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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT02516553
Registration number
NCT02516553
Ethics application status
Date submitted
27/07/2015
Date registered
6/08/2015
Date last updated
15/04/2024
Titles & IDs
Public title
BI 894999 First in Human Dose Finding Study in Advanced Malignancies
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Scientific title
An Open Label, Phase Ia/Ib Dose Finding Study With BI 894999 Orally Administered Once a Day in Patients With Advanced Malignancies, With Repeated Administration in Patients With Clinical Benefit
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Secondary ID [1]
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2015-001111-12
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Secondary ID [2]
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1367.1
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Universal Trial Number (UTN)
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Trial acronym
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Neoplasms
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NUT Carcinoma
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Condition category
Condition code
Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - BI 894999
Experimental: Phase Ia - Schedule A: 0.2 mg BI 894999 - Once daily continuous oral intake in 3-week cycles.
Experimental: Phase Ia - Schedule A: 0.5 mg BI 894999 - Once daily continuous oral intake in 3-week cycles.
Experimental: Phase Ia - Schedule A: 1 mg BI 894999 - Once daily continuous oral intake in 3-week cycles.
Experimental: Phase Ia - Schedule A: 1.5 mg BI 894999 - Once daily continuous oral intake in 3-week cycles.
Experimental: Phase Ia - Schedule A: 2 mg BI 894999 - Once daily continuous oral intake in 3-week cycles.
Experimental: Phase Ia - Schedule A: 5 mg BI 894999 - Once daily continuous oral intake in 3-week cycles.
Experimental: Phase Ia - Schedule B: 1.5 mg BI 894999 - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ia - Schedule B: 2 mg BI 894999 - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ia - Schedule B: 2.5 mg BI 894999 - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ia - Schedule C: 5/2.5 mg BI 894999 - Once daily loading dose on Day 1 followed by six days daily intake of maintenance dose, followed by one week off, repeated every two weeks in cycles of 28 days.
Experimental: Phase Ia - Schedule C: 6/3 mg BI 894999 - Once daily loading dose on Day 1 followed by six days daily intake of maintenance dose, followed by one week off, repeated every two weeks in cycles of 28 days.
Experimental: Phase Ia - Schedule C: 7/3.5 mg BI 894999 - Once daily loading dose on Day 1 followed by six days daily intake of maintenance dose, followed by one week off, repeated every two weeks in cycles of 28 days.
Experimental: Phase Ia - Schedule B: 1.5 mg BI 894999 (DLBCL patients) - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ia - Schedule B: 2 mg BI 894999 (DLBCL patients) - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ia - Schedule B: 2.5 mg BI 894999 (DLBCL patients) - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ia - Schedule C: 4/2 mg BI 894999 (DLBCL patients) - Once daily loading dose on Day 1 followed by six days daily intake of maintenance dose, followed by one week off, repeated every two weeks in cycles of 28 days.
Experimental: Phase Ia - Schedule C: BI 894999 5/2.5 mg (DLBCL patients) - Once daily loading dose on Day 1 followed by six days daily intake of maintenance dose, followed by one week off, repeated every two weeks in cycles of 28 days.
Experimental: Phase Ib - Schedule B: 2 or 2.5 mg BI 894999 (SCLC patients) - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ib - Schedule B: 2.5 mg BI 894999 (CRC patients) - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ib - Schedule B: 2 or 2.5 mg BI 894999 (mCRPC patients) - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ib - Schedule B: 2.5 mg BI 894999 (NC patients) - Once daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles.
Experimental: Phase Ib - Schedule C: 6/3 or 7/3.5 mg BI 894999 (NC patients) - Once daily loading dose on Day 1 followed by six days daily intake of maintenance dose, followed by one week off, repeated every two weeks in cycles of 28 days.
