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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT03975647




Registration number
NCT03975647
Ethics application status
Date submitted
4/06/2019
Date registered
5/06/2019
Date last updated
7/08/2025

Titles & IDs
Public title
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
Scientific title
Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Subjects With Unresectable Locally-advanced or Metastatic HER2+ Breast Cancer (HER2CLIMB-02)
Secondary ID [1] 0 0
C4251001
Secondary ID [2] 0 0
SGNTUC-016
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
HER2-positive Breast Cancer 0 0
Condition category
Condition code

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - tucatinib
Treatment: Drugs - placebo
Treatment: Drugs - T-DM1

Experimental: Tucatinib + T-DM1 - Tucatinib + T-DM1

Active comparator: Placebo + T-DM1 - Placebo + T-DM1


Treatment: Drugs: tucatinib
300mg given twice per day by mouth (orally)

Treatment: Drugs: placebo
Given twice per day orally

Treatment: Drugs: T-DM1
3.6 mg/kg given into the vein (IV; intravenously) every 21 days

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Progression-Free Survival (PFS) as Per Response Evaluation Criteria in Solid Tumors (RECIST) Version (v)1.1 Based on Investigator Assessment
Timepoint [1] 0 0
From the date of randomization to the date of PD or death from any cause or censoring date, whichever occurred first (maximum up to 43 months)
Secondary outcome [1] 0 0
Overall Survival (OS)
Timepoint [1] 0 0
Up to approximately 5 years
Secondary outcome [2] 0 0
Progression-Free Survival as Per RECIST v1.1 in Participants With Brain Metastases at Baseline Based on Investigator Assessment
Timepoint [2] 0 0
From the date of randomization to the date of PD or death from any cause or censoring date, whichever occurred first (maximum up to 45 months)
Secondary outcome [3] 0 0
Objective Response Rate (ORR) as Per RECIST v1.1 Based on Investigator Assessment
Timepoint [3] 0 0
From the date of first CR or PR until the date of the first documentation of PD or death, whichever occurred first (maximum up to 43 months)
Secondary outcome [4] 0 0
Overall Survival in Participants With Brain Metastases at Baseline
Timepoint [4] 0 0
Up to approximately 5 years
Secondary outcome [5] 0 0
Progression-Free Survival as Per RECIST v1.1 Determined by Blinded Independent Committee Review (BICR)
Timepoint [5] 0 0
From the date of randomization to the date of PD or death from any cause or censoring date, whichever occurred first (maximum up to 43 months)
Secondary outcome [6] 0 0
Progression-Free Survival in Participants With Brain Metastases at Baseline as Per RECIST v1.1 Determined by BICR
Timepoint [6] 0 0
From the date of randomization to the date of PD or death from any cause or censoring date, whichever occurred first (maximum up to 43 months)
Secondary outcome [7] 0 0
Objective Response Rate as Per RECIST v1.1 Determined by BICR
Timepoint [7] 0 0
From the date of randomization to the date of PD or death from any cause or censoring date, whichever occurred first (maximum up to 43 months)
Secondary outcome [8] 0 0
Duration of Response (DOR) as Per RECIST v1.1 Based on Investigator Assessment
Timepoint [8] 0 0
Up to approximately 5 years
Secondary outcome [9] 0 0
Duration of Response as Per RECIST v1.1 by BICR
Timepoint [9] 0 0
Up to approximately 5 years
Secondary outcome [10] 0 0
Clinical Benefit Rate (CBR) Per RECIST v1.1 Based on Investigator Assessment
Timepoint [10] 0 0
Up to approximately 5 years
Secondary outcome [11] 0 0
Clinical Benefit Rate as Per RECIST v1.1 by BICR
Timepoint [11] 0 0
Up to approximately 5 years
Secondary outcome [12] 0 0
Number of Participants With Treatment Emergent Adverse Events (AEs)
Timepoint [12] 0 0
From start of treatment up to 30 days after the last study treatment (approximately 43 months)

Eligibility
Key inclusion criteria
*

* Histologically confirmed HER2+ breast carcinoma as determined by a sponsor-designated central laboratory
* History of prior treatment with a taxane and trastuzumab in any setting, separately or in combination
* Have progression of unresectable locally advanced/metastatic breast cancer after last systemic therapy, or be intolerant of last systemic therapy
* Measurable or non-measurable disease assessable by RECIST v1.1
* ECOG performance status score of 0 or 1
* CNS Inclusion - Based on screening contrast brain magnetic resonance imaging (MRI), participants must have at least one of the following:

(a) No evidence of brain metastases

(b) Untreated brain metastases not needing immediate local therapy

(c) Previously treated brain metastases
1. Brain metastases previously treated with local therapy may either be stable since treatment or may have progressed since prior local CNS therapy, provided that there is no clinical indication for immediate re-treatment with local therapy
2. Participants treated with CNS local therapy for newly identified lesions or previously treated and progressing lesions may be eligible to enroll if all of the following criteria are met:

(i) Time since SRS is at least 7 days prior to first dose of study treatment, time since WBRT is at least 14 days prior to first dose, or time since surgical resection is at least 28 days.

(ii) Other sites of evaluable disease are present
3. Relevant records of any CNS treatment must be available to allow for classification of target and non-target lesions
*
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Prior treatment with tucatinib, afatinib, trastuzumab deruxtecan (DS-8201a), or any other investigational anti-HER2, anti-EGFR, or HER2 TKI agent. Prior treatment with lapatinib or neratinib within 12 months of starting study treatment (except in cases where they were given for =21 days and was discontinued for reasons other than disease progression or severe toxicity). Prior treatment with pyrotinib for recurrent of mBC (except in cases where pyrotinib was given for =21 days and was discontinued for reasons other than disease progression or severe toxicity).
* CNS Exclusion - Based on screening contrast brain magnetic resonance imaging (MRI), participants must not have any of the following:

1. Any untreated brain lesions >2 cm in size
2. Ongoing use of corticosteroids for control of symptoms of brain metastases at a total daily dose of >2 mg of dexamethasone (or equivalent).
3. Any brain lesion thought to require immediate local therapy
4. Known or concurrent leptomeningeal disease as documented by the investigator
5. Poorly controlled generalized or complex partial seizures

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Active, not recruiting
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
NSW,VIC,WA
Recruitment hospital [1] 0 0
Patricia Ritchie Centre for Cancer Care and Research Mater Hospital Sydney - North Sydney
Recruitment hospital [2] 0 0
The Crown Princess Mary Cancer Centre, Westmead Hospital - Westmead
Recruitment hospital [3] 0 0
Austin Health - Heidelberg
Recruitment hospital [4] 0 0
Peter MacCallum Cancer Centre - Melbourne
Recruitment hospital [5] 0 0
The Royal Melbourne Hospital - Parkville
Recruitment hospital [6] 0 0
Epic Pharmacy Hollywood - Nedlands
Recruitment hospital [7] 0 0
Hollywood Private Hospital - Nedlands
Recruitment hospital [8] 0 0
Starcevich Day Clinic, Hollywood Private Hospital - Nedlands
Recruitment hospital [9] 0 0
Breast Cancer Research Centre - WA - Nedlands
Recruitment postcode(s) [1] 0 0
2060 - North Sydney
Recruitment postcode(s) [2] 0 0
2145 - Westmead
Recruitment postcode(s) [3] 0 0
3084 - Heidelberg
Recruitment postcode(s) [4] 0 0
3000 - Melbourne
Recruitment postcode(s) [5] 0 0
3050 - Parkville
Recruitment postcode(s) [6] 0 0
6009 - Nedlands
Recruitment outside Australia
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United States of America
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Alabama
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Arizona
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California
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District of Columbia
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Georgia
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Hawaii
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Illinois
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Nebraska
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Innsbruck
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Hokkaido
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Hyogo
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Singapore
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Spain
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Santa CRUZ DE Tenerife
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Córdoba
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Taipei
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Cornwall
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Birmingham
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London
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Manchester
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United Kingdom
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Sutton

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
Seagen, a wholly owned subsidiary of Pfizer
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Pfizer CT.gov Call Center
Address 0 0
Pfizer
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Seagen Trial Information Support
Address 0 0
Country 0 0
Phone 0 0
866-333-7436
Fax 0 0
Email 0 0
Contact person for scientific queries

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
What data in particular will be shared?
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.
When will data be available (start and end dates)?
Available to whom?
Available for what types of analyses?
How or where can data be obtained?
IPD available at link: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests


What supporting documents are/will be available?

Results publications and other study-related documents

No documents have been uploaded by study researchers.