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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT04755491




Registration number
NCT04755491
Ethics application status
Date submitted
11/02/2021
Date registered
16/02/2021
Date last updated
13/09/2022

Titles & IDs
Public title
Chloride Transfer During Continuous Renal Replacement Therapy in the Intensive Care Unit: a Prospective Observational Cohort Study
Scientific title
Chloride Transfer During Continuous Renal Replacement Therapy in the Intensive Care Unit: a Prospective Observational Cohort Study
Secondary ID [1] 0 0
69HCL20_1055
Universal Trial Number (UTN)
Trial acronym
CLODICUS
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Acute Kidney Injury 0 0
Condition category
Condition code

Intervention/exposure
Study type
Observational
Patient registry
Target follow-up duration
Target follow-up type
Description of intervention(s) / exposure
Chloride transfer by continuous veno-venous hemofiltration - Chloride transfer over 24h of continuous veno-venous hemofiltration in mechanically ventilated ICU patients presenting with stage III AKI according to Kidney Disease: Improving Global Outcome (KDIGO) classification. Chloride concentrations will be measured in the serum, the urine, and the effluent of included patients every 4 to 6h from inclusion to H24.

Comparator / control treatment
Control group

Outcomes

Eligibility
Key inclusion criteria
* Adult patients (age > 18 years) affiliated to a social security regimen.
* Presenting with stage III AKI according to Kidney Disease: Improving Global Outcome (KDIGO) classification28.
* Treated with continuous RRT (CVVH or CVVD or CVVHDF) for less than 24 hours, whatever the method used.
* Mechanically ventilated at the time of inclusion in the study.
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Patients on chronic hemodialysis / peritoneal dialysis.
* Patients on extracorporeal membrane oxygenation
* Patients on intermittent hemodialysis (acute or chronic)
* RRT initiated for a different reason than stage III AKI according to Kidney Disease: Improving Global Outcome (KDIGO) classification
* Withholding of life sustaining treatment concerning RRT, mechanical ventilation or cardiopulmonary resuscitation.
* Patients whose life expectancy is lower than 24 hours
* Patients under guardianship or another juridical protection
* Patient's or next of kin opposition to participate
* Patients previously included in the study

Study design
Purpose
Duration
Selection
Timing
Prospective
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)

Funding & Sponsors
Primary sponsor type
Other
Name
Hospices Civils de Lyon
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Laurent BITKER, MD, PhD
Address 0 0
Hospices Civils de Lyon
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

No information has been provided regarding IPD availability


What supporting documents are/will be available?

No Supporting Document Provided



Results publications and other study-related documents

No documents have been uploaded by study researchers.