Treatment: Drugs: BI 894999
film-coated tablets
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Intervention code [1]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Phase Ia: Number of Patients With DLTs Observed in the First Cycle
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Assessment method [1]
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Number of patients with Dose Limiting Toxicities (DLTs) observed in the first treatment cycle of Phase Ia is reported. The following drug related adverse events (AEs) qualified as DLT: * any Common Terminology Criteria for Adverse Events (CTCAE) grade =3 non haematological toxicity considered related to trial medication with the following exceptions: * inadequately treated nausea, vomiting or diarrhoea. For fatigue, if present at baseline, there had to be an increase of =2 grades * electrolytes abnormalities that were corrected within 72 hours with treatment * any haematologic AE related to the trial medication defined as follows: * CTCAE grade =4 neutropenia lasting = 7 days and/or complicated by infection, or * CTCAE grade =4 thrombocytopenia, or * CTCAE grade= 3 thrombocytopenia coupled with grade = 2 of bleeding, or * febrile neutropenia CTCAE grade 3 or higher. * any other drug-related AE preventing the patient from taking his treatment according to the given schedule.
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Timepoint [1]
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First treatment cycle (the first 21 days for Schedules A and B, the first 28 days for Schedule C).
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Primary outcome [2]
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Phase Ib: Number of Patients With DLTs Observed During the On-treatment Period
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Assessment method [2]
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Number of patients with Dose Limiting Toxicities (DLTs) observed during the on-treatment period of Phase Ib is reported. The following drug related adverse events (AEs) qualified as DLT: * any Common Terminology Criteria for Adverse Events (CTCAE) grade =3 non haematological toxicity considered related to trial medication with the following exceptions: * inadequately treated nausea, vomiting or diarrhoea. For fatigue, if present at baseline, there had to be an increase of =2 grades * electrolytes abnormalities that were corrected within 72 hours with treatment * any haematologic AE related to the trial medication defined as follows: * CTCAE grade =4 neutropenia lasting = 7 days and/or complicated by infection, or * CTCAE grade =4 thrombocytopenia, or * CTCAE grade= 3 thrombocytopenia coupled with grade = 2 of bleeding, or * febrile neutropenia CTCAE grade 3 or higher. * any other drug-related AE preventing the patient from taking his treatment according to the given schedule.
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Timepoint [2]
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Date of the first administration of study treatment until date of the last administration of study treatment + 30 days residual effect period, up to 883 days.
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Secondary outcome [1]
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Phase Ia: Number of Patients With DLTs Observed During the On-treatment Period
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Assessment method [1]
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Number of patients with DLTs observed during the on-treatment period of Phase Ia is reported. The following drug related adverse events (AEs) qualified as DLT: * any Common Terminology Criteria for Adverse Events (CTCAE) grade =3 non haematological toxicity considered related to trial medication with the following exceptions: * inadequately treated nausea, vomiting or diarrhoea. For fatigue, if present at baseline, there had to be an increase of =2 grades * electrolytes abnormalities that were corrected within 72 hours with treatment * any haematologic AE related to the trial medication defined as follows: * CTCAE grade =4 neutropenia lasting = 7 days and/or complicated by infection, or * CTCAE grade =4 thrombocytopenia, or * CTCAE grade= 3 thrombocytopenia coupled with grade = 2 of bleeding, or * febrile neutropenia CTCAE grade 3 or higher. * any other drug-related AE preventing the patient from taking his treatment according to the given schedule.
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Timepoint [1]
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Date of the first administration of study treatment until date of the last administration of study treatment + 30 days residual effect period, up to 463 days.
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Secondary outcome [2]
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Phase Ia and Phase Ib: Area Under the Concentration-time Curve of BI 894999 in Plasma Over the Time Interval From 0 to 24 Hours After Administration of the First Dose (AUC0-24)
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Assessment method [2]
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Area under the concentration-time curve of BI 894999 in plasma over the time interval from 0 to 24 hours after administration of the first dose (AUC0-24) for Phase Ia and Phase Ib is reported.
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Timepoint [2]
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5 minutes (min) before and at 30 min, 1 hour (h), 2h, 3h, 4h, 6h, 8h and 23h55min after administration of first BI 894999 dose on Day 1 of Cycle 1.
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Secondary outcome [3]
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Phase Ia and Phase Ib: Maximum Measured Concentration of BI 894999 in Plasma After the First Dose (Cmax)
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Assessment method [3]
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Maximum measured concentration of BI 894999 in plasma after the first dose (Cmax) for Phase 1a and Phase 1b is reported.
