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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Date data sharing statement initially provided
Type of registration
Prospectively registered

Titles & IDs
Public title
Ultrasound guided embryo transfer for women undergoing In Vitro Fertilisation (IVF) for infertility - is it helpful for the procedure to be guided by a trained ultrasonographer and does this lead to the embryo being correctly placed more often?
Scientific title
Effect of sonographer guided embryo transfer versus ultrasound assisted transfer for visualisation of the bubble during embryo transfer.
Secondary ID [1] 300062 0
Nil known
Universal Trial Number (UTN)
Trial acronym
The GET study (Guided Embryo Transfer)
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Infertility 315582 0
Condition category
Condition code
Reproductive Health and Childbirth 313868 313868 0 0
Fertility including in vitro fertilisation

Study type
Description of intervention(s) / exposure
Sonographer guided embryo transfer - the sonographer holds the abdominal ultrasound probe and guides the doctor to correctly position the embryo transfer catheter. Following embryo transfer the sonographer measures the distance of the bubble(fluid with embryo in it) from the fundal endometrium. This will potentially add on 1-2 minutes to the procedure which takes approximately 5 minutes. A picture with the bubble and measurement will be printed and the data will be entered by an independent research nurse.
Intervention code [1] 316329 0
Treatment: Other
Comparator / control treatment
Ultrasound assisted embryo transfer ( the patient holds the abdominal ultrasound probe during embryo transfer) Following embryo transfer the doctor measures the position of the bubble from the fundal endometrium and a photo is printed. This may add 1-2 minutes to the procedure. The data will be entered by an independent research nurse.
Control group

Primary outcome [1] 322424 0
Visualisation of the bubble via transabdominal ultrasound
Timepoint [1] 322424 0
Immediately following embryo transfer
Secondary outcome [1] 378449 0
Position of the bubble from the fundal endometrium - measured in mm via ultrasound and photo printed
Timepoint [1] 378449 0
Immediately following embryo transfer
Secondary outcome [2] 378450 0
Difficulty of embryo transfer - this is determined by use of extra instruments such as an obturator, tenaculum and is recorded in the embryology notes every time a doctor performs an embryo transfer
Timepoint [2] 378450 0
Immediately following embryo transfer

Key inclusion criteria
All women undergoing frozen embryo transfer
Minimum age
18 Years
Maximum age
38 Years
Can healthy volunteers participate?
Key exclusion criteria
Donor egg or donor embryo

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Sealed envelope
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Block randomisation - computer generated
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis
Intention to treat analysis with percentages and odds ratios

Recruitment status
Not yet recruiting
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 15457 0
Repromed Day Surgery - Dulwich
Recruitment postcode(s) [1] 28810 0
5065 - Dulwich

Funding & Sponsors
Funding source category [1] 304514 0
Commercial sector/Industry
Name [1] 304514 0
Address [1] 304514 0
180 Fullarton Rd
Dulwich SA 5065
Country [1] 304514 0
Primary sponsor type
Dr Juliette Koch
180 Fullarton Rd
Dulwich SA 5065
Secondary sponsor category [1] 304787 0
Name [1] 304787 0
Address [1] 304787 0
Country [1] 304787 0

Ethics approval
Ethics application status
Ethics committee name [1] 304945 0
Womens and Childrens Health Network HREC
Ethics committee address [1] 304945 0
Level 1 Samuel Way Building
72 King William Rd
North Adelaide SA 5006
Ethics committee country [1] 304945 0
Date submitted for ethics approval [1] 304945 0
Approval date [1] 304945 0
Ethics approval number [1] 304945 0

Brief summary
Embryo transfer is the final process in the highly technical treatment of IVF. It is performed via the cervix and the embryo is placed into the uterine cavity via a fine catheter. Studies demonstrate that pregnancy rates are better when embryo transfer is performed under ultrasound guidance. Studies have also looked at the position of the bubble(fluid containing the embryo) on ultrasound following embryo transfer, with a sweet spot at 15mm from the fundal endometrium.
Currently in most clinics ultrasound guidance is not performed by a person formally trained in pelvic ultrasound. The ultrasound probe is often positioned by the doctor and held by the patient whilst the doctor performs the transfer. The researchers hypothesize that performing the transfer with a trained sonographer will lead to a higher number of embryos being in the best position in the uterine cavity. We hypothesize that as compared to a patient holding the ultrasound probe, the sonographer is skilled at locating the endometrium, dynamically adjusting the probe and guiding the doctor to place the embryo in the ideal position.
This study will assess the distance of the bubble from the fundal endometrium immediately following embryo transfer.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 98722 0
Dr Juliette Koch
Address 98722 0
180 Fullarton Rd
Dulwich SA 5063
Country 98722 0
Phone 98722 0
Fax 98722 0
Email 98722 0
Contact person for public queries
Name 98723 0
Dr Juliette Koch
Address 98723 0
180 Fullarton Rd
Dulwich SA 5063
Country 98723 0
Phone 98723 0
Fax 98723 0
Email 98723 0
Contact person for scientific queries
Name 98724 0
Dr Juliette Koch
Address 98724 0
180 Fullarton Rd
Dulwich SA 5063
Country 98724 0
Phone 98724 0
Fax 98724 0
Email 98724 0

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No/undecided IPD sharing reason/comment
Burden and cost of sharing
Potential difficulty with maintaining privacy
What supporting documents are/will be available?
Study protocol
Informed consent form
Ethical approval
How or where can supporting documents be obtained?
Type [1] 6149 0
Study protocol
Citation [1] 6149 0
Link [1] 6149 0
Email [1] 6149 0
Other [1] 6149 0
Type [2] 6150 0
Informed consent form
Citation [2] 6150 0
Link [2] 6150 0
Email [2] 6150 0
Other [2] 6150 0
Type [3] 6151 0
Ethical approval
Citation [3] 6151 0
Link [3] 6151 0
Email [3] 6151 0
Other [3] 6151 0
Summary results
No Results