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Trial details imported from

For full trial details, please see the original record at

Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
Cardiovascular Longitudinal Evaluation & Assessment of Risk (CLEAR) Study
Scientific title
Cardiovascular Longitudinal Evaluation & Assessment of Risk Study
Secondary ID [1] 0 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Cardiovascular Disease 0 0
Condition category
Condition code

Study type
Patient registry
Target follow-up duration
Target follow-up type
Description of intervention(s) / exposure
Comparator / control treatment
Control group

Primary outcome [1] 0 0
To assess risk factors for cardiovascular disease.
Timepoint [1] 0 0

Key inclusion criteria
- Patients above 18 years of age
Minimum age
18 Years
Maximum age
No limit
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- Risk assessment would constitute harm to patient

- Informed consent not obtainable

Study design
Statistical methods / analysis

Recruitment status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
Box Hill Hospital - Box Hill
Recruitment hospital [2] 0 0
Caulfield General Medical Centre - Caulfield
Recruitment hospital [3] 0 0
The Northern Hospital - Epping
Recruitment hospital [4] 0 0
Alfred Hospital - Melbourne
Recruitment postcode(s) [1] 0 0
- Box Hill
Recruitment postcode(s) [2] 0 0
- Caulfield
Recruitment postcode(s) [3] 0 0
- Epping
Recruitment postcode(s) [4] 0 0
3004 - Melbourne

Funding & Sponsors
Primary sponsor type
Monash University

Ethics approval
Ethics application status

Brief summary
The burden of cardiovascular disease (CVD) is considerable, despite many advances in
diagnosis, clinical management and drug therapy. The World Health Organization estimates 30%
of global deaths are attributable to CVD and whilst mortality rates in developed countries
are falling, it remains the largest single cause of death (WHO, 2007). Nineteen out of every
100 deaths in Australia are attributed to CVD, with an annual cost of $1.47 billion (AIHW,

Assessing the risk of future cardiovascular events is traditionally based on a number of
'risk-factors' determined by observational clinical studies such as the Framingham cohort.
Recent evidence however invalidates their use in both the highest and lowest risk groups and
raises questions about applying such methods in changing risk-behaviour. A considerable
number of new risk markers have surfaced in recent years (including various biomarkers, pulse
wave velocity and measures of arterial function). Unfortunately their long-term predictive
capacity is largely unknown, particularly when compared with existing risk factors.

The aims of this study are to provide objective longitudinal data for a wide variety of risk
markers both in current use and in development. Participants of current on-going clinical
studies at will be approached to lengthen their observation period for the purposes of
determining long-term clinical outcomes.

Standard clinical observations and data obtained within the participant's enrolled studies
will be collated into an electronic database. All existing and future studies must have
individual approval from an appropriate ethics committee with signed consent. The baseline
studies and follow-up assessments of this cohort will be correlated with cardiovascular
events, hospitalizations and mortality. In addition, volunteers can be directed to
appropriate clinical studies in CVD, thereby enhancing recruitment, encouraging good quality
clinical studies and advancing knowledge of cardiovascular disease prevention.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 0 0
Dipak Kotecha, MBChB MRCP
Address 0 0
Monash University
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Chris Reid, BA DipEd MSc PhD
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Summary results
For IPD and results data, please see