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Timepoint [3]
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5 minutes (min) before and at 30 min, 1 hour (h), 2h, 3h, 4h, 6h, 8h and 23h55min after administration of first BI 894999 dose on Day 1 of Cycle 1.
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Secondary outcome [4]
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Phase Ia and Phase Ib: Area Under the Concentration-time Curve of BI 894999 in Plasma at Steady State Over a Uniform Dosing Interval t (AUCt, ss)
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Assessment method [4]
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Area under the concentration-time curve of BI 894999 in plasma at steady state over a uniform dosing interval t (AUCt, ss) for Phase Ia and Ib is reported. The dosing interval is 24 hours (h) for all dose groups.
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Timepoint [4]
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5 minutes (min) before and at 30 min, 1 hour (h), 2h, 3h, 4h, 6h, 8h, and at 23h55min (Schedule A) or 24h (Schedule B & C) following administration on day 14 (Schedule A & B) or day 21 (Schedule C).
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Secondary outcome [5]
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Phase Ia and Phase Ib: Maximum Measured Concentration of BI 894999 in Plasma at Steady State Over a Uniform Dosing Interval t (Cmax, ss)
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Assessment method [5]
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Maximum measured concentration of BI 894999 in plasma at steady state over a uniform dosing interval t (Cmax, ss) for Phase Ia and Phase Ib is reported. The dosing interval is 24 hours (h) for all dose groups.
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Timepoint [5]
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5 minutes (min) before and at 30 min, 1 hour (h), 2h, 3h, 4h, 6h, 8h, and at 23h55min (Schedule A) or 24h (Schedule B & C) following administration on day 14 (Schedule A & B) or day 21 (Schedule C).
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Secondary outcome [6]
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Phase Ia and Phase Ib: Objective Response (OR)
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Assessment method [6]
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OR was defined as best overall response (BOR) of complete response (CR) or partial response (PR) with tumour assessment during treatment period for each schedule. For DLBCL patients, a minor response according to Response Evaluation Criteria In Lymphoma 2017 (RECIL 2017) was not part of an objective response. BOR was determined from first treatment administration until the earliest of disease progression, death or last evaluable tumour assessment before start of subsequent anticancer therapy, loss to follow-up or withdrawal of consent, according to the following criteria depending on the type of cancer: * solid tumour patients and mCRPC patients with measurable disease: CT and/ or MRI according to RECIST v1.1, every 2 cycles; * mCRPC patients without measurable disease: bone scan and PSA level according to Prostate Cancer Clinical Trials Working Group 3, every 4 cycles; * DLBCL patients:FDG-PET/CT scans according to RECIL 2017; every 2 cycles.
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Timepoint [6]
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Up to 15 months for Phase 1a and up to 28 months for Phase Ib.
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Secondary outcome [7]
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Phase Ib: Progression-free Survival or (PFS) or Radiological PFS for mCRPC Patients With Non-measurable Disease by RECIST v1.1
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Assessment method [7]
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Progression-free survival (PFS) was defined as the time from date of start of BI 894999 to the date of objective disease progression ((PD) defined as 20% increase in the sum of the longest diameter of target lesions) or death, whichever is earlier for SCLC patients, CRC patients, mCRPC patients with measurable disease by Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) and NC patients, with tumour assessment every 2 cycles according to RECIST v1.1 during treatment period or Radiological PFS with tumour assessment by bone scan every 4 cycles for mCRPC patients with non-measurable disease by RECIST v1.1. For patients with 'event' as an outcome for PFS: \- PFS \[days\] = date of outcome - date of first treatment administration + 1. For patients with 'censored' as an outcome for PFS: \- PFS (censored) \[days\] = date of outcome - date of first treatment administration + 1. The Kaplan-Meier method was used to calculate the estimates.
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Timepoint [7]
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Up to 28 months.
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Secondary outcome [8]
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Phase Ib: Best Overall Response
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Assessment method [8]
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Best overall response (BOR) was determined from first treatment administration until the earliest of disease progression, death or last evaluable tumour assessment before start of subsequent anticancer therapy, loss to follow-up or withdrawal of consent, according to the following criteria depending on the type of cancer: * solid tumour patients and mCRPC patients with measurable disease: Computerized tomography (CT) and/ or magnetic resonance imaging (MRI) according to RECIST v1.1, every 2 cycles; * mCRPC patients without measurable disease: bone scan and PSA level according to Prostate Cancer Clinical Trials Working Group 3, every 4 cycles.
