [341] 0 0
Mexico
State/province [341] 0 0
Estado de México
Country [342] 0 0
Mexico
State/province [342] 0 0
Mexico
Country [343] 0 0
Mexico
State/province [343] 0 0
Monterrey
Country [344] 0 0
Mexico
State/province [344] 0 0
Mérida
Country [345] 0 0
Mexico
State/province [345] 0 0
San Luis Potosí
Country [346] 0 0
Mexico
State/province [346] 0 0
Tuxtla Gutiérrez
Country [347] 0 0
Mexico
State/province [347] 0 0
Veracruz
Country [348] 0 0
New Zealand
State/province [348] 0 0
Auckland
Country [349] 0 0
New Zealand
State/province [349] 0 0
Hamilton
Country [350] 0 0
New Zealand
State/province [350] 0 0
Palmerston North
Country [351] 0 0
Peru
State/province [351] 0 0
Arequipa
Country [352] 0 0
Peru
State/province [352] 0 0
La Libertad
Country [353] 0 0
Peru
State/province [353] 0 0
Lima
Country [354] 0 0
Peru
State/province [354] 0 0
San Isidro
Country [355] 0 0
Peru
State/province [355] 0 0
Trujillo
Country [356] 0 0
Philippines
State/province [356] 0 0
Bacolod
Country [357] 0 0
Philippines
State/province [357] 0 0
Cebu City
Country [358] 0 0
Philippines
State/province [358] 0 0
Iloilo City
Country [359] 0 0
Philippines
State/province [359] 0 0
Manila
Country [360] 0 0
Philippines
State/province [360] 0 0
Quezon
Country [361] 0 0
Poland
State/province [361] 0 0
Biala Podlaska
Country [362] 0 0
Poland
State/province [362] 0 0
Bialystok
Country [363] 0 0
Poland
State/province [363] 0 0
Bydgoszcz
Country [364] 0 0
Poland
State/province [364] 0 0
Gdansk
Country [365] 0 0
Poland
State/province [365] 0 0
Gdynia
Country [366] 0 0
Poland
State/province [366] 0 0
Grudziadz
Country [367] 0 0
Poland
State/province [367] 0 0
Koszalin
Country [368] 0 0
Poland
State/province [368] 0 0
Kraków
Country [369] 0 0
Poland
State/province [369] 0 0
Lublin
Country [370] 0 0
Poland
State/province [370] 0 0
Opole
Country [371] 0 0
Poland
State/province [371] 0 0
Poznan
Country [372] 0 0
Poland
State/province [372] 0 0
Racibórz
Country [373] 0 0
Poland
State/province [373] 0 0
Rzeszow
Country [374] 0 0
Poland
State/province [374] 0 0
Rzeszów
Country [375] 0 0
Poland
State/province [375] 0 0
Szczecin
Country [376] 0 0
Poland
State/province [376] 0 0
Tomaszów Mazowiecki
Country [377] 0 0
Poland
State/province [377] 0 0
Warszawa
Country [378] 0 0
Poland
State/province [378] 0 0
Wroclaw
Country [379] 0 0
Poland
State/province [379] 0 0
Lódz
Country [380] 0 0
Portugal
State/province [380] 0 0
Amadora
Country [381] 0 0
Portugal
State/province [381] 0 0
Braga
Country [382] 0 0
Portugal
State/province [382] 0 0
Lisboa
Country [383] 0 0
Portugal
State/province [383] 0 0
Matosinhos
Country [384] 0 0
Portugal
State/province [384] 0 0
Porto
Country [385] 0 0
Portugal
State/province [385] 0 0
Viana do Castelo
Country [386] 0 0
Portugal
State/province [386] 0 0
Vila Nova de Gaia
Country [387] 0 0
Portugal
State/province [387] 0 0
Vila Real
Country [388] 0 0
Puerto Rico
State/province [388] 0 0
Rio Piedras
Country [389] 0 0
Romania
State/province [389] 0 0
Bucuresti
Country [390] 0 0
Romania
State/province [390] 0 0
Cluj Napoca
Country [391] 0 0
Romania
State/province [391] 0 0
Cluj-Napoca
Country [392] 0 0
Romania
State/province [392] 0 0
Craiova
Country [393] 0 0
Romania
State/province [393] 0 0
Floresti
Country [394] 0 0
Romania
State/province [394] 0 0
Iasi
Country [395] 0 0
Romania
State/province [395] 0 0
Oradea
Country [396] 0 0
Romania
State/province [396] 0 0
Otopeni
Country [397] 0 0
Romania
State/province [397] 0 0
Ovidiu
Country [398] 0 0
Romania
State/province [398] 0 0
Pitesti
Country [399] 0 0
Romania
State/province [399] 0 0
Sibiu
Country [400] 0 0
Romania
State/province [400] 0 0
Timisoara
Country [401] 0 0
Saudi Arabia
State/province [401] 0 0
Riyadh/MENA
Country [402] 0 0
Saudi Arabia
State/province [402] 0 0
Riyadh
Country [403] 0 0
Serbia
State/province [403] 0 0
Belgrade
Country [404] 0 0
Serbia
State/province [404] 0 0
Belgrad
Country [405] 0 0
Serbia
State/province [405] 0 0
