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Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
Periodontal Disease and Cardiovascular Disease
Scientific title
Periodontal Disease and Cardiovascular Disease
Secondary ID [1] 0 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Periodontal Diseases 0 0
Condition category
Condition code
Oral and Gastrointestinal 0 0 0 0
Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
Infection 0 0 0 0
Other infectious diseases

Study type
Description of intervention(s) / exposure
Treatment: Drugs - Triclosan
Treatment: Drugs - Fluoride
Treatment: Drugs - Fluoride

Active Comparator: A -

Placebo Comparator: B -

Treatment: Drugs: Triclosan
Brush twice daily

Treatment: Drugs: Fluoride
Brush twice daily

Treatment: Drugs: Fluoride
Brush twice daily

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Primary outcome [1] 0 0
Periodontal disease
Timepoint [1] 0 0
3-5 Years

Key inclusion criteria
- A minimum of 12 uncrowned teeth other than 3rd molars

- Age 18 to 75 years

- Informed consent
Minimum age
18 Years
Maximum age
75 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- Prosthetic heart valves

- Prosthetic joint replacement

- Previous infective endocarditis

- Requirement for antibiotic cover for dental treatment

- Current treatment with warfarin

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s

The people analysing the results/data
Intervention assignment
Other design features
Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Unknown status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
Discipline of Medicine - Chermside
Recruitment postcode(s) [1] 0 0
- Chermside

Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
Colgate Palmolive

Ethics approval
Ethics application status

Brief summary
To access the influence of triclosan dentifrice on the progression of periodontal disease in
patients with coronary heart disease.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 0 0
Gregory Seymour, BDS
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Summary results
For IPD and results data, please see