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Timepoint [8]
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Imaging and assessment performed every 2 cycles (solid tumours patients) or 4 cycles (mCRPC patients) for the entire treatment period, up to 28 months.
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Secondary outcome [9]
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Phase Ib: Overall Survival
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Assessment method [9]
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Overall survival (OS) was defined as the time from first administration of BI 894999 until death from any cause in patients with NUT carcinoma. For patients with 'event' as an outcome for OS: \- OS \[days\] = date of outcome - date of first treatment administration + 1. For patients with 'censored' as an outcome for OS: \- OS (censored) \[days\] = date of outcome - date of first treatment administration + 1. The Kaplan-Meier method was used to calculate the estimates.
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Timepoint [9]
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Up to 28 months.
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Secondary outcome [10]
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Phase Ib: Prostate Specific Antigen (PSA) Response in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
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Assessment method [10]
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PSA response was defined as a decline in PSA value =50% from baseline (which is confirmed by a second value 3 to 4 weeks apart).
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Timepoint [10]
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Up to 93 days.
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Eligibility
Key inclusion criteria
Inclusion criteria:
For all patients
* Age 18 years or older at the time of signature of the informed consent.
* Life expectancy of at least 12 weeks after the start of the treatment according to the investigator's judgement
* Male or female patients. Women of childbearing potential* must be ready and able to use highly effective methods of birth control per ICH M3(R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information. For women of childbearing potential using a contraceptive pill, an additional barrier method is necessary due to the potential CYP3A4 inducing effect of BI894999. Male patients having a partner of childbearing potential must use condoms and ensure their partner is using a highly effective method of birth control as described above, during the trial and for at least three months after the end of the trial * Any female who has experienced menarche and does not meet the criteria for "women not of childbearing potential" as described below.
Women not of childbearing potential are defined as: women who are postmenopausal (12 months with no menses without an alternative medical cause) or who are permanently sterilized (e.g., tubal occlusion, hysterectomy, bilateral oophorectomy or bilateral salpingectomy).
- Written informed consent consistent with ICH-GCP and local legislation
For patients with solid tumours
* Patients with a histologically or cytologically confirmed diagnosis of an advanced unresectable and/or metastatic, malignant solid tumour, who have failed conventional treatment or for whom no therapy of proven efficacy exists, or who are not amenable to standard therapies
* Age = legal age to be adult for the given country at the time of signature of the informed consent. For NC patients, age 15 years or older at the time of signature of the informed consent ( in Germany and South Korea, only legally adult patients may be included
* Eastern Cooperative Oncology Group (ECOG, R01-0787) performance score 0 or 1 at the time of screening. A score of 2 is allowed for NUT carcinoma patients
* Recovery of therapy-related toxicities from previous chemotherapy, tyrosine kinase inhibitors, hormone therapy, immunotherapy, antibodies, vaccine therapy, or radiotherapy to CTCAE = grade 1 (with the exception of alopecia, peripheral sensory neuropathy grade 2)
* Life expectancy of at least 12 weeks after the start of the treatment according to the investigator's judgement
* Male or female patients. Women of childbearing potential* must be ready and able to use highly effective methods of birth control per ICH M3(R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information. For women of childbearing potential using a contraceptive pill, an additional barrier method is necessary due to the potential CYP3A4 inducing effect of BI894999. Male patients having a partner of childbearing potential must use condoms and ensure their partner is using a highly effective method of birth control as described above, during the trial and for at least three months after the end of the trial treatment
* Written informed consent consistent with ICH-GCP and local legislation. For adolescent NC patients aged 15 years to < legal adult age, written assent of the patient and written informed consent of the parents (both or one according to national regulation) or legal guardian of the adolescent
* Written informed consent for tumour biopsies in the escalation phase Ia
* Optional for those patients until extension of the MTD cohort,
* Optional for the patients in the extension of MTD cohort at the same time points as described below for the expansion phase. For these patients in the extension of the MTD cohort, if they have an accessible lesion for biopsy, they will be offered optional consent for tumour biopsies
* In addition, all patients included in the expansion Phase Ib must:
* Have been diagnosed with one of the four types of tumours selected:
* small cell lung cancer (SCLC)
* metastatic castrate resistant prostate cancer (mCRPC)
* colorectal cancer (CRC)
* NUT carcinoma (NC) (for which the "midline" origin is not a prerequisite)
* Have failed conventional treatments or who are not amenable to standard therapies (per criterion 1) that specifically include for:
* SCLC: a platinum-based therapy (previous treatment with topotecan is not mandatory)
* mCRPC: a hormonal agent (abiraterone, enzalutamide, or apalutamide) and a taxane (docetaxel or cabazitaxel)
* CRC: fluoropyrimidine, oxaliplatin and irinotecan, bevacizumab for patients eligible to this treatment and an anti-epidermal growth factor receptor (EGFR) in RAS (Rat Sarcoma Virus) wild type metastatic CRC.