Beograd
Country [406] 0 0
Serbia
State/province [406] 0 0
Kragujevac
Country [407] 0 0
Serbia
State/province [407] 0 0
Nis
Country [408] 0 0
Serbia
State/province [408] 0 0
Novi Sad
Country [409] 0 0
Serbia
State/province [409] 0 0
Valjevo
Country [410] 0 0
Serbia
State/province [410] 0 0
Zrenjanin
Country [411] 0 0
South Africa
State/province [411] 0 0
Amanzimtoti
Country [412] 0 0
South Africa
State/province [412] 0 0
Bloemfontein
Country [413] 0 0
South Africa
State/province [413] 0 0
Cape Town
Country [414] 0 0
South Africa
State/province [414] 0 0
George
Country [415] 0 0
South Africa
State/province [415] 0 0
Johannesburg
Country [416] 0 0
South Africa
State/province [416] 0 0
Pietermaritzburg
Country [417] 0 0
South Africa
State/province [417] 0 0
Port Elizabeth
Country [418] 0 0
South Africa
State/province [418] 0 0
Pretoria
Country [419] 0 0
Spain
State/province [419] 0 0
A Coruña
Country [420] 0 0
Spain
State/province [420] 0 0
Albacete
Country [421] 0 0
Spain
State/province [421] 0 0
Alicante
Country [422] 0 0
Spain
State/province [422] 0 0
Badalona
Country [423] 0 0
Spain
State/province [423] 0 0
Barakaldo
Country [424] 0 0
Spain
State/province [424] 0 0
Barcelona
Country [425] 0 0
Spain
State/province [425] 0 0
Burgos
Country [426] 0 0
Spain
State/province [426] 0 0
Caceres
Country [427] 0 0
Spain
State/province [427] 0 0
Castello de la Plana
Country [428] 0 0
Spain
State/province [428] 0 0
Cordoba
Country [429] 0 0
Spain
State/province [429] 0 0
El Palmar
Country [430] 0 0
Spain
State/province [430] 0 0
Elche(Alicante)
Country [431] 0 0
Spain
State/province [431] 0 0
Fuenlabrada
Country [432] 0 0
Spain
State/province [432] 0 0
Granada
Country [433] 0 0
Spain
State/province [433] 0 0
Jerez de la Frontera
Country [434] 0 0
Spain
State/province [434] 0 0
La Coruña
Country [435] 0 0
Spain
State/province [435] 0 0
La Laguna (Tenerife)
Country [436] 0 0
Spain
State/province [436] 0 0
Leon
Country [437] 0 0
Spain
State/province [437] 0 0
Lérida
Country [438] 0 0
Spain
State/province [438] 0 0
Madrid
Country [439] 0 0
Spain
State/province [439] 0 0
Malaga
Country [440] 0 0
Spain
State/province [440] 0 0
Manresa
Country [441] 0 0
Spain
State/province [441] 0 0
Murcia
Country [442] 0 0
Spain
State/province [442] 0 0
Málaga
Country [443] 0 0
Spain
State/province [443] 0 0
Palma de Mallorca
Country [444] 0 0
Spain
State/province [444] 0 0
Reus,Tarragona
Country [445] 0 0
Spain
State/province [445] 0 0
Sabadell
Country [446] 0 0
Spain
State/province [446] 0 0
Salamanca
Country [447] 0 0
Spain
State/province [447] 0 0
San Sebastian
Country [448] 0 0
Spain
State/province [448] 0 0
Sant Joan Despí
Country [449] 0 0
Spain
State/province [449] 0 0
Sevilla
Country [450] 0 0
Spain
State/province [450] 0 0
Toledo
Country [451] 0 0
Spain
State/province [451] 0 0
Valencia
Country [452] 0 0
Spain
State/province [452] 0 0
Vigo
Country [453] 0 0
Spain
State/province [453] 0 0
Zaragoza
Country [454] 0 0
Switzerland
State/province [454] 0 0
Baden
Country [455] 0 0
Switzerland
State/province [455] 0 0
Basel
Country [456] 0 0
Switzerland
State/province [456] 0 0
Bellinzona
Country [457] 0 0
Switzerland
State/province [457] 0 0
Chur
Country [458] 0 0
Switzerland
State/province [458] 0 0
Frauenfeld
Country [459] 0 0
Switzerland
State/province [459] 0 0
La Chaux-De-Fonds
Country [460] 0 0
Switzerland
State/province [460] 0 0
Lausanne
Country [461] 0 0
Switzerland
State/province [461] 0 0
Luzern
Country [462] 0 0
Switzerland
State/province [462] 0 0
St. Gallen
Country [463] 0 0
Switzerland
State/province [463] 0 0
Winterthur
Country [464] 0 0
Switzerland
State/province [464] 0 0
Zürich
Country [465] 0 0
Taiwan
State/province [465] 0 0
Hsinchu
Country [466] 0 0
Taiwan
State/province [466] 0 0
Kaohsiung
Country [467] 0 0
Taiwan
State/province [467] 0 0
Taichung
Country [468] 0 0
Taiwan
State/province [468] 0 0
Tainan
Country [469] 0 0
Taiwan
State/province [469] 0 0
Taipei
