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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/ct2/show/NCT03911505




Registration number
NCT03911505
Ethics application status
Date submitted
9/04/2019
Date registered
11/04/2019
Date last updated
5/06/2024

Titles & IDs
Public title
ZIP Study-OL Study of Safety, PK, Efficacy, PD, Immunogenicity of ATB200/AT2221 in Pediatrics Aged 0 to < 18 y.o. w/LOPD
Scientific title
An Open-label Study of the Safety, Pharmacokinetics, Efficacy, Pharmacodynamics, and Immunogenicity of Cipaglucosidase Alfa/Miglustat in Pediatric Subjects Aged 0 to < 18 Years With Late-onset Pompe Disease
Secondary ID [1] 0 0
ATB200-04
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Pompe Disease (Late-onset) 0 0
Condition category
Condition code
Metabolic and Endocrine 0 0 0 0
Metabolic disorders
Metabolic and Endocrine 0 0 0 0
Other metabolic disorders
Human Genetics and Inherited Disorders 0 0 0 0
Other human genetics and inherited disorders

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Other interventions - Cipaglucosidase Alfa
Treatment: Drugs - Miglustat

Experimental: Cipaglucosidase Alfa (ATB200)/Miglustat(AT2221) - Participants received Cipaglucosidase Alfa (ATB200) co-administered with Miglustat (AT2221) capsule


Other interventions: Cipaglucosidase Alfa
Enzyme Replacement Therapy via intravenous infusion

Treatment: Drugs: Miglustat
Participants received Cipaglucosidase Alfa (ATB200) co-administered with Miglustat(AT2221)
Intervention code [1] 0 0
Other interventions
Intervention code [2] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Incidence of treatment-emergent adverse events (TEAEs) from baseline
Timepoint [1] 0 0
52 weeks
Secondary outcome [1] 0 0
Assessment of pharmacokinetic parameters
Timepoint [1] 0 0
52 weeks

Eligibility
Key inclusion criteria
1. Male or female subjects (ERT-naïve [have never received a dose of rhGAA] or
ERT-experienced [have received rhGAA every 2 weeks for at least 6 months immediately
before enrollment, and if ERT dosage has been modified, must have been on the modified
dosage for at least 3 months before enrollment]) diagnosed with LOPD who are aged 12
to <18 years at screening (Cohort 1 only) or aged 0 months to < 12 years at screening
(Cohort 2 only)

2. Subject weighs = 115 kg. (Cohort 1 Only)

3. Subject must have a diagnosis of LOPD based on documentation as defined in study
protocol

4. If of reproductive potential and if sexually active, female and male subjects agree to
use a highly effective method of contraception throughout the duration of the study
and for up to 90 days after their last dose of Cipaglucosidase Alfa/Miglustat

5. Subject has a sitting forced vital capacity (FVC) = 30% of the predicted value for
healthy Adolescents at screening (Cohort 1 only)

6. Subject (aged 12 to <18 years; Cohort 1) performs one 6-Minute Walk Test (6MWT) (= 75
meters) at screening that is valid, as determined by the clinical evaluator, or
subject (aged = 5 to < 12 years; Cohort 2) performs one 6MWT (= 40 meters) at
screening that is valid, as determined by the clinical evaluator
Minimum age
0 Years
Maximum age
17 Years
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
1. Subject has received any investigational/experimental drug, oral anabolic steroid or
derivative, biologic, or device within 30 days or 5 half-lives of the therapy or
treatment, whichever is longer, before screening

2. Subject has received treatment with prohibited medications within 30 days of screening

3. Subject has received any gene therapy at any time

4. Subject has any intercurrent illness or condition at screening or baseline that may
preclude the subject from fulfilling the protocol requirements or suggests to the
investigator and/or the medical monitor that the potential subject may have an
unacceptable risk by participating in this study

5. Subject has a hypersensitivity to any of the excipients in ATB200, approved rhGAA, or
AT2221

6. Female subject is pregnant or breast-feeding at screening

7. Subject requires the use of ventilation support for > 6 hours per day while awake

8. Subject has evidence of moderate to severe hypertrophic cardiomyopathy aligning with
classic IOPD

9. In the opinion of the investigator, the parent or legally authorized representative is
unlikely or unable to comply with the study requirements

10. Subject has any prior history of illness or condition known to affect motor function,
such as, but not limited to, Guillain-Barre syndrome, cerebral palsy, etc

11. Subject who is diagnosed with Pompe disease via newborn screening and is asymptomatic
(ie, showing no signs and symptoms of Pompe disease (Cohort 2 Only)

Study design
Purpose of the study
Treatment
Allocation to intervention
N/A
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?



Intervention assignment
Single group
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Recruiting
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
13/02/2020
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
1/06/2026
Actual
Sample size
Target
22
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
SA
Recruitment hospital [1] 0 0
Women's and Children's Hospital - North Adelaide
Recruitment postcode(s) [1] 0 0
5006 - North Adelaide
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Arizona
Country [2] 0 0
United States of America
State/province [2] 0 0
Arkansas
Country [3] 0 0
United States of America
State/province [3] 0 0
California
Country [4] 0 0
United States of America
State/province [4] 0 0
Florida
Country [5] 0 0
United States of America
State/province [5] 0 0
Georgia
Country [6] 0 0
United States of America
State/province [6] 0 0
Michigan
Country [7] 0 0
United States of America
State/province [7] 0 0
Minnesota
Country [8] 0 0
United States of America
State/province [8] 0 0
Missouri
Country [9] 0 0
United States of America
State/province [9] 0 0
North Carolina
Country [10] 0 0
United States of America
State/province [10] 0 0
Virginia
Country [11] 0 0
Canada
State/province [11] 0 0
Alberta
Country [12] 0 0
Japan
State/province [12] 0 0
Izumi-Shi
Country [13] 0 0
Japan
State/province [13] 0 0
Gunma
Country [14] 0 0
Japan
State/province [14] 0 0
Miyagi
Country [15] 0 0
Japan
State/province [15] 0 0
Tokyo
Country [16] 0 0
Taiwan
State/province [16] 0 0
Taipei

Funding & Sponsors
Primary sponsor type
Commercial sector/Industry
Name
Amicus Therapeutics
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
This is a Phase 3, open-label, multicenter study to evaluate the safety, PK, efficacy, PD,
and immunogenicity of Cipaglucosidase Alfa/Miglustat treatment in enzyme replacement therapy
(ERT)-experienced and ERT-naïve pediatric subjects with Pompe disease, aged 0 to < 18 years
Trial website
https://clinicaltrials.gov/ct2/show/NCT03911505
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
For Site
Address 0 0
Country 0 0
Phone 0 0
215-921-7600
Fax 0 0
Email 0 0
PompeSiteInfo@amicusrx.com
Contact person for scientific queries



Summary Results

For IPD and results data, please see https://clinicaltrials.gov/ct2/show/NCT03911505