* Have measurable disease (radiated lesions and lesions used for biopsy do not qualify as target lesions), according to RECIST 1.1 (R09-0262) (for NC patients only nonmeasurable disease is acceptable); or according to PCWG3 (R17-3377) for the mCRPC cohort (see point 5 of inclusion criteria below, specific to mCRPC patients)
* Have progressive disease within the last 6 months, according to RECIST 1.1 (R09-0262) or according to PCWG3 (R17-3377) for the mCRPC cohort (see point 5 of inclusion criteria below, specific to mCRPC patients). NC patients do not need to show progression per RECIST 1.1 (for example, if newly diagnosed).
* Have a tumour lesion accessible for biopsies (pre- and at steady state under treatment in Cycle 1, ideally from the same anatomic lesion) (except for mCRPC patients having only bone metastases or for patients with therapeutic INR because of treatment with a vitamin K antagonist or a novel oral anticoagulant. Biopsies are optional for NC patients
* Give written informed consent for two tumour biopsies, one at screening and one after start of treatment, between Day 8 and Day 11 of Cycle 1 (or between day 3 and day 8 if the day of biopsy in Cycle 1 needs to be moved as explained in Section 3.1) (when applicable)
* In addition, all patients in the mCRPC expansion cohort of Phase Ib must have:
* Histologically or cytologically confirmed adenocarcinoma of the prostate
* Radiographic evidence of metastatic prostate cancer (stage M1 or D2). Distant metastases evaluable by bone scan, CT scan, or MRI within 28 days before the start of study treatment.
* PSA = 5 ng/mL (if no measurable disease by RECIST 1.1)
* Prior surgical or chemical castration with a serum testosterone of <50 ng/dL (< 1.7 nmol/L) by luteinizing hormone releasing level hormone (LHRH) agonist or antagonist, or by abiraterone or by enzalutamide or apalutamide. If the actual method of castration is LHRH agonist or antagonist, the patient must be willing to continue the use of LHRH agonist or antagonist during protocol treatment.