Country [470] 0 0
Taiwan
State/province [470] 0 0
Yong Kang City
Country [471] 0 0
Thailand
State/province [471] 0 0
Bangkok
Country [472] 0 0
Thailand
State/province [472] 0 0
Hat Yai
Country [473] 0 0
Thailand
State/province [473] 0 0
Khon Kaen
Country [474] 0 0
Turkey
State/province [474] 0 0
Ankara
Country [475] 0 0
Turkey
State/province [475] 0 0
Antalya
Country [476] 0 0
Turkey
State/province [476] 0 0
Bursa
Country [477] 0 0
Turkey
State/province [477] 0 0
Cigli
Country [478] 0 0
Turkey
State/province [478] 0 0
Edirne
Country [479] 0 0
Turkey
State/province [479] 0 0
Istanbul
Country [480] 0 0
Turkey
State/province [480] 0 0
Karsiyaka
Country [481] 0 0
Turkey
State/province [481] 0 0
Malatya
Country [482] 0 0
Turkey
State/province [482] 0 0
Samsun
Country [483] 0 0
Turkey
State/province [483] 0 0
Çankaya
Country [484] 0 0
United Arab Emirates
State/province [484] 0 0
Abu Dhabi
Country [485] 0 0
United Arab Emirates
State/province [485] 0 0
Al Ain
Country [486] 0 0
United Arab Emirates
State/province [486] 0 0
Dubai
Country [487] 0 0
United Kingdom
State/province [487] 0 0
Aberdeen
Country [488] 0 0
United Kingdom
State/province [488] 0 0
Bath
Country [489] 0 0
United Kingdom
State/province [489] 0 0
Brighton
Country [490] 0 0
United Kingdom
State/province [490] 0 0
Cambridge
Country [491] 0 0
United Kingdom
State/province [491] 0 0
Guilford
Country [492] 0 0
United Kingdom
State/province [492] 0 0
Ipswich
Country [493] 0 0
United Kingdom
State/province [493] 0 0
Lancaster
Country [494] 0 0
United Kingdom
State/province [494] 0 0
Leeds
Country [495] 0 0
United Kingdom
State/province [495] 0 0
Leicester
Country [496] 0 0
United Kingdom
State/province [496] 0 0
Liverpool
Country [497] 0 0
United Kingdom
State/province [497] 0 0
London
Country [498] 0 0
United Kingdom
State/province [498] 0 0
Manchester
Country [499] 0 0
United Kingdom
State/province [499] 0 0
Northampton
Country [500] 0 0
United Kingdom
State/province [500] 0 0
Oxford
Country [501] 0 0
United Kingdom
State/province [501] 0 0
Reading
Country [502] 0 0
United Kingdom
State/province [502] 0 0
Shrewsbury
Country [503] 0 0
United Kingdom
State/province [503] 0 0
Stockton
Country [504] 0 0
United Kingdom
State/province [504] 0 0
Sutton In Ashfield
Country [505] 0 0
United Kingdom
State/province [505] 0 0
Sutton
Country [506] 0 0
United Kingdom
State/province [506] 0 0
Taunton
Country [507] 0 0
United Kingdom
State/province [507] 0 0
Warwick
Country [508] 0 0
United Kingdom
State/province [508] 0 0
Whitchurch

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
AstraZeneca
Address
Country
Other collaborator category [1] 0 0
Other
Name [1] 0 0
Austrian Breast and Colorectal Cancer Study Group (ABCSG)
Address [1] 0 0
Country [1] 0 0

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
AstraZeneca Clinical Study Information Center
Address 0 0
Country 0 0
Phone 0 0
1-877-240-9479
Fax 0 0
Email 0 0
information.center@astrazeneca.com
Contact person for scientific queries

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
What data in particular will be shared?
Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Supporting document/s available: Study protocol, Statistical analysis plan (SAP)
When will data be available (start and end dates)?
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please refer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Available to whom?
When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool. Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure
Available for what types of analyses?
How or where can data be obtained?
IPD available at link: https://astrazenecagroup-dt.pharmacm.com/DT/Home


What supporting documents are/will be available?

No Supporting Document Provided



Results publications and other study-related documents

No documents have been uploaded by study researchers.


Results not provided in https://clinicaltrials.gov/study/NCT05952557