* Progressive disease defined as at least one of the following:
* Progressive measurable disease: using conventional solid tumour criteria RECIST 1.1
* Bone scan progression: at least two new lesions on bone scan plus a rising PSA as described in point c below
* Increasing PSA level: at least two consecutive rising PSA values over a reference value (PSA no.1) taken at least 1 week apart. A third PSA (PSA no. 3) is required to be > than PSA no. 2; if not, a fourth PSA (PSA no. 4) is required to be > to PSA no. 2
In patients with DLBCL
* Patients with histologically confirmed DLBCL who have failed 2 or more lines of systemic therapy including an anti-CD-20 therapy and an anthracycline or who are not amenable to standard therapies but have an indication for therapy as per investigator's judgement. Standard therapies may also include but are not limited to CAR-T cells therapy, depending on approved therapies in the country where the patient is treated
* ECOG Performance Status 0, 1 or 2 at the time of screening
* Measurable disease (radiated lesions do not qualify as target lesions) according to according to RECIL 2017 on the CT scan part of the FDG/PET-CT scan
* Recovery of therapy-related toxicities from previous anti-lymphoma therapy to CTCAE <= grade 1 (with the exception of alopecia, peripheral sensory neuropathy grade 2)
* written informed consent for tumour biopsies (optional)
* Further inclusion criteria apply
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
Exclusion criteria:
For all patients:
* Inability to swallow tablets
* Additional other serious illness, concomitant non-oncological disease (e.g. active infectious disease including an active infection with SARS-CoV-2 confirmed by a PCR test or had one in the prior 6 weeks or active hepatitis (Hep) B infection as defined by positive Hep B DNA test, active Hep C infection as defined by positive Hep C RNA test and human immunodeficiency virus (HIV) infection (positive result in established HIV diagnostic assay), or ongoing toxicity from prior therapies considered by the investigator to potentially compromise patient's safety in this trial
* Serum creatinine greater than 1.5 mg/dL (>132 µmol/L, SI unit equivalent)
* Women who are pregnant, nursing, or who plan to become pregnant while in the trial
* Treatment with other investigational drugs or participation in another clinical interventional trial within the past four weeks or within five times the half-life of the previous investigational drug, whichever is shorter, before start of therapy or concomitant with this trial
* Patients unable to comply with the protocol
* Patients who are actively abusing alcohol or drugs. Since no alcohol or drug testing is required per protocol, it is at the investigator's discretion to determine abuse.
For patients with solid tumours:
* Additional other serious illness , concomitant non-oncological disease (e.g. active infectious disease or known chronic Hepatitis B/Hepatitis C infection and HIV), or ongoing toxicity from prior therapies considered by the investigator to potentially compromise patient's safety in this trial
* History or presence of cardiovascular abnormalities deemed clinically relevant by the investigator such as uncontrolled hypertension, congestive heart failure NYHA classification of 3, unstable angina or poorly controlled arrhythmia. Myocardial infarction within 6 months prior to study entry.Left Ventricular Ejection Fraction (LVEF) less than 50% at baseline
* Clinical evidence of symptomatic progressive brain or leptomeningeal disease during the last 28 days before the start of treatment with BI 894999
* Absolute neutrophil count less than 1500/mm^3
* Platelet count less than 100 000/mm^3
* Bilirubin greater than 1.5 mg/dL (>26 µmol/L, SI unit equivalent) (except known Gilbert's syndrome, accepted up to 2 mg/dL or up to 34.2 µmol/L in this case)
* Aspartate amino transferase (AST) and/or alanine amino transferase (ALT) greater than 2.5 times the upper limit of normal (if related to liver metastases, greater than five times the upper limit of normal)
* Treatment with other investigational drugs or participation in another clinical interventional trial within the past four weeks (past two weeks for NC patients) or within five times the half-life of the previous investigational drug, whichever is the shorter, before start of therapy or concomitant with this trial
* Systemic anti-cancer therapy within four weeks (past two weeks for NC patients) or five times the half-life of the drug, whichever is shorter. Radiotherapy given for curative intent or other than palliative radiotherapy within the past four weeks before start of therapy or concomitantly with this trial. This These restrictions does not apply to LHRH agonists or antagonists, steroids (given at a stable dose in the last four weeks) used for palliative intent, bisphosphonates, and denosumab and to palliative radiotherapy (no wash out required)
For patients with DLBCL:
* Patient is eligible for curative salvage high dose therapy followed by stem cell transplant.
* Primary central nervous system (CNS) lymphoma or known CNS involvement
* Prior allogeneic bone marrow or stem cell transplant
* High-dose therapy with stem cell support <3 months prior to visit 1
* AST or ALT >2.5 x upper limit of normal (CTCAE grade 2 or higher)
* Total bilirubin >1.5 x upper limit of normal (CTCAE grade 2 or higher)
* Absolute neutrophil count <1.0 x 10^9/L(without growth factor support)
* Platelets <100 x 10^9/L (without transfusions)
* Significant concurrent medical disease or condition which according to the investigator's judgement would either compromise patient safety or interfere with the evaluation of the safety of the test drug, e.g. symptomatic congestive heart failure, unstable angina pectoris, myocardial infarction within 6 months prior to study entry, cardiac arrhythmia requiring therapy with the exception of extra systoles or minor conduction abnormalities
* Chronic or ongoing infection requiring treatment at the time of enrolment or within the previous two weeks, e.g. active infectious disease or known Hepatitis B/Hepatitis C infection, HIV
* Systemic anti-DLBCL therapy within the past two weeks or five times the half-life of the drug, whichever is shorter (palliative radiotherapy and agents used for palliative reasons for example steroids and bisphosphonates, are allowed)
* Further exclusion criteria apply
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Non-randomised trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Open (masking not used)
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Who is / are masked / blinded?
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Intervention assignment
Other
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Other design features
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Phase
Phase 1
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
8/07/2015
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
23/11/2021
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Sample size
Target
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Accrual to date
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Final
174
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Recruitment in Australia
Recruitment state(s)
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Recruitment outside Australia
Country [1]
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0
United States of America
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State/province [1]
0
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Massachusetts
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Country [2]
0
0
United States of America
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State/province [2]
0
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New York
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Country [3]
0
0
United States of America
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State/province [3]
0
0
Ohio
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Country [4]
0
0
United States of America
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State/province [4]
0
0
Texas
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Country [5]
0
0
Belgium
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State/province [5]
0
0
Anderlecht
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Country [6]
0
0
Belgium
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State/province [6]
0
0
Brussels
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Country [7]
0
0
Belgium
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State/province [7]
0
0
Ghent
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Country [8]
0
0
Belgium
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State/province [8]
0
0
Leuven
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France
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Marseille
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France
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Nantes
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France
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Paris
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France
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Villejuif
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Germany
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Tübingen
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South Korea
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Seoul
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Spain
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Barcelona
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Spain
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Madrid
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
Boehringer Ingelheim
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Address
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Ethics approval
Ethics application status
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Summary
Brief summary
This study is open to adults with different types of advanced cancer (solid tumours). The study is also open to patients with diffuse large B-cell lymphoma in whom previous treatment was not successful. In some countries, adolescents who are at least 15 years old and who are diagnosed with NUT carcinoma can also participate. No standard treatment exists for this rare and aggressive form of cancer. The purpose of this study is to find out the highest dose of BI 894999 that people can tolerate. BI 894999 is tested for the first time in humans. Participants take tablets once daily. The study also tests whether participants can tolerate BI 894999 better when taken continuously or with breaks in between. Participants can stay in the study as long as they benefit from the treatment and can tolerate it. The doctors also regularly check the general health of the participants.
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Trial website
https://clinicaltrials.gov/study/NCT02516553
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Trial related presentations / publications
Schoffski P, Machiels JP, Rottey S, Sadrolhefazi B, Musa H, Marzin K, Awada A. Phase Ia dose-escalation trial with the BET protein inhibitor BI 894999 in patients with advanced or metastatic solid tumours. Eur J Cancer. 2023 Sep;191:112987. doi: 10.1016/j.ejca.2023.112987. Epub 2023 Jul 11.
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Public notes
This record is viewable in the ANZCTR as it had previously listed Australia and/or New Zealand as a recruitment site, however these sites have since been removed
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Contacts
Principal investigator
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Boehringer Ingelheim
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Boehringer Ingelheim
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Contact person for scientific queries
Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
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What data in particular will be shared?
After the study is completed and the primary manuscript is accepted for publishing, researchers can use this following link https://www.mystudywindow.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".
Also, Researchers can use the following link https://www.mystudywindow.com/msw/datasharing to find information in order to request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.
The data shared are the raw clinical study data sets.
Supporting document/s available: Study protocol, Statistical analysis plan (SAP), Clinical study report (CSR)
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When will data be available (start and end dates)?
After all regulatory activities are completed in the US and EU for the product and indication, and after the primary manuscript has been accepted for publication.
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Available to whom?
For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by both the independent review panel and the sponsor, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a 'Data Sharing Agreement'.
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Available for what types of analyses?
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How or where can data be obtained?
IPD available at link: https://www.mystudywindow.com/msw/datasharing
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What supporting documents are/will be available?
No Supporting Document Provided
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Other Details
Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/53/NCT02516553/Prot_000.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/53/NCT02516553/SAP_001.pdf
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results are available at
https://clinicaltrials.gov/study/NCT02516553
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